(1) The alpha T3-1 cell line which was derived by targeted tumorigenesis in transgenic mice [Windle et al.
(2) Moderate support also was derived for Windle's generalization that maladjustment scores decrease on retest.
(3) The agreement between the mathematical model and the experimental data lends credence to the biological model proposed by Windle et al.
(4) In conjunction with previous studies (e.g., Windle and Baxter, 1936; Lyser, 1966), these findings suggest that the circumferential-nonfasciculative and the longitudinal-fasciculative patterns of axonal growth are the two fundamental patterns followed by most early forming axons in the brain stem and spinal cord of all higher vertebrates.
(5) In the last two decades experimental contributions have been accentuated, specially the one conducted by the group of researchers directed by Windle and Guth, who had shown the possibility of regeneration in the central nervous system, as well Lawrende and Kuypers, Brodal, Goldberger and others, which defended the vircarious function as the probable mechanisms of recuperation.