(v. t.) To cleanse, clear, or purify by separating and carrying off whatever is impure, heterogeneous, foreign, or superfluous.
(v. t.) To operate on as, or by means of, a cathartic medicine, or in a similar manner.
(v. t.) To clarify; to defecate, as liquors.
(v. t.) To clear of sediment, as a boiler, or of air, as a steam pipe, by driving off or permitting escape.
(v. t.) To clear from guilt, or from moral or ceremonial defilement; as, to purge one of guilt or crime.
(v. t.) To clear from accusation, or the charge of a crime or misdemeanor, as by oath or in ordeal.
(v. t.) To remove in cleansing; to deterge; to wash away; -- often followed by away.
(v. i.) To become pure, as by clarification.
(v. i.) To have or produce frequent evacuations from the intestines, as by means of a cathartic.
(v. t.) The act of purging.
(v. t.) That which purges; especially, a medicine that evacuates the intestines; a cathartic.
Example Sentences:
(1) Thus photosensitization using AISPc may be an effective method of purging marrow autografts in some cases of AML.
(2) Current investigations include the development of more effective cytoreductive regimens, use of recombinant hematopoietic growth factors, improvement of marrow purging techniques, and enhancement of cell-mediated anti-leukemic activity in patients receiving autologous marrow transplants.
(3) Direct detection of chromium in milk, using only argon as purge gas, was inferior.
(4) Indiana Indiana began to purge inactive voters in may 2014 by sending postcards to all registered voters.
(5) Sequential application of the two methods (immunorosette depletion with CD19 McAb followed by a complement lysis with CD9 and CD10 McAbs) led to superior results in causing a 4- to 5-log purging effect.
(6) Reduced caloric intake, a hallmark of both disorders, is manifested by self-induced starvation in anorexia and by binge eating and gastrointestinal purging in bulimia.
(7) Mafosfamide is presently used for the purging of bone marrow in autologous bone marrow transplantation in the treatment of acute leukemia.
(8) The two log difference in the surviving fraction of CFU-L and CFU-S after 120 min exposure to 42.5 degrees C suggests that hyperthermia ex vivo may be a suitable purging method for autologous bone marrow transplantation.
(9) There are already calls for large protests in Egypt this week demanding fair trials and retribution, as well as measures to purge former regime officials from political and economic life.
(10) Our data suggest that this new strategy shows potential for more effective ex vivo marrow purging in autologous marrow transplantation for acute lymphoblastic leukemia.
(11) In summary, laser light-induced photosensitization with MC540 has a selective cytotoxicity to leukemic cells; therefore, this procedure may be useful for purging neoplastic cells from autologous BM.
(12) Pretransplantation regimes were: total-body irradiation (TBI), 456; busulfan plus cyclophosphamide (BU-CY) 174; marrow purging with mafosfamide, 269 (corresponding to 26% of all patients in CR1 and 41% in CR2).
(13) Phase 1 studies of "in vivo purging" with a monovalent CD3 antibody (Clark et al., 1989), and also with a genetically engineered humanized IgG1 (CAMPATH-1H) (Hale et al., 1988b) suggest that these limitations can be overcome.
(14) Despite patient and disease heterogeneity, different sources of hemopoietic stem cells (allogeneic or autologous, bone marrow or blood), ex vivo purging of autografts, and different preparative regimens, some general recommendations can be made: (1) Allogeneic BMT should be reserved for patients under age 50, where transplant-related mortality can be expected not to exceed 30%; 40% will achieve CR with a 3-year relapse-free survival expectation of 70%, and (2) With autologous transplantation, low mortality under 10% and marked therapeutic benefit (greater than 30% CR, 80% overall survival at greater than 3 years) seem to be achievable mainly if performed when tumor bulk is low and standard doses of therapy are still effective.
(15) The transfusion purging leukocytes may diminish the occasions of alloimmunization.
(16) The Brotherhood's Libyan incarnation won only 10% of the vote in last year's congressional elections, but gained support with its campaign to mandate wholesale purges of Gaddafi-era officials.
(17) We feel that this system will prove valuable for monitoring ex vivo tumor removal in future clinical studies and should be considered for use in other purging trials.
(18) The quantitative determination of the efficacy of these purging methods is generally difficult.
(19) The government began aggressively purging the heads of cultural and academic institutions (a notable number of them Jewish and liberal intellectuals suspected of a “foreign” mindset) and installing in their stead true believers in the Magyar way.
(20) The result of our study in patients in second and third remission using in vitro purging of bone marrow with monoclonal antibodies PM-81 and AML2-23 are encouraging, as are the studies of purging with 4-HC.
Purre
Definition:
(n.) The dunlin.
Example Sentences:
(1) Expression of glyA, encoding serine hydroxymethyltransferase activity, was elevated in a purR mutant compared with a wild-type strain.
(2) A bulldozer on rail wheels purrs up on the other line and begins pawing at the stones.
(3) At the place where adorable meets obnoxious and the purr becomes a shriek, Leslie Mann is waiting to unload a howitzer of funny in your face.
(4) Nitrogen control was found to be mediated by the glnLG gene products, and purine repression required a functional purR gene product.
(5) Though I could have sworn that you did actually purr,” Dave recalled.
(6) AMP but not GMP is needed for binding, and purR mutants are deficient in the binding substance.
(7) The PurR protein bound specifically to a DNA fragment carrying the glyA control region, as determined by gel retardation.
(8) Cross pathway regulation of pyrC by PurR may provide one mechanism to coordinate synthesis of purine and pyrimidine nucleotides.
(9) "Oh, the lords absolutely love Justin," purrs one senior peer.
(10) Both operator constitutive and repressor type (purR) mutations have been identified.
(11) The purR product functions in the common control of several genetically distinct enzymes that participate before the formation of IMP.
(12) The regulation of the guanine operon is regulated by some other mechanism independent of purR.
(13) A highly conserved sequence in the promoter regions of these two genes is similar to the pur operator, which is the binding site for the purine repressor (PurR).
(14) Gene purB is regulated threefold by the purine pool and purR.
(15) The purEK operon is regulated by the purR gene product, and a purR regulatory-protein-binding site related to the sequences found in other pur loci was identified in the purEK operon control region.
(16) In the film, there is a killingly funny vignette in which Joshua McGuire’s Ruskin, who cannot pronounce his Rs, purrs with self-satisfaction at his own ideas – the critic who got the cream.
(17) Analysis of a purR-lacZ transcriptional fusion indicated that purR expression is autoregulated.
(18) Mutations that changed the binding sequence toward the consensus sequence had no significant effect on either PurR binding or purine-mediated repression.
(19) Site-directed mutagenesis was used to change the PurR binding site in the control region of a glyA-lac gene fusion.
(20) Two independent purR mutations were isolated which abolished repression of purF and purF-lacZ.