(n.) Rent or worn into tatters, or till the texture is broken; as, a ragged coat; a ragged sail.
(n.) Broken with rough edges; having jags; uneven; rough; jagged; as, ragged rocks.
(n.) Hence, harsh and disagreeable to the ear; dissonant.
(n.) Wearing tattered clothes; as, a ragged fellow.
(n.) Rough; shaggy; rugged.
Example Sentences:
(1) Over the past 20 years the rag-and-bone trade has had a makeover.
(2) I usually use them as a rag with which to clean the toilet but I didn’t have anything else to wear today because I’m so fat.” While this exchange will sound baffling to outsiders, to Brits it actually sounds like this: “You like my dress?
(3) Confluent monolayers of capillary endothelial cells derived from Mongolian gerbil brain were irradiated with a single exposure of x-rays, and their radiosensitivity and sequential changes in morphology, staining intensity for factor VIII-related antigen (F VIII RAg), and capacity to produce prostacyclin (PGI2) were examined.
(4) Skeletal muscle mtDNA of three patients with mitochondrial encephalomyopathy, characterized clinically by myoclonic epilepsy and ragged-red fiber (MERRF) syndrome, has been sequenced to determine the underlying molecular defect(s).
(5) A distinctive pattern of subsarcolemmal mitochondrial aggregates, referred to as "ragged red fibers" in human mitochondrial myopathies, was observed in muscle biopsy samples from 1 dog.
(6) Endothelial cells of capillary vessels showed positive binding by UEA-1 lectin and the presence of factor VIII RAG.
(7) Four of the mutants had no effect on chylous ascites, but two mutants linked with ragged, and one unlinked, showed a complex situation involving enhancement, inhibition, epistacy and other interactions.
(8) There was a slight shortening in the thrombin time and a smaller increase in post-operative FVIII RAg and FVIII RCof levels in the HES group.
(9) There was no correlation between FVIII:RAg levels and radiation pneumonitis, radiation dose, volume of irradiated lung, tumor burden, or time-interval between exposure and sampling.
(10) In one of these, a probe designed specifically to detect deleted mtDNA identified abundant deleted mtDNA and its fusion transcript in RRF and lesser accumulations in non-ragged red cytochrome oxidase (COX) deficient fibres.
(11) Only in fragments of the biceps brachii muscle histological and histochemical investigations showed mitochondrial changes of the type of "ragged-red fibres".
(12) In situ hybridization to intact thymus and RNA blot analysis of isolated thymic subpopulations separated on the basis of T cell receptor (TCR) expression demonstrated that both TCR- and TCR+ cortical thymocytes express RAG-1 and RAG-2 messenger RNA's.
(13) Nuclear run-on assays showed that TPA completely repressed the transcription of RAG-1 within 30 min.
(14) A former Socialist party leader, he is a jovial, wise-cracking believer in consensus politics, who aides say never loses his rag and who so hates fights that he was once nicknamed "the marshmallow" within his own party, or "Flanby", after a wobbly caramel pudding.
(15) The Farage adviser said he looked back on many people within Ukip as “a bunch of rag-tag, unprofessional, embarrassing people who let Nigel down at every juncture.” He told the Guardian: “Someone needs to go in there with a big stick.
(16) Furthermore, we show that RAG can be expressed not only by CD3-TCR negative but also by CD3-TCRab or gd positive T-ALL cells.
(17) After fusion of HPRT- RAG cells with E. lutescens fibroblasts we demonstrated that the enzymes HPRT and G6PD are localized on the presumptive X chromosome.
(18) We analyzed the mitochondrial DNA of blood cells of 5 patients from a Chinese family with myoclonic epilepsy and ragged-red fiber disease.
(19) A small percentage of peripheral B cells also contained RAG-1 mRNA, raising the possibility that this protein may also be involved in immunoglobulin class switching.
(20) Exposure of isolated thymocytes to 12-O-tetra-decanoylphorbol 13-acetate (TPA)+ionomycin rapidly abolishes the expression of recombination-activating gene-1 (RAG-1) mRNA (3 h), down-regulates CD4 surface antigen expression (3 h), and enhances apoptosis (24 h).
