(1) Moreover, the ribosylation inhibitors converted the glucocorticoid antagonist RU-486 into a potent agonist for cytolysis of L1210 cells.
(2) Decreased levels of receptors for estradiol-17beta, progesterone, and prolactin were found in the tumors remaining after ovariectomy while treatment with the dose (24 mug) of RU 16117, efficient to inhibit tumor growth, has a similar inhibitory effect on the levels of estradiol-17beta and prolactin receptors.
(3) Another two derivatives of RU 486, RU 42848 (didemethyl) and RU 42698 (propargyl), had lower RBA's than RU 486.
(4) Of these two pretreatment alternatives, RU 486 alone has the advantage of a shorter hospital stay.
(5) The in vitro susceptibility of Mycobacterium tuberculosis to a new macrolide antibiotic RU-28965, alone and in combination with rifampicin or isoniazid, was studied by the agar dilution method.
(6) Ru also increased to approximately double its control value.
(7) Raman intensities measured at 815 and 1100 cm-1 in spectra of poly (rI) and poly (rU)-poly (rA)-poly(rU) indicate that the correlation previously established for single- and double-stranded ribopolymer structures is valid also for these multi-stranded structures.
(8) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(9) Renal vascular resistance decreased during RU 486 administration in anesthetized (-25%) and unanesthetized (-19%) rats.
(10) Pretreatment of the lower airways with inhaled atropine did not affect the magnitude of the changes in Ru after inhalation of OA through the nose but significantly attenuated the response of the lower airways.
(11) The direct effect of RU 486 on LH secretion in the absence of exogenous progesterone was evaluated in cells cultured in the absence or presence of 10(-9) M estradiol and then treated for 4 to 24 h with increasing concentrations of RU 486 (10(-12) to 10(-5) M) and stimulated with GnRH (10(-9) M) during the last 3 h of incubation.
(12) Frances' highest administrative court ruled that the French government exceeded its authority in ordering the distribution of RU 497 (mifepristone), but ruled that French abortion law, allowing abortions in the 1st 10 weeks in "situations of distress," did not violate international treaties guaranteeing the "right to life."
(13) Interruption of early pregnancy is a major indication for RU-486.
(14) R units are either occupied (RO) or unoccupied (RU); C units are either active (CA) or inactive (CI).
(15) We report here on developmental changes in [3H]RU 28362 (glucocorticoid receptor) and [3H]aldosterone (mineralocorticoid receptor) binding capacity in soluble fractions prepared from hippocampal tissue.
(16) The antiglucocorticoid activity of the molecule can be demonstrated in humans by a rise in plasma cortisol, ACTH and LPH after RU 486 intake, and by blockade of some peripheral effects of cortisol.
(17) The antiprogesterone RU 486 was utilized to evaluate the possible role of progesterone in ovum maturation, ovulation, fertilization, and embryo cleavage.
(18) The selective D2 dopaminergic antagonists sulpiride (10(-5) M) totally abolished the effect of RU 24926 and partially abolished the effect of lisuride.
(19) The interaction of complexes Ru(bpy)n(TAP)3-n2+ (1a-1d for n = 0-3) with DNA has been investigated using photophysical methods (emission spectroscopy and laser flash photolysis), by studying the induction of single-strand breaks in plasmid DNA and the formation of adducts using 32P-labelled 27-mer oligonucleotides.
(20) Activation of C units persists as long as the "parent" R is occupied and is maintained for an additional short time interval (Tp) after RO reverts to RU, corresponding to hormone dissociation from receptor.
Ruins
Definition:
Example Sentences:
(1) Because they generally have to be positioned on hills to get the maximum benefits of the wind, some complain that they ruin the landscape.
(2) Even regional allies disagree with American priorities about Isis, Biddle noted, which is why Turkey continues to bomb Kurds and Saudi Arabia and the UAE arm groups around the region , most notably in Syria but also in the ruins of Yemen .
(3) It trickled back to me somehow that, ‘Goddammit, Johnny Depp’s ruining the film!
(4) A procedure is described for the rapid determination of putrascine, spermine and spermidine in ruine and whole blood.
(5) Hitchcock's attempts to keep Hedren in a gilded cage arguably ruined her career.
(6) Conference, five years ago this motion would have ruined my life.
(7) But illegal action will only ruin any chance of dialogue with Tehran.
(8) The lid is fiddly to fit on to the cup, and smells so strongly of silicone it almost entirely ruins the taste of the coffee if you don’t remove it.
(9) In Niki Savva’s book The Road to Ruin: How Tony Abbott and Peta Credlin Destroyed Their Own Government, Credlin has even been compared to Wallis Simpson, a deeply weird analogy.
(10) "While the country is sunk in misery, families are ruined and children are growing up in poverty, this guy turns up and we pay €91m for him.
(11) Anuraj Sivarajah, online editor of the newspaper, said he was very clear who was to blame for the attacks and arson that has brought the newspaper near financial ruin.
(12) In 1995 8,000 people whose lives were ruined by the Montserrat volcano settled in Britain.
(13) They belong to the people who built Choquequirao, one of the most remote Inca settlements in the Andes, and were stashed here by the archaeologists who, over the past 20 years, have been slowly freeing the ruins from the cloud forest.
(14) Even the avuncular governor of the Irish central bank, Professor Patrick Honohan, was forced to admit that pumping up to €70bn of taxpayers' money into the ruined banks "doesn't score highly on fairness" when he announced the fifth bailout on Thursday.
(15) Three thousand cheers for Will Self ( Has English Heritage ruined Stonehenge?
(16) But Denton’s attempts to apply extreme openness to others could cost the ruin of his company.
(17) His torturers accused him of passing on to British officials information about previous beatings at the hands of state officials and other human rights abuses, to ruin diplomatic relations between the two countries, he said.
(18) As Google states, it is definitely in the company’s best interest to get its first smartglass customers to behave, as “breaking the rules or being rude will not get businesses excited about Glass and will ruin it for other Explorers”.
(19) The notion that Gleeson has lurched from one disaster to another, ruining everything from the Coen brothers' remake of True Grit to Richard Curtis's romcom About Time , seems a pretty unique interpretation of his burgeoning career as a versatile character actor.
(20) But there was scepticism over whether the more radical elements on either side would obey the ceasefire, and concern in Kiev and western capitals that the truce would effectively "freeze" the conflict and give Moscow de facto control over the disputed chunk of eastern Ukraine that has been ruined by war this summer.