(1) Moreover, the ribosylation inhibitors converted the glucocorticoid antagonist RU-486 into a potent agonist for cytolysis of L1210 cells.
(2) Decreased levels of receptors for estradiol-17beta, progesterone, and prolactin were found in the tumors remaining after ovariectomy while treatment with the dose (24 mug) of RU 16117, efficient to inhibit tumor growth, has a similar inhibitory effect on the levels of estradiol-17beta and prolactin receptors.
(3) Another two derivatives of RU 486, RU 42848 (didemethyl) and RU 42698 (propargyl), had lower RBA's than RU 486.
(4) Of these two pretreatment alternatives, RU 486 alone has the advantage of a shorter hospital stay.
(5) The in vitro susceptibility of Mycobacterium tuberculosis to a new macrolide antibiotic RU-28965, alone and in combination with rifampicin or isoniazid, was studied by the agar dilution method.
(6) Ru also increased to approximately double its control value.
(7) Raman intensities measured at 815 and 1100 cm-1 in spectra of poly (rI) and poly (rU)-poly (rA)-poly(rU) indicate that the correlation previously established for single- and double-stranded ribopolymer structures is valid also for these multi-stranded structures.
(8) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(9) Renal vascular resistance decreased during RU 486 administration in anesthetized (-25%) and unanesthetized (-19%) rats.
(10) Pretreatment of the lower airways with inhaled atropine did not affect the magnitude of the changes in Ru after inhalation of OA through the nose but significantly attenuated the response of the lower airways.
(11) The direct effect of RU 486 on LH secretion in the absence of exogenous progesterone was evaluated in cells cultured in the absence or presence of 10(-9) M estradiol and then treated for 4 to 24 h with increasing concentrations of RU 486 (10(-12) to 10(-5) M) and stimulated with GnRH (10(-9) M) during the last 3 h of incubation.
(12) Frances' highest administrative court ruled that the French government exceeded its authority in ordering the distribution of RU 497 (mifepristone), but ruled that French abortion law, allowing abortions in the 1st 10 weeks in "situations of distress," did not violate international treaties guaranteeing the "right to life."
(13) Interruption of early pregnancy is a major indication for RU-486.
(14) R units are either occupied (RO) or unoccupied (RU); C units are either active (CA) or inactive (CI).
(15) We report here on developmental changes in [3H]RU 28362 (glucocorticoid receptor) and [3H]aldosterone (mineralocorticoid receptor) binding capacity in soluble fractions prepared from hippocampal tissue.
(16) The antiglucocorticoid activity of the molecule can be demonstrated in humans by a rise in plasma cortisol, ACTH and LPH after RU 486 intake, and by blockade of some peripheral effects of cortisol.
(17) The antiprogesterone RU 486 was utilized to evaluate the possible role of progesterone in ovum maturation, ovulation, fertilization, and embryo cleavage.
(18) The selective D2 dopaminergic antagonists sulpiride (10(-5) M) totally abolished the effect of RU 24926 and partially abolished the effect of lisuride.
(19) The interaction of complexes Ru(bpy)n(TAP)3-n2+ (1a-1d for n = 0-3) with DNA has been investigated using photophysical methods (emission spectroscopy and laser flash photolysis), by studying the induction of single-strand breaks in plasmid DNA and the formation of adducts using 32P-labelled 27-mer oligonucleotides.
(20) Activation of C units persists as long as the "parent" R is occupied and is maintained for an additional short time interval (Tp) after RO reverts to RU, corresponding to hormone dissociation from receptor.
Ruling
Definition:
(p. pr. & vb. n.) of Rule
(a.) Predominant; chief; reigning; controlling; as, a ruling passion; a ruling sovereign.
(a.) Used in marking or engraving lines; as, a ruling machine or pen.
(n.) The act of one who rules; ruled lines.
(n.) A decision or rule of a judge or a court, especially an oral decision, as in excluding evidence.
Example Sentences:
(1) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(2) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(3) Before issuing the ruling, the judge Shaban El-Shamy read a lengthy series of remarks detailing what he described as a litany of ills committed by the Muslim Brotherhood, including “spreading chaos and seeking to bring down the Egyptian state”.
(4) Also critical to Mr Smith's victory was the decision over lunch of the MSF technical union's delegation to abstain on the rule changes.
(5) Titre in newborn was as a rule lower than the corresponding titre of mother.
(6) Former lawmaker and historian Faraj Najm said the ruling resets Libya “back to square one” and that the choice now faced by the Tobruk-based parliament is “between bad and worse”.
(7) The exception to this rule is a cyst which can be safely aspirated under controlled conditions.
(8) This situation should lead to discuss preventive rules.
(9) Cas reduced it further to four, but the decision effectively ends Platini’s career as a football administrator because – as he pointedly noted – it rules him out of standing for the Fifa presidency in 2019.
(10) Paul Johnson, the IFS director, said: “Osborne’s new fiscal charter is much more constraining than his previous fiscal rules.
(11) Models with a C8-symmetry and D4-symmetry can be ruled out.
(12) CEA and bacterial antigens were not detected in the material, and the presence of alpha-fetoprotein, HLA and blood-group antigens may be ruled out on account of their respective molecular weights.
(13) In his notorious 1835 Minute on Education , Lord Macaulay articulated the classic reason for teaching English, but only to a small minority of Indians: “We must do our best to form a class who may be interpreters between us and the millions whom we govern; a class of persons, Indians in blood and colour, but English in taste, in opinions, in morals and in intellect.” The language was taught to a few to serve as intermediaries between the rulers and the ruled.
(14) In fact, if the roundtable operated by the rules it publishes, most of its members might have been thrown out.
(15) Injections of l-amphetamine were not effective, ruling out non-specific effects of pH, osmolarity and the like and also ruling out noradrenergic actions as explanations of the behavioral effects.
(16) My father wrote to the official who had ruled I could not ride and asked for Championships to be established for girls.
(17) The prediction rule performed well when used on a test set of data (area, 0.76).
(18) Analysts say Zuma's lawyers may try to reach agreement with the prosecutors, while he can also appeal against yesterday's ruling before the constitutional court.
(19) The ruling centre-right coalition government of Angela Merkel was dealt a blow by voters in a critical regional election on Sunday after the centre-left opposition secured a wafer-thin victory, setting the scene for a tension-filled national election in the autumn when everything will be up for grabs.
(20) But employers who have followed a fair procedure may have the right to discipline or finally dismiss any smoker who refuses to accept the new rules.