(1) The effects of hormonal promotion of T24-ras oncogene-transfected rat embryo fibroblasts (REF) were compared to cotransformation of these cells with adenovirus E1A and ras.
(2) Large gender differences were found in the correlations between the RAS, CR, run frequency, and run duration with the personality, mood, and locus of control scores.
(3) Here we co-inject RB protein with c-myc, EJ-ras, c-fos or c-jun protein.
(4) These results suggest that a certain minimum level of expression of c-myc is required for the maintenance of ras transformation in NIH 3T3 cells.
(5) This is the first clear example of activation of the K-ras gene by ethylating agents in a rodent lung tumor system.
(6) A total of 28 cell lines were selected for Geneticin - resistance and inoculated into the footpads of syngeneic animals following co-transfection with pSV2neo and genomic DNA, or transfection with plasmid constructs containing neo and the activated Ha-ras oncogene.
(7) In the second study, CFA, TiterMax, Adjuvax and RAS were compared in rabbits, mice and goats.
(8) One week after initiation is 1-2 months before the appearance of benign papillomas that harbor activated Ha-ras oncogenes when the initiated mice are promoted with the tumor promoter phorbol 12-myristate 13-acetate.
(9) The other three oncogenes namely c-K-ras, c-H-ras and c-myc, were not detected in these two carcinomas or the non-cancerous liver tissue adjacent to the carcinomas.
(10) Thus, a4 and a2 alleles of the c-Ha-ras-1 may perhaps be viewed as genetic markers of predisposition to lung, ovarian and thyroid cancer, respectively, in combination with other clinical parameters.
(11) Additionally, the amount of mRNAs for preproenkephalin as well as for the cellular proto-oncogenes c-myc, c-fos and c-H-ras, which are thought to be mediators of intracellular signal transduction, was determined in hippocampus in these same animals.
(12) The degree of staining for ras 11 was significantly related to the grade of differentiation and increased from Dukes stage A to C. Strong staining for ras 11 predicted a significantly shorter recurrence-free interval (p less than 0.001).
(13) The effects of oxidant stress were studied in immortalised hamster (BHK-21) and rat (208F) cell lines before and after transformation to the malignant state with polyoma virus, or activated H-ras, respectively.
(14) Upon stimulation with NGF, the percentage of Ras.GTP increased to 24% after 2 min, and the high level of Ras.GTP was maintained for at least 16 h. On the other hand, the activation of Ras by FGF and IL-6 showed distinct kinetics; about 3-fold increase of Ras.GTP was detected at 10 min, and afterward, the level returned to the basal level within 60 min.
(15) Transfection with normal and activated C-H-ras oncogenes only led to increases in the IC50s of alkylating agents.
(16) These cell lines also overexpress the Ha-ras proto-oncogene.
(17) In one patient with gastric carcinoma a c-Ha-ras-1 overexpression was detected due to its amplification both in tumour tissues and in regional metastasis.
(18) Our study gives further evidence that erb B, myc, Ha-ras and fos proto-oncogenes are involved in the control of cell growth and in the process of rat hepatocarcinogenesis.
(19) The Wap-ras gene was stably introduced into the mouse germ line of five transgenic mice (one male and four females).
(20) These results suggest that ras, fos, mos, src, and erbB-2 use a common cellular pathway for transforming cells.
Rasp
Definition:
(v. t.) To rub or file with a rasp; to rub or grate with a rough file; as, to rasp wood to make it smooth; to rasp bones to powder.
(v. t.) Hence, figuratively: To grate harshly upon; to offend by coarse or rough treatment or language; as, some sounds rasp the ear; his insults rasped my temper.
(v.) A coarse file, on which the cutting prominences are distinct points raised by the oblique stroke of a sharp punch, instead of lines raised by a chisel, as on the true file.
(v.) The raspberry.
Example Sentences:
(1) There were two recipient-site complications, with one case of complete bone resorption that occurred in a densely fibrotic nose with preexisting septal perforation and a case of overcorrection that was successfully rasped 1 year later.
(2) 8.46pm BST 44 min: Joe Allen tries to double his tally of career goals for Liverpool with a rasping effort from the corner of the penalty area.
(3) A cigarette dangled from my lips as I rasped away at the audience.
(4) Sunderland were back in it after only 16 minutes, when that dodgy back line went awol as John Mensah headed in Andy Reid's cross, then equality was restored by Henderson's rasping finish.
(5) Both laboratory tests on variously prepared specimens of cement and clinical experiences demonstrate that recementing over old cement is a practical alternative if the technique employed includes the removal of blood from the old cement surface, rasping of this surface and the early application of fresh cement.
(6) "It was stupid," she says, in her distinctive Mediterranean rasp.
(7) In a subsequent series of 68 patients (52 males, 16 females) who had 81 meniscal repairs by means of the rasp for parameniscal synovial abrasion, the failure rate was 9%.
(8) Not for Andreas Baader, Ulrike Meinhof, Gudrun Ensslin and Jan-Carle Raspe, who are all dead.
(9) Vardy scored one and he might have added a second with a rasping drive after the break.
(10) Repeated noise at 1-4 cycles per second evokes an effortless heard rhythmic sensation which is often heard as "clanks" and "rasping."
(11) So, Rasping procedure was effective for type I and type II valve degeneration.
(12) We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol.
(13) By the latter half of the decade, her body was wasted, her voice weathered down to a hoarse rasp, and Strange Fruit was the only song that seemed to dignify her suffering, wrapping her own decline in a wider American tragedy.
(14) He drops a shoulder, cuts inside, and unleashes a rasping, rising drive, the ball only just missing the top-right corner.
(15) A new nasal rasp has been developed from tungsten-carbide steel and is available in eight different cutting grits.
(16) The rasp appears to be the safest and most effective method to gain vascularity for healing of meniscus repairs.
(17) "Cannes has always been a useful idiot for Hollywood," explains Toback, rasping down the line from his apartment in New York.
(18) Log survivorship curves of interval data from both intact animals and isolated CNS indicate that the pattern of motor output is controlled by at least two processes, one generating intervals between rasps within a bout, and the other generating intervals between bouts of rasping.
(19) SEM shows certain basic features such as spines in the oral sucker and the acetabulum which may facilitate rasping and attachment of the parasite to stay in the bloodstream of the definitive host.
(20) Standup Terry Alderton argued aloud with his demonic subconscious; Nick Helm 's rasping fury barely concealed a need to be loved; Cariad Lloyd had great fun seeking a father figure in the front row.