(n.) Having inequalities, small ridges, or points, on the surface; not smooth or plain; as, a rough board; a rough stone; rough cloth.
(n.) Not level; having a broken surface; uneven; -- said of a piece of land, or of a road.
(n.) Not polished; uncut; -- said of a gem; as, a rough diamond.
(n.) Tossed in waves; boisterous; high; -- said of a sea or other piece of water.
(n.) Marked by coarseness; shaggy; ragged; disordered; -- said of dress, appearance, or the like; as, a rough coat.
(n.) Hence, figuratively, lacking refinement, gentleness, or polish.
(n.) Not courteous or kind; harsh; rude; uncivil; as, a rough temper.
(n.) Marked by severity or violence; harsh; hard; as, rough measures or actions.
(n.) Loud and hoarse; offensive to the ear; harsh; grating; -- said of sound, voice, and the like; as, a rough tone; rough numbers.
(n.) Austere; harsh to the taste; as, rough wine.
(n.) Tempestuous; boisterous; stormy; as, rough weather; a rough day.
(n.) Hastily or carelessly done; wanting finish; incomplete; as, a rough estimate; a rough draught.
(n.) Produced offhand.
(n.) Boisterous weather.
(n.) A rude fellow; a coarse bully; a rowdy.
(adv.) In a rough manner; rudely; roughly.
(v. t.) To render rough; to roughen.
(v. t.) To break in, as a horse, especially for military purposes.
(v. t.) To cut or make in a hasty, rough manner; -- with out; as, to rough out a carving, a sketch.
Example Sentences:
(1) By 24 hr, rough endoplasmic reticulum in thecal cells increased from 4.2 to 7% of cell volume, while the amount in granulosa cells increased from less than 3.5% to more than 10%; the quantity remained relatively constant in the theca but declined to prestimulation values in the granulosa layer.
(2) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(3) The cis isomer was retained longer in liver, particularly in mitochondria, but had low retention in that portion of the endoplasmic reticulum isolated as the rough membrane fraction.
(4) The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131.
(5) This heretogeneity occurred mainly as a progressive, decreasing gradient in the first half of this pathway, between the rough endoplasmic reticulum and the mi-cisternae of the Golgi apparatus.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium.
(8) For trials in which the target was present in the array, RT functions were roughly symmetric, the shortest RTs being for extreme distractor ratios, and the longest RTs being for arrays in which there were an equal number of each distractor type.
(9) Classic technics of digital image analysis and new algorithms were used to improve the contrast on the full image or a portion of it, contrast a skin lesion with statistical information deduced from another lesion, evaluate the shape of the lesion, the roughness of the surface, and the transition region from the lesion to the normal skin, and analyze a lesion from the chromatic point of view.
(10) Electron microscopic evaluation of microsomal fractions showed elements of the plasma membrane, including cilia and microvilli, as well as rough and smooth endoplasmic reticulum.
(11) The local guide led us down a rough, uneven pathway, talking as he went.
(12) It's the roughly $2bn in revenue grossed by his blockbuster movies, some of which he had to be talked into making.
(13) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(14) Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively.
(15) The locations of these 15 insertion sites correlate well with the roughly estimated locations of five of the DNase I-hypersensitive subregions.
(16) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
(17) The unique structure we describe is a cytoplasmic organelle which, like annulate lamellae, is closely associated with the endoplasmic reticulum and is presumed to be related to the genesis of rough-surfaced endoplasmic reticulum in tumor cells.
(18) Besides the rough, wrinkled, and brown or black surface of the fingertips, microwrinkles of the epidermis occur on the skin ridges, which have so far not been described.
(19) Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material.
(20) That, roughly, was the theme of the Wednesday Play, Cathy Come Home, (BBC1) directed by Kenneth Loach, produced by Tony Garnett.
Tender
Definition:
(n.) One who tends; one who takes care of any person or thing; a nurse.
(n.) A vessel employed to attend other vessels, to supply them with provisions and other stores, to convey intelligence, or the like.
(n.) A car attached to a locomotive, for carrying a supply of fuel and water.
(v. t.) To offer in payment or satisfaction of a demand, in order to save a penalty or forfeiture; as, to tender the amount of rent or debt.
(v. t.) To offer in words; to present for acceptance.
