(adv.) In a rough manner; unevenly; harshly; rudely; severely; austerely.
Example Sentences:
(1) By 24 hr, rough endoplasmic reticulum in thecal cells increased from 4.2 to 7% of cell volume, while the amount in granulosa cells increased from less than 3.5% to more than 10%; the quantity remained relatively constant in the theca but declined to prestimulation values in the granulosa layer.
(2) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(3) The cis isomer was retained longer in liver, particularly in mitochondria, but had low retention in that portion of the endoplasmic reticulum isolated as the rough membrane fraction.
(4) The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131.
(5) This heretogeneity occurred mainly as a progressive, decreasing gradient in the first half of this pathway, between the rough endoplasmic reticulum and the mi-cisternae of the Golgi apparatus.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium.
(8) For trials in which the target was present in the array, RT functions were roughly symmetric, the shortest RTs being for extreme distractor ratios, and the longest RTs being for arrays in which there were an equal number of each distractor type.
(9) Classic technics of digital image analysis and new algorithms were used to improve the contrast on the full image or a portion of it, contrast a skin lesion with statistical information deduced from another lesion, evaluate the shape of the lesion, the roughness of the surface, and the transition region from the lesion to the normal skin, and analyze a lesion from the chromatic point of view.
(10) Electron microscopic evaluation of microsomal fractions showed elements of the plasma membrane, including cilia and microvilli, as well as rough and smooth endoplasmic reticulum.
(11) The local guide led us down a rough, uneven pathway, talking as he went.
(12) It's the roughly $2bn in revenue grossed by his blockbuster movies, some of which he had to be talked into making.
(13) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(14) Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively.
(15) The locations of these 15 insertion sites correlate well with the roughly estimated locations of five of the DNase I-hypersensitive subregions.
(16) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
(17) The unique structure we describe is a cytoplasmic organelle which, like annulate lamellae, is closely associated with the endoplasmic reticulum and is presumed to be related to the genesis of rough-surfaced endoplasmic reticulum in tumor cells.
(18) Besides the rough, wrinkled, and brown or black surface of the fingertips, microwrinkles of the epidermis occur on the skin ridges, which have so far not been described.
(19) Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material.
(20) That, roughly, was the theme of the Wednesday Play, Cathy Come Home, (BBC1) directed by Kenneth Loach, produced by Tony Garnett.
Toughly
Definition:
(adv.) In a tough manner.
Example Sentences:
(1) Photograph: Guardian The research also compiled data covered by a wider definition of tax haven, including onshore jurisdictions such as the US state of Delaware – accused by the Cayman islands of playing "faster and looser" even than offshore jurisdictions – and the Republic of Ireland, which has come under sustained pressure from other EU states to reform its own low-tax, light-tough, regulatory environment.
(2) Nick Robins, head of the Climate Change Centre at HSBC, said: "If you think about low-carbon energy only in terms of carbon, then things look tough [in terms of not using coal].
(3) A series of hierarchical multiple regressions revealed the effects of Surgency, Agreeableness, Conscientiousness, Emotional Stability, and Intellect on evoking upset in spouses through condescension (e.g., treating spouse as stupid or inferior), possessiveness (demanding too much time and attention), abuse (slapping spouse), unfaithfulness (having sex with others), inconsiderateness (leaving toilet seat up), moodiness (crying a lot), alcohol abuse (drinking too much alcohol), emotional constriction (hiding emotions to act tough), and self-centeredness (acting selfishly).
(4) A lfred Ekpenyong knows first hand how tough it can be to find a secure foothold in mainstream society after leaving prison.
(5) The texture of a food item can be distinguished in hardness, toughness, stickiness, juiciness and chewability.
(6) Even as the Obama administration moves to deal with some of Guantánamo's most notorious captives, it faces tough challenges to closing the facility.
(7) "It's a tough group but other groups are also tough.
(8) This allowed it to claim that it was becoming more professional, tough minded and responsible.
(9) The austerity programmes administered by western governments in the wake of the 2008 global financial crisis were, of course, intended as a remedy, a tough but necessary course of treatment to relieve the symptoms of debts and deficits and to cure recession.
(10) And he pleased the audience with an acknowledgement that social work is a tough job and social workers only human.
(11) Trade unions have sought to highlight the insecurity of workers who have been forced into self-employment in the tough jobs market of recent years.
(12) UK negotiatiors, though, fought back hard -- thus Cameron's fighting talk in his press conference ( see 12.46pm ) 12.49pm BST Open Europe tweets Cameron's tough talk on the rebate: Open Europe (@OpenEurope) Cameron: in Feb we reached a clear deal rebate would remain unchanged, since then some have tried to question this agreement June 28, 2013 Open Europe (@OpenEurope) Cameron: I defeated these attempts to change the rebate, it will remain unchanged for this long term budget June 28, 2013 12.46pm BST David Cameron press conference underway In Brussels, David Cameron is holding his press conference now.
(13) The mechanical properties of compressed beam specimens of microcrystalline cellulose (Avicel pH 101) have been assessed in terms of the tensile strength (sigma t), Young's modulus (E) and the following fracture mechanics parameters: the critical stress intensity factor (KIC), the critical strain energy release rate (GIC) and the fracture toughness (R).
(14) "2013 was a tough year for us both in minerals and in oil and gas," Cochrane said, adding that the group had relied on"self help", including diversification which offset some of the challenges in its core mining market, improving operational efficiency, and strong growth in its after sales business, where orders were up 16% on 2012 and which accounted for 63% of revenues last year.
(15) "We carved out a few chances, but it was tough to break them down."
(16) Channel 5 will be hoping for a similar return for its new series, although with the launch audience around a third down on last year's opener, it may prove a tough ask.
(17) Dimon, the charismatic leader of the bank, had enjoyed a reputation as a tough, strict taskmaster, the kind of CEO every bank should have.
(18) Cameron put all of his betting chips on what seemed to be the party's trump card: the "vote for us, we're tough on migration and tough on migrants" strategy.
(19) As well as limited terms for MPs, Grillo has called for a referendum on the euro and a tough line on immigration.
(20) "It's a tough game but our best football has come in this competition and we'll try and show it next week.