Rugged
Definition:
(n.) Full of asperities on the surface; broken into sharp or irregular points, or otherwise uneven; not smooth; rough; as, a rugged mountain; a rugged road.
(n.) Not neat or regular; uneven.
(n.) Rough with bristles or hair; shaggy.
(n.) Harsh; hard; crabbed; austere; -- said of temper, character, and the like, or of persons.
(n.) Stormy; turbulent; tempestuous; rude.
(n.) Rough to the ear; harsh; grating; -- said of sound, style, and the like.
(n.) Sour; surly; frowning; wrinkled; -- said of looks, etc.
(n.) Violent; rude; boisterrous; -- said of conduct, manners, etc.
(n.) Vigorous; robust; hardy; -- said of health, physique, etc.
Example Sentences:
(1) The hosts had resisted through the early stages, emulating their rugged first-half displays against Manchester United and Arsenal here this season, and even mustered a flurry of half-chances just before the interval to offer a reminder they might glean greater reward thereafter.
(2) Steps wind down a rugged rock face to a bedroom, while light floods in from round skylights in the domed ceiling above.
(3) The Turner prize-winning artist has turned his sights on the survivalist and his exceptionally rugged version of masculinity, arguing that it isn’t fit for the 21st century.
(4) Many survivors use it to get the accommodations needed to stay in school, while others used it to hold their institutions accountable for sweeping sexual assault under the rug.” More than two dozen states are suing the Obama administration over its guidance on transgender students in an effort that is overwhelmingly led by Republican secretaries of state.
(5) As the president of Russia's Kalmykia republic from 1993 to 2010, Ilyumzhinov undoubtedly has close ties to the Kremlin, and a woven rug featuring Putin's face hangs in his office.
(6) Also, a wildfire in a rugged area near the Canadian border chased hundreds of people from their homes and burned 10 to 12 structures, and a blaze north-east of Colville scorched almost five square miles and forced evacuations at campgrounds in the area.
(7) Allergenic proteins were extracted from one silk batch that was imported to be used as filling material for bed mattresses and rugs.
(8) And reporting by the Observer reveals the extent to which al-Qaida has integrated itself with powerful tribes that control large swaths of Yemen's rugged east and parts of its south.
(9) FIVE MORE FRENCH COASTAL GEMS Marseille grotto Facebook Twitter Pinterest Photograph: Alamy A 40-minute walk from Marseille’s Luminy university campus, Calanque de Sugiton, the most picturesque of the city’s rugged, limestone coves has blue-green waters, twisted pine trees and a narrow island-rock to swim out to known as Le Torpilleur.
(10) Laminin and its E1-4 and E8 fragments are able to activate the ecto-5'-nucleotidase activity of both BCS-TC2 and Rugli cells.
(11) Pictures of the young Depardieu in a good light suggest a rugged, brooding, if not classically good-looking man with a squared chin and mop of blonde hair.
(12) In the presence of glucose oxidase and trien this polymer forms rugged, cross-linked, electroactive films on the surface of electrodes, thereby eliminating the requirement for a membrane for containing the enzyme and redox couple.
(13) The tone was set in the second minute when Ben Westwood, Warrington's notoriously rugged forward, left the Wigan stand-off Blake Green on the ground needing lengthy treatment.
(14) The simple design and rugged construction permit the incorporation of the apparatus into many manual or personal computer controlled oxygen consumption systems.
(15) Both offer lodges and campsites, but keep in mind that only a very small fraction of these remote and rugged parks are accessible by road.
(16) "When a similar report was released in 2009, the Administration largely swept it under the rug.
(17) La Posada has undergone a $12m renovation, transforming it into a magical place with handmade Mexican tin and tile mirrors, six-foot cast iron tubs, hand woven Zapotec rugs, and hand-painted furniture and tile murals.
(18) These assays have proven to be accurate, precise, reproducible, and rugged during clinical sample analyses.
(19) And cutting support now would take demand out of the economy, pull the rug from under the recovery, and delay our return to sustained growth.
(20) Chelsea had laboured at times without him in that first period, Begovic denying them reward from an urgent opening and Stoke rugged and organised until self-destructing with half-time in sight.