(n.) An offer, either of money to pay a debt, or of service to be performed, in order to save a penalty or forfeiture, which would be incurred by nonpayment or nonperformance; as, the tender of rent due, or of the amount of a note, with interest.
(n.) Any offer or proposal made for acceptance; as, a tender of a loan, of service, or of friendship; a tender of a bid for a contract.
(n.) The thing offered; especially, money offered in payment of an obligation.
(superl.) Easily impressed, broken, bruised, or injured; not firm or hard; delicate; as, tender plants; tender flesh; tender fruit.
(superl.) Sensible to impression and pain; easily pained.
(superl.) Physically weak; not hardly or able to endure hardship; immature; effeminate.
(superl.) Susceptible of the softer passions, as love, compassion, kindness; compassionate; pitiful; anxious for another's good; easily excited to pity, forgiveness, or favor; sympathetic.
(superl.) Exciting kind concern; dear; precious.
(superl.) Careful to save inviolate, or not to injure; -- with of.
(superl.) Unwilling to cause pain; gentle; mild.
(superl.) Adapted to excite feeling or sympathy; expressive of the softer passions; pathetic; as, tender expressions; tender expostulations; a tender strain.
(superl.) Apt to give pain; causing grief or pain; delicate; as, a tender subject.
(superl.) Heeling over too easily when under sail; -- said of a vessel.
(n.) Regard; care; kind concern.
(v. t.) To have a care of; to be tender toward; hence, to regard; to esteem; to value.
Example Sentences:
(1) Gross deformity, point tenderness and decrease in supination and pronation movements of the forearm were the best predictors of bony injury.
(2) The degree of discomfort was slightly greater in women who complained of breast tenderness within three days prior to the mammogram but was not strongly related to age, menstrual status, or week of the menstrual cycle.
(3) Xu, the ABP chairman, disputed any claims of impropriety, and said his company went through a “robust and thorough” tender process.
(4) These data suggest that d 7 MFI could be used as a single predictor of d 14 longissimus muscle tenderness; however, CDP inhibitor d 1 activity (a biological event) also may be useful in predicting tenderness.
(5) Eight of 47 LSNs overlying the posterior superior iliac spines (PSIS) were tender.
(6) If LTP is to be effective, thorough coagulation with tender blanching effects is mandatory.
(7) The remaining patients had vague pains, tender abdomen, constitutional symptoms or a mass in the abdomen.
(8) Seventy-nine percent of all subjects were skin-test positive to inhalant allergens, but positive skin tests alone did not correlate with the number of tender points or criteria for fibromyalgia.
(9) Permanent relief of tenderness in the needled structure was obtained for 92 structures; relief for several months in 58; for several weeks in 63; and for several days in 32 out of 288 pain sites followed up.
(10) Three infants presented with acute scrotal swelling, erythema, and a tender irreducible firm mass within the scrotum.
(11) Before and one, two, three, and seven days after the experiment, the following measures were made: (1) superficial masseter and anterior temporalis muscle tenderness (pain threshold), (2) jaw movement (opening and lateral excursion), and (3) current pain level for the right and left sides of the jaw.
(12) Increasing slaughter weight from 60 to 90% was associated with an increase in panel tenderness scores for loin steaks.
(13) Pericranial muscle tenderness and elevated EMG activity may index different aspects of abnormal muscle function.
(14) The results showed significant relief of spontaneous pain, significant reduction in tenderness on pressure and in swelling on days 2, 4 and 6 of the trial, and a significant reduction in functional impairment on days 4 and 6, in the patients who had received the 3% benzydamine cream.
(15) They showed symmetric weakness and tenderness of the proximal muscles, peripheral hypoesthesia and hypo even areflexia.
(16) Lamb leg and rib roasts were more tender when cooked from the thawed state.
(17) In the sensitized state, nociceptors can be activated by low-intensity stimulation; this is probably one of the mechanisms producing deep tenderness.
(18) The abdomen was tender with guarding and a palpable globular mass in the same region.
(19) A 25-year-old man on hemodialysis developed arthritis of 2 right metacarpophalangeal joints and a 65-year-old man on chronic ambulatory peritoneal dialysis suffered from pain and tenderness in the left buttock.
(20) Among 23 patients with daily headache a correlation was found between headache intensity and Total Tenderness Score.