(1) Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study.
(2) "gamma"-type phages contain DNA molecules of uniform size (about 52 kb) and of variable ends; their genome is able to promote highly efficient transduction (pug type) regardless of the origin of the right arm.
(3) Clinical and pathologic features of a sporadic, necrotizing meningoencephalitis affecting adolescent and mature pug dogs are described.
(4) Upstairs from the shop, full of quirky impulse buys such as Gemma Correll's Pugs not Drugs tote bags and Emily Warren's papier-mâché busts, there's studio and workshop space, with screen-printing equipment and sewing machines for regular workshops of up to six people.
(5) When PUG was tested for synergistic inhibition in the presence of caffeine, the Dixon plots of reciprocal velocity versus PUG concentration at different fixed caffeine concentrations provided intersecting lines with interaction constant (alpha) values of 0.95-1.38, indicating that the binding of one inhibitor is not significantly affected by the binding of the other.
(6) In solution, PUG was shown to be a potent inhibitor of phosphorylase b, directly competitive with alpha-D-glucopyranose 1-phosphate (glucose-1-P) (Ki = 0.40 mM) and noncompetitive with respect to glycogen and AMP.
(7) The properties of the second channel (channel 2), which is the more extensive channel, have been investigated with the potent beta-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane (PUG).
(8) Dogs of the Poodle, Pug, German Shepherd Dog, Cocker Spaniel, Bulldog, Schnauzer, Doberman Pinscher breeds, of mixed breeding, and of terrier breeds other than the 2 aforementioned were not found to have a higher prevalence, when compared with the general hospital population.
(9) Laryngeal obstruction occurs commonly in brachycephalic dogs (Bulldog, Boxer, Boston Terrier, Pug, Pikingese).
(10) A six-year old female pug had very severe dysponea.
(11) Lentiginosis profusa was diagnosed in 3 pedigree Pugs namely two unrelated parents and their female offspring.
(12) (1988) Biochemistry 27, 6733-6741] has shown that PUG binds in the catalytic site of phosphorylase b crystals with its gluconohydroximolactone moiety occupying a position similar to that observed for other glucosyl compounds and the N-phenylurethane side chain fitting into an adjacent cavity with little conformational change in the enzyme.
(13) However, in the presence of AMP, PUG exhibited complex kinetics, acting as a noncompetitive inhibitor with respect to glucose-1-P, while a twofold decrease of PUG binding to the enzyme-AMP-glycogen complex was observed.
(14) As he spoke an excited pug dog set itself the challenge of leaping backwards and forwards across his latest creation, Boyhood Line, a stripe of brilliant white limestone in the lush grass.
(15) The tale, drawn in the retro style of the golden age of adventure comics, portrays Johnson as a "dashing, pug-nosed chap, gallivanting around the world in search of danger and adventure".
(16) Christmas Pugs Snuggly pugs 3. iPad Art - Morgan Freeman Finger Painting Art with heart 5.
(17) The effect of the beta-glycosidase inhibitor D-gluconohydroximo-1,5-lactone-N-phenylurethane (PUG) on the kinetic and ultracentrifugation properties of glycogen phosphorylase has been studied.
(18) Ultracentrifugation experiments demonstrated that PUG does not cause any significant dissociation of phosphorylase alpha tetramer.
(19) Similarities among them were striking and consisted of varying combinations of the following features: moderate growth retardation; mild to severe mental retardation; facial elongation with frontal bossing; primary telecanthus and downward-slanting palpebral fissures; broad, flat, nose bridge and pug nose; pouting lower lip and blunt, square chin; umbilical eversion; deep sacral pit; and, in males, moderate to severe external genital anomalies ranging from mild hypospadias to genital ambiguity.
(20) Furthermore the dimerization of phosphorylase alpha by glucose is completely prevented in the presence of PUG.
Rugged
Definition:
(n.) Full of asperities on the surface; broken into sharp or irregular points, or otherwise uneven; not smooth; rough; as, a rugged mountain; a rugged road.
