(n.) Having inequalities, small ridges, or points, on the surface; not smooth or plain; as, a rough board; a rough stone; rough cloth.
(n.) Not level; having a broken surface; uneven; -- said of a piece of land, or of a road.
(n.) Not polished; uncut; -- said of a gem; as, a rough diamond.
(n.) Tossed in waves; boisterous; high; -- said of a sea or other piece of water.
(n.) Marked by coarseness; shaggy; ragged; disordered; -- said of dress, appearance, or the like; as, a rough coat.
(n.) Hence, figuratively, lacking refinement, gentleness, or polish.
(n.) Not courteous or kind; harsh; rude; uncivil; as, a rough temper.
(n.) Marked by severity or violence; harsh; hard; as, rough measures or actions.
(n.) Loud and hoarse; offensive to the ear; harsh; grating; -- said of sound, voice, and the like; as, a rough tone; rough numbers.
(n.) Austere; harsh to the taste; as, rough wine.
(n.) Tempestuous; boisterous; stormy; as, rough weather; a rough day.
(n.) Hastily or carelessly done; wanting finish; incomplete; as, a rough estimate; a rough draught.
(n.) Produced offhand.
(n.) Boisterous weather.
(n.) A rude fellow; a coarse bully; a rowdy.
(adv.) In a rough manner; rudely; roughly.
(v. t.) To render rough; to roughen.
(v. t.) To break in, as a horse, especially for military purposes.
(v. t.) To cut or make in a hasty, rough manner; -- with out; as, to rough out a carving, a sketch.
Example Sentences:
(1) By 24 hr, rough endoplasmic reticulum in thecal cells increased from 4.2 to 7% of cell volume, while the amount in granulosa cells increased from less than 3.5% to more than 10%; the quantity remained relatively constant in the theca but declined to prestimulation values in the granulosa layer.
(2) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(3) The cis isomer was retained longer in liver, particularly in mitochondria, but had low retention in that portion of the endoplasmic reticulum isolated as the rough membrane fraction.
(4) The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131.
(5) This heretogeneity occurred mainly as a progressive, decreasing gradient in the first half of this pathway, between the rough endoplasmic reticulum and the mi-cisternae of the Golgi apparatus.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium.
(8) For trials in which the target was present in the array, RT functions were roughly symmetric, the shortest RTs being for extreme distractor ratios, and the longest RTs being for arrays in which there were an equal number of each distractor type.
(9) Classic technics of digital image analysis and new algorithms were used to improve the contrast on the full image or a portion of it, contrast a skin lesion with statistical information deduced from another lesion, evaluate the shape of the lesion, the roughness of the surface, and the transition region from the lesion to the normal skin, and analyze a lesion from the chromatic point of view.
(10) Electron microscopic evaluation of microsomal fractions showed elements of the plasma membrane, including cilia and microvilli, as well as rough and smooth endoplasmic reticulum.
(11) The local guide led us down a rough, uneven pathway, talking as he went.
(12) It's the roughly $2bn in revenue grossed by his blockbuster movies, some of which he had to be talked into making.
(13) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(14) Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively.
(15) The locations of these 15 insertion sites correlate well with the roughly estimated locations of five of the DNase I-hypersensitive subregions.
(16) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
(17) The unique structure we describe is a cytoplasmic organelle which, like annulate lamellae, is closely associated with the endoplasmic reticulum and is presumed to be related to the genesis of rough-surfaced endoplasmic reticulum in tumor cells.
(18) Besides the rough, wrinkled, and brown or black surface of the fingertips, microwrinkles of the epidermis occur on the skin ridges, which have so far not been described.
(19) Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material.
(20) That, roughly, was the theme of the Wednesday Play, Cathy Come Home, (BBC1) directed by Kenneth Loach, produced by Tony Garnett.
Rugged
Definition:
(n.) Full of asperities on the surface; broken into sharp or irregular points, or otherwise uneven; not smooth; rough; as, a rugged mountain; a rugged road.
