(n.) An alkaloid extracted from the bark of several species of cinchona (esp. Cinchona Calisaya) as a bitter white crystalline substance, C20H24N2O2. Hence, by extension (Med.), any of the salts of this alkaloid, as the acetate, chloride, sulphate, etc., employed as a febrifuge or antiperiodic. Called also quinia, quinina, etc.
Example Sentences:
(1) The influence of the hexylsalicylic acid (2) on the pharmacokinetic of the quinine (1), was studied using rabbits.
(2) Concomitant with the inhibition of K+ and Na+ transport, quinine stimulates ATP hydrolysis by 57%.
(3) those that had entered the G1 phase) expressed an increased amount of Fc gamma RII and (b) blocking the entry of activated cells into the S phase (with the ion channel blocker quinine) did not affect the Fc gamma RII induction by LPS.
(4) It was found that DI rats responded less than LE rats on the progressive-ratio schedule and that DI rats suppressed drinking as much as LE rats at each concentration of quinine used on the drinking-suppression test.
(5) Microsomal metabolites were also isolated from quinine and quinidine incubations with rabbit or guinea pig liver fractions.
(6) A nearly complete blockade of channel current was observed at 100 nM quinine and above.
(7) Treatment may be delayed because the therapy recommended for severe or complicated disease, intravenous quinine dihydrochloride, is available only from the Centers for Disease Control.
(8) Cell proliferation was equally sensitive to quinine regardless of mitogen.
(9) The responses to quinine and mefloquine or halofantrine showed no correlation with each other.
(10) The CGRP-IR levels in the rostral (gustatory) part of the insular cortex were increased significantly by strongly aversive taste stimuli such as quinine hydrochloride and conditioned taste stimuli (NaCl and sucrose) which animals had been taught to avoid.
(11) Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells.
(12) Despite the presence in the region of an important resistance of Plasmodium falciparum to chloroquine (80% specimens), one can conclude to a satisfying susceptibility of this parasite to quinine, provided posology and divided doses are respected.
(13) The clinical application of the method for routine drug monitoring and for estimating the pharmacokinetics of quinine and quinidine in man are discussed.
(14) The resistance of Plasmodium falciparum, the cause of tertian malaria, to synthetic antimalarials, together with the resistance of the vector mosquitoes to insecticides, has resulted in a resurgence in the use of quinine and a search for new antimalarial agents.
(15) all infections were sensitive to quinine plus tetracycline.
(16) Quinine applied on the intracellular side of the membrane in micromolar concentrations chopped the unitary K+ currents into bursts of brief openings.
(17) This was shown by a dye exclusion test and by mitogen stimulation after exposure and removal of quinine from the medium.
(18) These are insensitive to quinine, suggesting that they are not caused by an intracellular Ca accumulation.
(19) The spread of chloroquine-resistant malaria has led to a resurgence of quinine in clinical use.
(20) Whether it was Sénac or Wenckebach who first observed that quinine could change an irregular heart rhythm (atrial fibrillation) into a regular one (sinus rhythm), we are not far from their empiricism.
Quintine
Definition:
(n.) The embryonic sac of an ovule, sometimes regarded as an innermost fifth integument. Cf. Quartine, and Tercine.
Example Sentences:
(1) In 1963, when Tony Benn won his fight to renounce his inherited peerage, he was rapidly followed by Quintin Hogg and Alec Douglas-Home, who were prominent in the Lords but understood they needed to face the people to get to the very top, as Douglas-Home went on to do.
(2) Here's Quintin Berry, and if the Tigers can't score here...well... 1.53am GMT Giants 2 - Tigers 0, Bottom 5th A little flare by Infante finds a little bit of room out on right field, and that really is all you need.
(3) Quintin Price, a former manager at investment management firm BlackRock, will join the management board to lead Deutsche’s assetmanagement business, while the current head Michele Faissola will leave the bank.
(4) Meanwhile Quintin Mikell is questionable with a foot injury and his return is questionable.
(5) But the director general of the European commission, Odile Quintin, yesterday acknowledged that the EU was divided on the issue, and that the position, for now at least, was that the word "apology" would not be used.
(6) Both Hogg’s parents had leading roles in Sir John Major’s government and her grandfather, Quintin Hogg, was a prominent Tory who almost won the Conservative party leadership following the resignation of Harold Macmillan.
(7) She did not disclose her brother Quintin’s role at Barclays – regulated by the Bank – until 22 February when she filled in a questionnaire from the Treasury select committee before her evidence about her promotion to deputy governor.
(8) Now Quintin Berry will hit for the pitcher, and he chops to Scutaro at second and just gets the out at first, side retired!
(9) 12.28am GMT Giants 0 - Tigers 0, Bottom 1st Quintin Berry is up next and he works a full count off of Cain, fouls a few balls off, gets Cain to throw eight pitches and then lines a ball... *JUST* foul into the corner.
(10) 1.12am GMT Giants 1 - Tigers 0, Bottom 3rd Quintin Berry bunts, and Cain and Sandoval nearly collide in trying to field it, and Sandoval gets the ball and manages to just throw out Berry at first.
(11) So we have two runners on and just one out for Quintin Berry.
(12) Emwazi was educated at another school in the area, Quintin Kynaston (QK), where his contemporaries included the singer-songwriter Tulisa.
(13) Her parents had leading roles in Sir John Major’s government and her grandfather, Quintin Hogg, better known as Lord Hailsham, was a prominent Tory who almost won the Conservative party leadership after the resignation of Harold Macmillan in 1963.
(14) Bank of England deputy's slip-up was astonishing – but its reaction was predictable | Nils Pratley Read more Hogg’s troubles began when it emerged that she had not declared a potential conflict of interest , which is that her brother, Quintin Hogg, is a director of group strategy at Barclays, which the Bank of England regulates.
(15) A scion of one of Britain’s most high-profile political families, Hogg had initially told MPs last month that the Bank was aware of Quintin Hogg’s role at the high street lender.
(16) 7.32pm GMT 49ers 6-10 Panthers, :42, 2nd quarter Carolina's Quintin Mikell was injured on the last play, looks like the ankle.
(17) The lengthy beer menu lists 170 brews, including hard-to-find local specialities such as Quintine beers from the witches’ town of Ellezelles (which claims to be birthplace of Hercule Poirot, solely on the basis of a fake birth certificate) and lovely spicy, unfiltered La Chouffe on tap.
(18) 2.56am GMT Giants 3 - Tigers 3, Bottom 8th Pinch-hitting for the Tigers for Quintin Berry is Avisail Garcia.
(19) Then we have trouble, a one-out walk to Quintin Berry, which means the meat is coming up with a man on.
(20) 1.51am GMT Giants 1 - Tigers 2, Bottom 5th Quintin Berry hits a grounder that Cain can't get a handle on but, it gets to Crawford who throws to Belt just in time to get the out and end the inning.