(n.) Having inequalities, small ridges, or points, on the surface; not smooth or plain; as, a rough board; a rough stone; rough cloth.
(n.) Not level; having a broken surface; uneven; -- said of a piece of land, or of a road.
(n.) Not polished; uncut; -- said of a gem; as, a rough diamond.
(n.) Tossed in waves; boisterous; high; -- said of a sea or other piece of water.
(n.) Marked by coarseness; shaggy; ragged; disordered; -- said of dress, appearance, or the like; as, a rough coat.
(n.) Hence, figuratively, lacking refinement, gentleness, or polish.
(n.) Not courteous or kind; harsh; rude; uncivil; as, a rough temper.
(n.) Marked by severity or violence; harsh; hard; as, rough measures or actions.
(n.) Loud and hoarse; offensive to the ear; harsh; grating; -- said of sound, voice, and the like; as, a rough tone; rough numbers.
(n.) Austere; harsh to the taste; as, rough wine.
(n.) Tempestuous; boisterous; stormy; as, rough weather; a rough day.
(n.) Hastily or carelessly done; wanting finish; incomplete; as, a rough estimate; a rough draught.
(n.) Produced offhand.
(n.) Boisterous weather.
(n.) A rude fellow; a coarse bully; a rowdy.
(adv.) In a rough manner; rudely; roughly.
(v. t.) To render rough; to roughen.
(v. t.) To break in, as a horse, especially for military purposes.
(v. t.) To cut or make in a hasty, rough manner; -- with out; as, to rough out a carving, a sketch.
Example Sentences:
(1) By 24 hr, rough endoplasmic reticulum in thecal cells increased from 4.2 to 7% of cell volume, while the amount in granulosa cells increased from less than 3.5% to more than 10%; the quantity remained relatively constant in the theca but declined to prestimulation values in the granulosa layer.
(2) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(3) The cis isomer was retained longer in liver, particularly in mitochondria, but had low retention in that portion of the endoplasmic reticulum isolated as the rough membrane fraction.
(4) The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131.
(5) This heretogeneity occurred mainly as a progressive, decreasing gradient in the first half of this pathway, between the rough endoplasmic reticulum and the mi-cisternae of the Golgi apparatus.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium.
(8) For trials in which the target was present in the array, RT functions were roughly symmetric, the shortest RTs being for extreme distractor ratios, and the longest RTs being for arrays in which there were an equal number of each distractor type.
(9) Classic technics of digital image analysis and new algorithms were used to improve the contrast on the full image or a portion of it, contrast a skin lesion with statistical information deduced from another lesion, evaluate the shape of the lesion, the roughness of the surface, and the transition region from the lesion to the normal skin, and analyze a lesion from the chromatic point of view.
(10) Electron microscopic evaluation of microsomal fractions showed elements of the plasma membrane, including cilia and microvilli, as well as rough and smooth endoplasmic reticulum.
(11) The local guide led us down a rough, uneven pathway, talking as he went.
(12) It's the roughly $2bn in revenue grossed by his blockbuster movies, some of which he had to be talked into making.
(13) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(14) Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively.
(15) The locations of these 15 insertion sites correlate well with the roughly estimated locations of five of the DNase I-hypersensitive subregions.
(16) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
(17) The unique structure we describe is a cytoplasmic organelle which, like annulate lamellae, is closely associated with the endoplasmic reticulum and is presumed to be related to the genesis of rough-surfaced endoplasmic reticulum in tumor cells.
(18) Besides the rough, wrinkled, and brown or black surface of the fingertips, microwrinkles of the epidermis occur on the skin ridges, which have so far not been described.
(19) Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material.
(20) That, roughly, was the theme of the Wednesday Play, Cathy Come Home, (BBC1) directed by Kenneth Loach, produced by Tony Garnett.
Virago
Definition:
(n.) A woman of extraordinary stature, strength, and courage; a woman who has the robust body and masculine mind of a man; a female warrior.
