(n.) A pawl, click, or detent, for holding or propelling a ratchet wheel, or ratch, etc.
(n.) A mechanism composed of a ratchet wheel, or ratch, and pawl. See Ratchet wheel, below, and 2d Ratch.
Example Sentences:
(1) But similar accusations have been levelled by Anders Fogh Rasmussen , the secretary general of Nato, and by pro-shale officials in Romania and Lithuania , as cold war-style tensions have ratcheted.
(2) President Obama is to meet today with members of the National Governors Association – a prime opportunity for the president to ratchet up the pressure on Republicans to make a deal.
(3) Muller's ratchet is an important concept in population genetics.
(4) The prolonged estrogen requirement during the lag period is not truly discontinuous as previously suggested but rather can be satisfied by discontinuous pulses of estrogen in a ratchet-like fashion because of the stability of their effects.
(5) "There has been a ratcheting down of deterrence gestures by the US, and that has helped cool the situation a little," said John Delury, a North Korea analyst at Yonsei University in Seoul.
(6) Muller's ratchet could have significant implications for variability of disease severity during virus outbreaks, since genetic bottlenecks must often occur during respiratory droplet transmissions and during spread of low-yield RNA viruses from one body site to another (as with human immunodeficiency virus).
(7) North Korea again ratcheted up the tension in its nuclear standoff with the world by declaring yesterday that it would "weaponise" all of its plutonium and threatening its opponents with military action.
(8) The effect of this ratcheting motion is to subtract from the DNA molecule's forward movement, at each step, an amount which is proportional to its length.
(9) This sets up a ratchet effect each year and means that pay almost never goes down.
(10) Croatia has bused hundreds of migrants to its border with Hungary, ratcheting up tensions in Europe’s refugee crisis as police fired tear gas to drive back several hundred people trying to enter Slovenia .
(11) Especially because Trump suggested that he never settled cases and derided others who did settle them.” The looming move to the White House ratcheted up pressure, Tobias said.
(12) Once these kick in in earnest, they will sweep many species out of their habitability zones, and ratchet up the extinction rate still further.
(13) Speaking soon afterwards, Tony Blair said it was time to "ratchet up the international and diplomatic pressure" on Iran and demonstrate Tehran's "total isolation" on the issue.
(14) It would drive precious talent abroad and would be used by those in other banks to ratchet up their own salaries.
(15) Their voices will act like a ratchet, driving up ambition on climate.
(16) The report warned that the five-year program of cuts imposed by the Abbott government started gently but would “ratchet sharply upwards” in coming years.
(17) Ratcheting up the pressure ahead of tomorrow's Summit in Brussels, Hollande also said he would fight German attempts to create a federalised eurozone.
(18) The tension ratcheted up when the team decamped to Paris before the show, especially when American Vogue editor Anna Wintour swung by to cast her eye over the work.
(19) The Israeli government is reportedly fearful that any guidelines agreed in Paris would be turned into another UN resolution before Trump’s inauguration, and it has ratcheted up its rhetoric, presenting itself as the victim of an international conspiracy.
(20) On Tuesday, president Bashar al-Assad ratcheted up his own language by describing the crisis as "a real war" and pledged to do everything necessary to prevail.
Regulation
Definition:
(n.) The act of regulating, or the state of being regulated.
(n.) A rule or order prescribed for management or government; prescription; a regulating principle; a governing direction; precept; law; as, the regulations of a society or a school.
Example Sentences:
(1) Isotope competition studies indicated that the pathway was regulated by isoleucine.
(2) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(3) Cellulase regulation appears to depend upon a complex relationship involving catabolite repression, inhibition, and induction.
(4) Each process has been linked to the regulation of cholesterol accretion in the arterial cell.
(5) Down and up regulation by peptides may be useful for treatment of cough and prevention of aspiration pneumonia.
(6) Comparison of wild type and the mutant parD promoter sequences indicated that three short repeats are likely involved in the negative regulation of this promoter.
(7) The vascular endothelium is capable of regulating tissue perfusion by the release of endothelium-derived relaxing factor to modulate vasomotor tone of the resistance vasculature.
(8) To examine the central nervous system regulation of duodenal bicarbonate secretion, an animal model was developed that allowed cerebroventricular and intravenous injections as well as collection of duodenal perfusates in awake, freely moving rats.
(9) The observed relationship between prorenin and renin substrate concentrations might be a consequence of their regulation by common factors.
(10) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(11) This study was designed to investigate the localization and cyclic regulation of the mRNA for these two IGFBPs in the porcine ovary, RNA was extracted from whole ovaries morphologically classified as immature, preovulatory, and luteal.
(12) At the same time the duodenum can be isolated from the stomach and maintained under constant stimulus by a continual infusion at regulated pressure, volume and temperature into the distal cannula.
(13) The effects of glucagon-induced insulin secretion upon this lipid regulation are discussed that may resolve conflicting reports in the literature are resolved.
(14) In this phase the educational practices are vastly determined by individual activities which form the basis for later regulations by the state.
(15) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(16) The results suggest differential regulation of IL-6 expression between fibroblasts and macrophages.
(17) This paper has considered the effects and potential application of PFCs, their emulsions and emulsion components for regulating growth and metabolic functions of microbial, animal and plant cells in culture.
(18) These data indicate that CSF levels are not inversely related to the blood neutrophil count in chronic idiopathic neutropenia and suggest that CSF is not a hormone regulating the blood neutrophil count in a manner analogous to the erythropoietin regulation of circulating erythrocyte levels.
(19) Comprehensive regulations are being developed to limit human exposure to contamination in drinking water by the United States Environmental Protection Agency (EPA) under the authority of the Safe Drinking Water Act (SDWA).
(20) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.