(n. pl.) A disease which affects children, and which is characterized by a bulky head, crooked spine and limbs, depressed ribs, enlarged and spongy articular epiphyses, tumid abdomen, and short stature, together with clear and often premature mental faculties. The essential cause of the disease appears to be the nondeposition of earthy salts in the osteoid tissues. Children afflicted with this malady stand and walk unsteadily. Called also rachitis.
Example Sentences:
(1) A survey carried out two and three years after the launch of the official campaign also showed a reduction in the prevalence of rickets in children taking low dose supplements equivalent to about 2.5 micrograms (100 IU) vitamin D daily.
(2) Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.
(3) Where UV radiation is restricted, individual propensity to rickets within a given Asian community is mainly determined by dietary factors.
(4) In a large commercial goat farm rickets-like symptoms were diagnosed in goat kids.
(5) One of the metabolites proved to be as active as the parent vitamin in curing rickets and was found in large amounts in liver, blood, and bone.
(6) The influence of extra phosphorus (P) and calcium (Ca) on the incidence of rickets was studied in 40 infants with a birthweight below 1.5 kg.
(7) The healing of rickets, the stimulation of intestinal Ca and P transport, the effect on bone mineral, and the induction of renal calcifications have been examined.
(8) It has been confirmed that the foetal parathyroid glands are important in development and that thyroparathyroidectomy (TXPTX) of the ovine foetus with thyroxine (T4) replacement leads to hypocalcaemia, retarded skeletal development, depressed calcification and rickets, relative to thyroidectomy plus T4 replacement.
(9) A boy with Lowe syndrome who manifested renal Fanconi syndrome by severe hypophosphatemic rickets, failure to thrive, and metabolic acidosis failed to improve with conventional bolus therapy of phosphate and bicarbonate.
(10) Some of the factors predisposing to rickets were assessed in the rachitic children and in age-matched controls.
(11) Vitamin D deficiency contributes to bone demineralization and rickets.
(12) Lymphocyte cell lines were established from five patients with vitamin D-dependent rickets, type II (VDDR-II).
(13) Clinical signs of rickets are still absent at this time, while an increased activity of the serum alkaline phosphatase signals the beginning of the illness.
(14) The majority of this thickening was due to an increase in the zone of proliferation, identical to that which occurs in calcium-deficiency rickets.
(15) A 22-month-old girl with cystinotic rickets was given 1 microgram 1,25-dihydroxycholecalciferol (1,25-DHCC) daily in addition to standard treatment.
(16) The patients were divided into 5 groups, 1) Osteomalacia and rickets 42 cases, showing typical changes of bone in X-ray films.
(17) In addition, the improved growth and healing of rickets further attest to the efficacy of the new treatment.
(18) In contrast, it appears that doses of either drug that are curative in D deficiency rickets are only partly active in PDR.
(19) During the latter half of an infant's first year, adequate mineral and vitamin D intakes may be important not only for the prevention of rickets but also for the attainment of optimal adult peak bone mass.
(20) Renal tubular dysfunctions with secondary rickets may be lacking altogether, even in chronic patients.