(v. t.) To place again; to restore to a former place, position, condition, or the like.
(v. t.) To refund; to repay; to restore; as, to replace a sum of money borrowed.
(v. t.) To supply or substitute an equivalent for; as, to replace a lost document.
(v. t.) To take the place of; to supply the want of; to fulfull the end or office of.
(v. t.) To put in a new or different place.
Example Sentences:
(1) Thyroid replacement led to resolution of both apnea and depression.
(2) This may be due to efficient replacement of Leu by Phe at CUC (and, probably, CUU) codons throughout the genome.
(3) The previous year, he claimed £1,415 for two new sofas, made two separate claims of £230 and £108 for new bed linen, charged £86 for a new kettle and kitchen utensils and made two separate claims, of £65 and £186, for replacement glasses and crockery.
(4) We recently demonstrated that functional change in SSI was possible simply by replacing the amino acid residue at the reactive P1 site (methionine 73) of SSI.
(5) Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11 residue is replaced by glutamate gamma-alkylesters.
(6) In fact, the addition of conditioned medium obtained by 48 hr preincubation of isolated monocytes with 10% PF-382 supernatant (M-CM2) or the concomitant addition of supernatant from PF-382 cells (PF-382-CM) and from unstimulated monocytes (M-CM1) are capable of fully replacing the presence of monocytes in the BFU-E assay.
(7) Major plasma metabolites of quazepam were 2-oxoquazepam (OQ), obtained by replacement of S by O,N-desalkyl-2-oxoquazepam (DOQ), and 3-hydroxy-2-oxoquazepam (HOQ) glucuronide.
(8) Attachment of the graft to the wound is similar with and without the addition of human basic fibroblast growth factor, a potent angiogenic agent, to the skin replacement before graft placement on wounds.
(9) It was concluded that the detachment of the oxaloyl residue from oxaloacetate and its replacement by a proton proceed with inversion of configuration at the methylene group which becomes methyl during the hydrolysis.
(10) I f you haven’t got a family, you need that replaced in some way, that’s the most important thing you can do for someone in care,” says 24-year-old Chloe Juliette, herself a care leaver.
(11) It is an intriguing moment: the new culture secretary, Sajid Javid, who was brought in to replace Maria Miller last month, is something of an unknown quantity.
(12) Replacement of Na+ by K+ or Li+ did not alter uptake, whereas replacement of Cl- by HCO-3 or gluconate- reduced uptake by approximately 40%.
(13) He underwent a mitral and aortic valve replacement, followed by a complicated postoperative course.
(14) Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N-methyl-D-glucamine HCl.
(15) C. parasitica mutant strains deficient in the production of endothiapepsin (eapA-) were constructed using a gene-replacement strategy.
(16) Replacement of vinyl groups with bulkier substituents (hydroxyethyl or acetyl groups) decreases holoenzyme stability and catalytic activity.
(17) It became fully operational in 1975, replacing its predecessor the rubber bullet.
(18) The experimental results for protein preparations of calmodulin in which Ca2+ was isomorphically replaced by Tb3+ were obtained by a spectrometer working at the Institute of Nuclear Physics.
(19) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(20) Ultrastructural study of the uterine lesion demonstrated smooth muscle cells with only a few "autophagic" facuoles to cells nearly replaced by lysosomes.
Substitute
Definition:
(n.) One who, or that which, is substituted or put in the place of another; one who acts for another; that which stands in lieu of something else
(n.) a person who enlists for military service in the place of a conscript or drafted man.
(n.) To put in the place of another person or thing; to exchange.
Example Sentences:
(1) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(2) In the clinical trials in which there was complete substitution of fat-modified ruminant foods for conventional ruminant products the fall in serum cholesterol was approximately 10%.
(3) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(4) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(5) The resonance Raman spectra of oxy and deoxy cobalt-substituted hemoglobin (CoHb) are reported.
(6) The most important conclusion of both conferences was that oestrogen substitution can significantly reduce the incidence of fractures in postmenopausal women.
(7) S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine.
(8) This implies that the epitope(s) of NNA-PLA2 might comprise some substituted residues in the sequence of PLA2 homologues.
(9) The deletions and substitutions appear to occur in separate molecules.
(10) Combination of domain substitutions to generate the [Glu107,123]bFGF and [Arg19,Lys123,126]bFGF mutants did not show any additivity of the mutations on biological activity.
(11) N-Methoxysulphonamides showed no inhibitory activity, as predicted by the classic work of Krebs on N-substituted inhibitors.
(12) Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N-methyl-D-glucamine HCl.
(13) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(14) Substitutes: Andoni Zubizarreta (Spain), Lajos Detari (Hungary), Dragan Stojkovic (Yugoslavia), Igor Belanov (USSR), Preben Elkjær Larsen (Denmark), Lars Larsson (Sweden), Alexandre Zavarov (USSR).
(15) Lipoprotein concentrations reverted to normal after substitution with thyroxine (T4) until the euthyroid state was reached.
(16) Taken together with our previous studies showing that MDMA substitutes for the phenylisopropylamine stimulant (+)amphetamine, but that neither MDE nor N-OH MDA substitute for (+)amphetamine or for the phenylisopropylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), the present results [i.e., MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine] suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N-OH MDA are MDMA-like agents with even less of an amphetamine-like component of action than MDMA itself.
(17) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
(18) Substitution of DnaK protein with that of the mutant DnaK756 protein blocks lambda P release.
(19) To selectively stain polyanionic macromolecules of growth plate cartilage and to prevent artifacts induced by aqueous fixation, proximal tibial growth plates were excised from rats, slam-frozen, and freeze-substituted in 100% methanol containing the cationic dye Alcian blue.
(20) Plasma drug concentrations, subjective self-ratings, and the digit symbol substitution test (DSST) were evaluated during 24 hours after dosage.