(n.) Not neat or regular; uneven.
(n.) Rough with bristles or hair; shaggy.
(n.) Harsh; hard; crabbed; austere; -- said of temper, character, and the like, or of persons.
(n.) Stormy; turbulent; tempestuous; rude.
(n.) Rough to the ear; harsh; grating; -- said of sound, style, and the like.
(n.) Sour; surly; frowning; wrinkled; -- said of looks, etc.
(n.) Violent; rude; boisterrous; -- said of conduct, manners, etc.
(n.) Vigorous; robust; hardy; -- said of health, physique, etc.
Example Sentences:
(1) The hosts had resisted through the early stages, emulating their rugged first-half displays against Manchester United and Arsenal here this season, and even mustered a flurry of half-chances just before the interval to offer a reminder they might glean greater reward thereafter.
(2) Steps wind down a rugged rock face to a bedroom, while light floods in from round skylights in the domed ceiling above.
(3) The Turner prize-winning artist has turned his sights on the survivalist and his exceptionally rugged version of masculinity, arguing that it isn’t fit for the 21st century.
(4) Many survivors use it to get the accommodations needed to stay in school, while others used it to hold their institutions accountable for sweeping sexual assault under the rug.” More than two dozen states are suing the Obama administration over its guidance on transgender students in an effort that is overwhelmingly led by Republican secretaries of state.
(5) As the president of Russia's Kalmykia republic from 1993 to 2010, Ilyumzhinov undoubtedly has close ties to the Kremlin, and a woven rug featuring Putin's face hangs in his office.
(6) Also, a wildfire in a rugged area near the Canadian border chased hundreds of people from their homes and burned 10 to 12 structures, and a blaze north-east of Colville scorched almost five square miles and forced evacuations at campgrounds in the area.
(7) Allergenic proteins were extracted from one silk batch that was imported to be used as filling material for bed mattresses and rugs.
(8) And reporting by the Observer reveals the extent to which al-Qaida has integrated itself with powerful tribes that control large swaths of Yemen's rugged east and parts of its south.
(9) FIVE MORE FRENCH COASTAL GEMS Marseille grotto Facebook Twitter Pinterest Photograph: Alamy A 40-minute walk from Marseille’s Luminy university campus, Calanque de Sugiton, the most picturesque of the city’s rugged, limestone coves has blue-green waters, twisted pine trees and a narrow island-rock to swim out to known as Le Torpilleur.
(10) Laminin and its E1-4 and E8 fragments are able to activate the ecto-5'-nucleotidase activity of both BCS-TC2 and Rugli cells.
(11) Pictures of the young Depardieu in a good light suggest a rugged, brooding, if not classically good-looking man with a squared chin and mop of blonde hair.
(12) In the presence of glucose oxidase and trien this polymer forms rugged, cross-linked, electroactive films on the surface of electrodes, thereby eliminating the requirement for a membrane for containing the enzyme and redox couple.
(13) The tone was set in the second minute when Ben Westwood, Warrington's notoriously rugged forward, left the Wigan stand-off Blake Green on the ground needing lengthy treatment.
(14) The simple design and rugged construction permit the incorporation of the apparatus into many manual or personal computer controlled oxygen consumption systems.
(15) Both offer lodges and campsites, but keep in mind that only a very small fraction of these remote and rugged parks are accessible by road.
(16) "When a similar report was released in 2009, the Administration largely swept it under the rug.
(17) La Posada has undergone a $12m renovation, transforming it into a magical place with handmade Mexican tin and tile mirrors, six-foot cast iron tubs, hand woven Zapotec rugs, and hand-painted furniture and tile murals.
(18) These assays have proven to be accurate, precise, reproducible, and rugged during clinical sample analyses.
(19) And cutting support now would take demand out of the economy, pull the rug from under the recovery, and delay our return to sustained growth.
(20) Chelsea had laboured at times without him in that first period, Begovic denying them reward from an urgent opening and Stoke rugged and organised until self-destructing with half-time in sight.