(n.) Not neat or regular; uneven.
(n.) Rough with bristles or hair; shaggy.
(n.) Harsh; hard; crabbed; austere; -- said of temper, character, and the like, or of persons.
(n.) Stormy; turbulent; tempestuous; rude.
(n.) Rough to the ear; harsh; grating; -- said of sound, style, and the like.
(n.) Sour; surly; frowning; wrinkled; -- said of looks, etc.
(n.) Violent; rude; boisterrous; -- said of conduct, manners, etc.
(n.) Vigorous; robust; hardy; -- said of health, physique, etc.
Example Sentences:
(1) The hosts had resisted through the early stages, emulating their rugged first-half displays against Manchester United and Arsenal here this season, and even mustered a flurry of half-chances just before the interval to offer a reminder they might glean greater reward thereafter.
(2) Steps wind down a rugged rock face to a bedroom, while light floods in from round skylights in the domed ceiling above.
(3) The Turner prize-winning artist has turned his sights on the survivalist and his exceptionally rugged version of masculinity, arguing that it isn’t fit for the 21st century.
(4) Many survivors use it to get the accommodations needed to stay in school, while others used it to hold their institutions accountable for sweeping sexual assault under the rug.” More than two dozen states are suing the Obama administration over its guidance on transgender students in an effort that is overwhelmingly led by Republican secretaries of state.
(5) As the president of Russia's Kalmykia republic from 1993 to 2010, Ilyumzhinov undoubtedly has close ties to the Kremlin, and a woven rug featuring Putin's face hangs in his office.
(6) Also, a wildfire in a rugged area near the Canadian border chased hundreds of people from their homes and burned 10 to 12 structures, and a blaze north-east of Colville scorched almost five square miles and forced evacuations at campgrounds in the area.
(7) Allergenic proteins were extracted from one silk batch that was imported to be used as filling material for bed mattresses and rugs.
(8) And reporting by the Observer reveals the extent to which al-Qaida has integrated itself with powerful tribes that control large swaths of Yemen's rugged east and parts of its south.
(9) FIVE MORE FRENCH COASTAL GEMS Marseille grotto Facebook Twitter Pinterest Photograph: Alamy A 40-minute walk from Marseille’s Luminy university campus, Calanque de Sugiton, the most picturesque of the city’s rugged, limestone coves has blue-green waters, twisted pine trees and a narrow island-rock to swim out to known as Le Torpilleur.
(10) Laminin and its E1-4 and E8 fragments are able to activate the ecto-5'-nucleotidase activity of both BCS-TC2 and Rugli cells.
(11) Pictures of the young Depardieu in a good light suggest a rugged, brooding, if not classically good-looking man with a squared chin and mop of blonde hair.
(12) In the presence of glucose oxidase and trien this polymer forms rugged, cross-linked, electroactive films on the surface of electrodes, thereby eliminating the requirement for a membrane for containing the enzyme and redox couple.
(13) The tone was set in the second minute when Ben Westwood, Warrington's notoriously rugged forward, left the Wigan stand-off Blake Green on the ground needing lengthy treatment.
(14) The simple design and rugged construction permit the incorporation of the apparatus into many manual or personal computer controlled oxygen consumption systems.
(15) Both offer lodges and campsites, but keep in mind that only a very small fraction of these remote and rugged parks are accessible by road.
(16) "When a similar report was released in 2009, the Administration largely swept it under the rug.
(17) La Posada has undergone a $12m renovation, transforming it into a magical place with handmade Mexican tin and tile mirrors, six-foot cast iron tubs, hand woven Zapotec rugs, and hand-painted furniture and tile murals.
(18) These assays have proven to be accurate, precise, reproducible, and rugged during clinical sample analyses.
(19) And cutting support now would take demand out of the economy, pull the rug from under the recovery, and delay our return to sustained growth.
(20) Chelsea had laboured at times without him in that first period, Begovic denying them reward from an urgent opening and Stoke rugged and organised until self-destructing with half-time in sight.