(n.) Hence, a mannish woman; a bold, turbulent woman; a termagant; a vixen.
Example Sentences:
(1) The publisher's first move into the UK market came in 1987 with the acquisition of Chatto, Virago, Bodley Head and Jonathan Cape, and later with the purchase of Century Hutchinson and the trade division of Reed Books.
(2) And if not everyone agrees with her, or approves of Virago, or wants to be published by a women-only imprint, so much the better: "The last thing you want to be is a flat old thing that everybody loves, like a big teddy bear.
(3) According to Lennie Goodings, publisher of Virago, the suggestion that in 1857 "bad girls, smut and perversion were essentially invented in the eyes of the law is both a fascinating story and, crucially, an important way of understanding how we arrived at our ideas of normalcy and deviancy – ideas which are with us to this day".
(4) Thorn's first book – a memoir called Bedsit Disco Queen: How I Grew Up and Tried to Be a Pop Star – will be published by Virago next February.
(5) Goodings, who joined five years later, calls herself "a second-generation Virago" but she was there early enough for it to feel like a start-up: "We were at 5 Wardour Street, five flights up a dusty staircase in one room.
(6) Mad, Bad and Sad: A History of Women and the Mind Doctors from 1800 to the Present is published by Virago Kate Moses Photograph: PR When I think of The Bell Jar , I do not think first of the story of Esther Greenwood's harrowing entrapment in the suffocating air of her own madness.
(7) Sarah Waters's latest book is The Little Stranger, published by Virago
(8) Spare Rib is a brand actually, isn't it, in the sense Virago is a brand?
(9) She recalls one lunch with a literary editor of the Times who "got there and said [she puts on a patrician drawl]: 'I told all the girls in the office I'm going out with a Virago today!'
(10) It was Taylor's ability to get into the skin of the character, more than the padding and a tousled salt-and-pepper wig, which transformed the legendary beauty into a blowsy virago.
(11) Virago is 40: A Celebration brings together new writing by authors including Margaret Atwood and Sarah Waters , on the subject of 40.
(12) It's only slowly, and in recent years, that the voice of the mother has come out – the odd middlebrow novel of the kind Virago and Persephone rescue ( EM Delafield or Dorothy Whipple ) and more recently Margaret Drabble , Julie Myerson , Rachel Cusk .
(13) The Haunting of Sylvia Plath by Jacqueline Rose is published by Virago Lionel Shriver Photograph: Rolph Gobits I read The Bell Jar as an adolescent, and like most teenagers had no problem identifying with a young woman who had everything going for her – looks, talent, opportunity, with her "whole life ahead of her," yadda, yadda, yadda – yet was spiralling into misery.
(14) Virago has made a profit every year since it was set up ("a healthy profit", Goodings adds, though she won't say how much on an annual turnover that averages around £3.5m), and she is proud of this.
(15) This is, I fully admit, a pretty odd kind of nostalgia, and the person I blame for it mostly is Katharine Whitehorn, whose Cooking in a Bedsitter, first published in 1961, in print and regularly updated for the next 40 years, and now triumphantly reissued in all its original greasy and hardscrabble glory by Virago (I just wish they had made the cover wipe-clean), fuelled it for many years.
(16) Few insiders feel News Corp was a serious contender to take over Penguin, as reported at the weekend, but Hachette, which has Little, Brown and Virago under its wing, is rumoured to be in buying mood and unlikely to settle for a place in the second division.
(17) Like Spare Rib, Virago referenced the Garden of Eden with a logo of an apple with a chunk bitten out of it: tree of knowledge, here we come.
(18) Virago is 40: A Celebration is available as a free ebook at virago.co.uk
(19) "I'm not going to feel defensive about Virago until the Today programme changes," she says, referring to the fact that just 18% of contributors to the flagship news show are female.
(20) Prized novelists include Waters and Sarah Dunant – authors of Virago's two top‑selling titles last year – and Marilynne Robinson, who won the Orange prize for Home in 2009, a moment Goodings cites as a career highlight.