(n.) Having inequalities, small ridges, or points, on the surface; not smooth or plain; as, a rough board; a rough stone; rough cloth.
(n.) Not level; having a broken surface; uneven; -- said of a piece of land, or of a road.
(n.) Not polished; uncut; -- said of a gem; as, a rough diamond.
(n.) Tossed in waves; boisterous; high; -- said of a sea or other piece of water.
(n.) Marked by coarseness; shaggy; ragged; disordered; -- said of dress, appearance, or the like; as, a rough coat.
(n.) Hence, figuratively, lacking refinement, gentleness, or polish.
(n.) Not courteous or kind; harsh; rude; uncivil; as, a rough temper.
(n.) Marked by severity or violence; harsh; hard; as, rough measures or actions.
(n.) Loud and hoarse; offensive to the ear; harsh; grating; -- said of sound, voice, and the like; as, a rough tone; rough numbers.
(n.) Austere; harsh to the taste; as, rough wine.
(n.) Tempestuous; boisterous; stormy; as, rough weather; a rough day.
(n.) Hastily or carelessly done; wanting finish; incomplete; as, a rough estimate; a rough draught.
(n.) Produced offhand.
(n.) Boisterous weather.
(n.) A rude fellow; a coarse bully; a rowdy.
(adv.) In a rough manner; rudely; roughly.
(v. t.) To render rough; to roughen.
(v. t.) To break in, as a horse, especially for military purposes.
(v. t.) To cut or make in a hasty, rough manner; -- with out; as, to rough out a carving, a sketch.
Example Sentences:
(1) By 24 hr, rough endoplasmic reticulum in thecal cells increased from 4.2 to 7% of cell volume, while the amount in granulosa cells increased from less than 3.5% to more than 10%; the quantity remained relatively constant in the theca but declined to prestimulation values in the granulosa layer.
(2) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(3) The cis isomer was retained longer in liver, particularly in mitochondria, but had low retention in that portion of the endoplasmic reticulum isolated as the rough membrane fraction.
(4) The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131.
(5) This heretogeneity occurred mainly as a progressive, decreasing gradient in the first half of this pathway, between the rough endoplasmic reticulum and the mi-cisternae of the Golgi apparatus.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium.
(8) For trials in which the target was present in the array, RT functions were roughly symmetric, the shortest RTs being for extreme distractor ratios, and the longest RTs being for arrays in which there were an equal number of each distractor type.
(9) Classic technics of digital image analysis and new algorithms were used to improve the contrast on the full image or a portion of it, contrast a skin lesion with statistical information deduced from another lesion, evaluate the shape of the lesion, the roughness of the surface, and the transition region from the lesion to the normal skin, and analyze a lesion from the chromatic point of view.
(10) Electron microscopic evaluation of microsomal fractions showed elements of the plasma membrane, including cilia and microvilli, as well as rough and smooth endoplasmic reticulum.
(11) The local guide led us down a rough, uneven pathway, talking as he went.
(12) It's the roughly $2bn in revenue grossed by his blockbuster movies, some of which he had to be talked into making.
(13) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(14) Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively.
(15) The locations of these 15 insertion sites correlate well with the roughly estimated locations of five of the DNase I-hypersensitive subregions.
(16) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
(17) The unique structure we describe is a cytoplasmic organelle which, like annulate lamellae, is closely associated with the endoplasmic reticulum and is presumed to be related to the genesis of rough-surfaced endoplasmic reticulum in tumor cells.
(18) Besides the rough, wrinkled, and brown or black surface of the fingertips, microwrinkles of the epidermis occur on the skin ridges, which have so far not been described.
(19) Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material.
(20) That, roughly, was the theme of the Wednesday Play, Cathy Come Home, (BBC1) directed by Kenneth Loach, produced by Tony Garnett.
Soft
Definition:
(superl.) Easily yielding to pressure; easily impressed, molded, or cut; not firm in resisting; impressible; yielding; also, malleable; -- opposed to hard; as, a soft bed; a soft peach; soft earth; soft wood or metal.
(superl.) Not rough, rugged, or harsh to the touch; smooth; delicate; fine; as, soft silk; a soft skin.
