What's the difference between quinidine and quinine?
Quinidine
Definition:
(n.) An alkaloid isomeric with, and resembling, quinine, found in certain species of cinchona, from which it is extracted as a bitter white crystalline substance; conchinine. It is used somewhat as a febrifuge.
Example Sentences:
(1) The antiarrhythmic activity similar to that of quinidine (with ca.
(2) Antihistone antibodies, which are characteristic of drug-induced lupus erythematosus associated with procainamide and hydralazine therapy, were detected in all patients with quinidine-induced lupus erythematosus.
(3) It is felt that the use of quinidine was causally related to the development of nephrotic syndrome in this patient.
(4) Microsomal metabolites were also isolated from quinine and quinidine incubations with rabbit or guinea pig liver fractions.
(5) Six healthy male subjects received single oral doses of regular release (RR) quinidine sulfate, sustained release (SR) quinidine bisulfate and the same dose of the SR product with food (SR-F).
(6) Quinidine gluconate 324 mg sustained release tablets (Quinaglute) was administered as a single dose to 15 healthy male subjects following an overnight fast, immediately following a high fat (HF) breakfast or immediately following a low fat (LF) breakfast.
(7) 1 The actions of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI) and quinidine were compared on guinea-pig heart preparations.
(8) Extracardiac adverse effects of quinidine include potentially intolerable gastrointestinal effects and hypersensitivity reactions such as fever, rash, blood dyscrasias and hepatitis.
(9) Studies in normal volunteers have shown that areas under the serum concentration-time curve of orally administered quinidine are higher when quinidine is given during chronic cimetidine therapy as compared to under control conditions.
(10) Mild to moderate renal dysfunction is less likely to lead to quinidine or disopyramide intoxication, unless renal failure is severe or concurrent hepatic dysfunction is present.
(11) Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells.
(12) The clinical application of the method for routine drug monitoring and for estimating the pharmacokinetics of quinine and quinidine in man are discussed.
(13) As regards inhibition, on the other hand, there is now considerable information available which indicates that omeprazole has the potential to partly inhibit the metabolism of drugs metabolised to a great extent by the cytochrome P450 enzyme subfamily IIC (diazepam, phenytoin), but not of those metabolised by subfamilies IA (caffeine, theophylline), IID (metoprolol, propranolol) and IIIA (cyclosporin, lidocaine, quinidine).
(14) Quinidine and procainamide but particularly the last two agents also markedly prolonged overdrive suppression.
(15) Although the ventricular effective refractory period measured with a conventional basic drive train duration of eight beats is often more than 20 msec longer than the actual ventricular effective refractory period measured with a drive train duration of 3 minutes, the effects of quinidine and mexiletine on the conventionally measured ventricular effective refractory period accurately reflect the effects of these drugs on the actual ventricular effective refractory period.
(16) Efforts were directed towards sensitizing CML cells to ADR and mitoxanthrone (MITO) cytotoxicity by employing quinidine, an antiarhythmic agent.
(17) A partial depolarization of the resting membrane by increasing extracellular potassium concentration ([K+]o) from 4 to 8 mM potentiated UDB at 2 Hz stimulation by any of the following drugs: pirmenol (10 microM), disopyramide (20 microM), pentisomide (50 microM), quinidine (20 microM), mexiletine (30 microM), and flecainide (5 microM).
(18) It is concluded that different potencies among these beta-adrenoreceptor antagonists against various kinds of experimental arrhythmias cannot be simply deduced from any one of the following properties; beta-adrenoreceptor antagonism, intrinsic myocardial stimulation, local anaesthetic and so-called quinidine-like effects.
(19) Identity, reproducibility and accuracy of the theophylline and quinidine concentrations measurement using fluorescence-polarization immunoassay constituted 1.4-3.5%, 2.0-8.5% and 95-109%, respectively, thus satisfying the high requirements and were superior as compared with corresponding parameters of the enzyme immunoassay.
(20) Theophylline may also affect quinidine CLi by inhibiting the carrier-mediated pathway.
Quinine
Definition:
(n.) An alkaloid extracted from the bark of several species of cinchona (esp. Cinchona Calisaya) as a bitter white crystalline substance, C20H24N2O2. Hence, by extension (Med.), any of the salts of this alkaloid, as the acetate, chloride, sulphate, etc., employed as a febrifuge or antiperiodic. Called also quinia, quinina, etc.
Example Sentences:
(1) The influence of the hexylsalicylic acid (2) on the pharmacokinetic of the quinine (1), was studied using rabbits.
(2) Concomitant with the inhibition of K+ and Na+ transport, quinine stimulates ATP hydrolysis by 57%.
(3) those that had entered the G1 phase) expressed an increased amount of Fc gamma RII and (b) blocking the entry of activated cells into the S phase (with the ion channel blocker quinine) did not affect the Fc gamma RII induction by LPS.
(4) It was found that DI rats responded less than LE rats on the progressive-ratio schedule and that DI rats suppressed drinking as much as LE rats at each concentration of quinine used on the drinking-suppression test.
(5) Microsomal metabolites were also isolated from quinine and quinidine incubations with rabbit or guinea pig liver fractions.
(6) A nearly complete blockade of channel current was observed at 100 nM quinine and above.
(7) Treatment may be delayed because the therapy recommended for severe or complicated disease, intravenous quinine dihydrochloride, is available only from the Centers for Disease Control.
(8) Cell proliferation was equally sensitive to quinine regardless of mitogen.
(9) The responses to quinine and mefloquine or halofantrine showed no correlation with each other.
(10) The CGRP-IR levels in the rostral (gustatory) part of the insular cortex were increased significantly by strongly aversive taste stimuli such as quinine hydrochloride and conditioned taste stimuli (NaCl and sucrose) which animals had been taught to avoid.
(11) Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells.
(12) Despite the presence in the region of an important resistance of Plasmodium falciparum to chloroquine (80% specimens), one can conclude to a satisfying susceptibility of this parasite to quinine, provided posology and divided doses are respected.
(13) The clinical application of the method for routine drug monitoring and for estimating the pharmacokinetics of quinine and quinidine in man are discussed.
(14) The resistance of Plasmodium falciparum, the cause of tertian malaria, to synthetic antimalarials, together with the resistance of the vector mosquitoes to insecticides, has resulted in a resurgence in the use of quinine and a search for new antimalarial agents.
(15) all infections were sensitive to quinine plus tetracycline.
(16) Quinine applied on the intracellular side of the membrane in micromolar concentrations chopped the unitary K+ currents into bursts of brief openings.
(17) This was shown by a dye exclusion test and by mitogen stimulation after exposure and removal of quinine from the medium.
(18) These are insensitive to quinine, suggesting that they are not caused by an intracellular Ca accumulation.
(19) The spread of chloroquine-resistant malaria has led to a resurgence of quinine in clinical use.