(n.) A colorless liquid of a slightly pungent odor, C9H6N.CH3, first obtained as a condensation product of aldehyde and aniline, and regarded as a derivative of quinoline; -- called also methyl quinoline.
Example Sentences:
(1) In addition, some quinaldine red may be present in the cytoplasm in an aggregated, ionically bound form.
(2) The following degradation products of quinaldine were isolated from the culture fluid and identified: 1H-4-oxoquinaldine, N-acetylisatic acid, N-acetylanthranilic acid, anthranilic acid, 3-hydroxy-N-acetylanthranilic acid and catechol.
(3) However, uptake as well as subsequent ionic binding of quinaldine red seems to be related to potential in an as yet undefined manner.
(4) A major aspect of the change is that in sodium-loaded cells, essentially all of the quinaldine red accumulated as the result of energization forms a strong bond with an anionic group.
(5) 4-(2'-, 4'-nitro- and 2',4'-dinitrobenzenesulfenamido)-quinaldines (I--III) as well as 2-(2'-,3'-nitro and 2',4'-dinitrobenzensulfenamido)-46-oimethylpyrimidines (IV--VI) were obtained.
(6) 2-Hydroxymethylquinoline and quinaldine are found in nonfresh greyhound urine as putrefactive bases.
(7) 2-aminomethylquinoline is excreted in fresh urine and two others, quinaldine and 2-hydroxymethylquinoline, are formed as the urine decays.
(8) The determination of dichloralantipyrine is based on the fact that it, as well as its major metabolite chloral hydrate, produces a blue color with quinaldine ethiodide.
(9) Solvent Yellow 33 (German: Rauchgelb) belongs to the groups of quinaldine dyes which are produced by condensing quinaldine and phthalic anhydride.
(10) The general characteristics of the cation employed, quinaldine red, closely paralleled those of other amphiphilic cations which have been used to measure membrane potential.
(11) The aggregates were estimated to contain at least five quinaldine red cations at or near van der Waals contact, and the presence of other molecules, such as phospholipids, could not be excluded.
(12) Quinaldine catabolism was investigated with the bacterial strain Arthrobacter sp., which is able to grow aerobically in a mineral salt medium with quinaldine as sole source of carbon, nitrogen and energy.
(13) Type A monoamine oxidase (MAO-A) in human placental mitochondria was competitively inhibited by naturally occurring substances, quinoline and quinaldine, using kynuramine as substrate.
(14) This binding is similar to that which occurs for the basal level of quinaldine red taken up in nonenergized cells.
(15) Uptake of the anesthetics tricaine methanesulfonate, benzocaine, Piscaine, and quinaldine is rapid because they are lipophilic.
(16) Production of 2-hydroxymethylquinoline or quinaldine is not arrested but merely retarded by preservation or refrigeration.
(17) The results show that membrane potential cannot be computed in a simple manner from the distribution of quinaldine red between cells and medium, assuming that the thermodynamic activity coefficient of cell-localized material is identical with that in dilute aqueous solution.
(18) The dithioacetic acid zwitterions were prepared from the base-catalyzed reaction of carbon disulfide with quinaldine and picoline methiodides, and the bis(methylthio) derivatives resulted from reaction with methyl iodide at room temperature.
(19) A method for the measurement of quinaldine and 2-hydroxymethylquinoline using gas chromatography is described.
(20) 2-Hydroxymethylquinoline forms in greyhound urine, if non-preserved, in three or four days at room temperature while quinaldine takes as much as 10 days longer to form.
Quinoline
Definition:
(n.) A nitrogenous base, C9H7N obtained as a pungent colorless liquid by the distillation of alkaloids, bones, coal tar, etc. It the nucleus of many organic bodies, especially of certain alkaloids and related substances; hence, by extension, any one of the series of alkaloidal bases of which quinoline proper is the type.
Example Sentences:
(1) The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed in vitro.
(2) The quinolinate synthetase B protein exists in all nadA and nadC mutants examined.
(3) Unilateral infusions of quinolinic acid (QUIN) into the rat striatum led to an increase in cholecystokinin octapeptide sulfate-like immunoreactivity (CCK8S-LI) in the striatum and substantia nigra 4 days later.
(4) A histochemical method for staining CNS zinc by the stoichiometric formation of zinc: quinoline fluorescent chelates is described.
(5) In contrast to other excitotoxins, such as kainic acid, quinolinic acid (QA) may spare a specific population of striatal neurons that is also spared in Huntington's disease (HD).
(6) Previous studies have shown that in lipopolysaccharide (LPS)-stimulated human monocytes, interleukin 1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.
(7) We conclude that quinolinic acid causes both reversible and long-lasting gliosis when injected into the rat striatum.
(8) The enzymic and non-enzymic formation of protein-arylating intermediates from amodiaquine (AQ,7-chloro-4-(3'-diethylamino-4'-hydroxyanilino) quinoline), an anti-malarial associated with agranulocytosis and liver damage in man, was studied in vitro.
(9) The ability of quinolinic acid to produce neurotoxicity was greater in the striatum than in other parts of the brain.
(10) The behavioral effects of 2-p-chlorophenylpyrazolo[4,3-c]quinolin-3(5H)-one (CGS 9896) were compared with those of lorazepam and zopiclone in squirrel monkeys.
(11) Synthetic heterocyclic quinones (107 samples) consisting of o- and p-quinoline quinones, o-isoquinoline quinones and p-quinoxaline quinones as well as o- and p-naphthoquinones (3 samples) were tested for their inhibitory activities against avian myeloblastosis virus reverse transcriptase (AMV-RT) and cytotoxic activities against mouse lymphoblastoma L5178Y cells.
(12) Ibotenate lesioned rats, despite having larger lesions than the quinolinate, showed no deficits in eating or drinking in the home cage, or reaching or grasping disabilities in the staircase test.
(13) Between the other toxins (kainate, AMPA, ibotenate, quisqualate, NMDA and the high dose of quinolinate) there were no statistically significant differences.
(14) possess anticonvulsant action against kynurenine and not against quinolinic acid.
(15) The quinoline nitrogen atom of quipazine also contributes to affinity and its replacement by carbon reduces affinity by 20-fold.
(16) The localization and distribution of quinolinic acid phosphoribosyltransferase, the degradative enzyme of the endogenous excitotoxin quinolinic acid, were studied in the post mortem human neostriatum by immunohistochemistry.
(17) The quinoline-containing antimalarial drugs chloroquine, quinine and mefloquine exert an irreversible inhibitory effect on erythrocytic stages of Plasmodium falciparum grown in culture.
(18) Bilateral intrastriatal injections of quinolinic acid (QA) (180 nmoles) induced weight loss and neurologic and behavioral deficits including convulsions, decreased catalepsy response to haloperidol, increased nocturnal locomotor activity, and abnormal feeding behavior in adult male Sprague-Dawley rats.
(19) Kainic acid and quinolinic acid were also effective in increasing the AAT activity.
(20) Diabetogenic and acidotropic effects of dithizone, 8-(p-toluenesulfonylamino)-quinoline and 8-(benzenesulfonylamino)-quinoline were studied in experiments on cats, rabbits, golden hamsters and mice.