(superl.) Hence, agreeable to feel, taste, or inhale; not irritating to the tissues; as, a soft liniment; soft wines.
(superl.) Not harsh or offensive to the sight; not glaring; pleasing to the eye; not exciting by intensity of color or violent contrast; as, soft hues or tints.
(superl.) Not harsh or rough in sound; gentle and pleasing to the ear; flowing; as, soft whispers of music.
(superl.) Easily yielding; susceptible to influence; flexible; gentle; kind.
(superl.) Expressing gentleness, tenderness, or the like; mild; conciliatory; courteous; kind; as, soft eyes.
(superl.) Effeminate; not courageous or manly, weak.
(superl.) Having, or consisting of, a gentle curve or curves; not angular or abrupt; as, soft outlines.
(superl.) Not tinged with mineral salts; adapted to decompose soap; as, soft water is the best for washing.
(superl.) Applied to a palatal, a sibilant, or a dental consonant (as g in gem, c in cent, etc.) as distinguished from a guttural mute (as g in go, c in cone, etc.); -- opposed to hard.
(superl.) Belonging to the class of sonant elements as distinguished from the surd, and considered as involving less force in utterance; as, b, d, g, z, v, etc., in contrast with p, t, k, s, f, etc.
(n.) A soft or foolish person; an idiot.
(adv.) Softly; without roughness or harshness; gently; quietly.
(interj.) Be quiet; hold; stop; not so fast.
Example Sentences:
(1) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(2) Bilateral symmetric soft-tissue masses posterior to the glandular tissue with accompanying calcifications should suggest the diagnosis.
(3) None of the other soft tissue layers-ameloblasts, stratum intermedium or dental follicle--immunostain for TGF-beta 1.
(4) The cotransfected cells do not grow in soft agar, but show enhanced soft agar growth relative to controls in the presence of added aFGF and heparin.
(5) It was hypothesized that compensatory restraining influences of surrounding soft tissues prevented a more severe facial malformation from occurring.
(6) After the diagnosis of a soft-tissue injury (sprain, strain, or contusion) has been made, treatment must include an initial 24- to 48-hour period of RICE.
(7) It is a specific clinical picture with extensive soft tissue gas and swelling of the forearm.
(8) Benign and malignant epithelial and soft tissue tumors of the skin were usually negatively stained with MoAb HMSA-2.
(9) The patient, a 12 year-old boy, showed a soft white yellowish mycotic excrescence with clear borders which had followed the introduction of a small piece of straw into the cornea.
(10) In open fractures especially in those with severe soft tissue damage, fracture stabilisation is best achieved by using external fixators.
(11) A distally based posterior tibial artery adipofascial flap with skin graft was used for the reconstruction of soft tissue defects over the Achilles tendon in three cases and over the heel in three cases.
(12) The third patient was using an extended-wear soft contact lens for correction of residual myopia.
(13) Computed tomography (CT) is the most sensitive radiologic study for detecting these tumors, which usually are small, round, sharply marginated, and of homogeneous soft tissue density.
(14) The latter indicated that, despite the smaller size of the digital image, they were adequate for resolving clinically significant soft-tissue densities.
(15) We isolated soft agar colonies (a-subclones) and sub-clones from foci (h-subclones) of both hybrids, and, as a control, subclones of cells from random areas without foci of one hybrid (BS181 p-subclones).
(16) Three of the tumours represented primary soft tissue lesions, while locally recurrent tumour or pulmonary metastases were studied from the 4 skeletal tumours, all of which had been diagnosed previously as Ewing's sarcomas.
(17) The technique is based on a multiple regression analysis of the renal curves and separate heart and soft tissue curves which together represent background activity.
(18) A hospital-based case-control study on soft tissue sarcomas (STS) was conducted in 1983-84 in Torino and in Padova (Italy).
(19) This phenomenon can have a special significance for defining the vitality in inflammation of bone tissue, in burns and in necrosis of soft tissues a.a. of the Achilles tendon.
(20) Thirty patients required a second operation to an area previously addressed reflecting inadequacies in technique, the unpredictability of bone grafts, and soft-tissue scarring.