(a.) Producing heat; -- said of substances, as septic poisons, which elevate the temperature of the body and cause fever.
Example Sentences:
(1) Central injections of 40 and 80 ng of [Nle4,D-Phe7]-alpha-MSH caused hypothermia in afebrile rabbits, whereas 20 and 10 ng, which had no effect on afebrile body temperature, caused greater than 40% reduction in leukocytic pyrogen-induced fever.
(2) In the active phase all the patients exhibited an abrupt increase in the activity of alkaline and acid phosphatase in blood neutrophils, a drop in the level of CP (in 69%), a rise in the activity of MP (in 32%); pyrogenal did not induce any capacity for restoring HCT (in 44%).
(3) MAbs W1-W3 derived from mice, which were immunized with whole cells of the strain Moulton, reacted with the serogroups Canicola, Icterohaemorrhagiae and Pyrogenes.
(4) Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are thought to be endogenous pyrogens, i.e., to mediate fever production; warm-sensitive (W) and cold-sensitive (C) neurons in the preoptic area (POA) are presumed to be the ultimate targets of endogenous pyrogens.
(5) The Limulus amebocyte lysate test has been used for determination of pyrogens in sugar of different qualities.
(6) The minimum pyrogenic dose in both new-born and adult guinea-pigs was 0.25 microliter, but the 0 to 5-day old animals which responded with a fever to this dose were few in number and large in weight; 'small-for age' neonates became hypothermic.
(7) Twelve serovars included in the study were: australis, autumnalis, ballum, bataviae, bratislava, canicola, copenhageni, grippotyphosa, hardjo, pomona, pyrogenes, and tarassovi.
(8) Another property shared by IL 1 and IL 6 is their pyrogenicity.
(9) IL-6 induction was also observed after pretreatment with indomethacin, indicating that the effect was dissociated from the pyrogenic activity of IL-1.
(10) Protein malnutrition leads to diminished pyrogenicity of macrophage culture supernatants and may be at least partly responsible for the decreased febrile response seen in the malnourished animals.
(11) In its monomer form, endogenous pyrogen is a potent fever-producing substance and mediates fever by its action on the thermoregulatory center.
(12) Immobilized histidine and immobilized histamine could be used for the removal of natural pyrogens contaminating various useful low-molecular-weight compounds as well as high-molecular-weight compounds such as proteins.
(13) Reusing hemodialyzers more than 20 times and, in some instances, also using manual reprocessing systems was significantly associated with clustering of pyrogenic reactions regardless of the type of germicide used.
(14) The effects of various kinds of drugs on the pyrogenicity of toxic shock syndrome toxin 1 (TSST-1) and its capacity to enhance the lethal effects of endotoxin in rabbits were studied.
(15) The hyperthermic response to pyrogen was not potentiated by caffeine or theophylline administered i.p.
(16) With regard to Group I, there was a high number of positive (32.3%) and a variation in the frequency of serovars, the results being as follows: L. butembo (38.8%), L. pomona (33.3%), L. bratislava (31.4%), L. icterohemorragica (12.9%), L. borincana (3.7%) and finally L. canicola, L. pyrogenes, L. wolffii and L. bataviae (1.8%).
(17) Parenterals, sterile preparations intended to be injected in man or animal, should be free from pyrogenic substances which are able to raise the thermostatic setting in the hypothalamus.
(18) Titers for Leptospira interrogans serovars grippotyphosa, pyrogenes, djasiman, butembo, and pomona were demonstrated.
(19) The fever responses of the animals were remeasured 3 days later, and in every case there was a marked enhancement of the fevers produced, using the same doses of endogenous pyrogen that were used earlier.
(20) The results were compared with rabbit pyrogen tests.
Pyroxenic
Definition:
(a.) Containing pyroxene; composed chiefly of pyroxene.
Example Sentences:
(1) A laboratory study of the interaction of H2O frost with samples of the minerals olivine (Mg,Fe)2SiO4 and pyroxene (Mg,Fe)SiO3 at -11 degrees C to -22 degrees C revealed that an acidic oxidant was produced.