(n.) Induration; hardening; especially, that form of induration produced in an organ by increase of its interstitial connective tissue.
(n.) Hardening of the cell wall by lignification.
Example Sentences:
(1) Only group IV showed significant histological alterations such as glomerular sclerosis, interstitial damage, and increased glomerular area.
(2) We have therefore been unable to confirm that SV5 may be a major intrathecal immunogen in multiple sclerosis.
(3) Therapy was withheld after 19 months because of biliary sclerosis development.
(4) 18 patients with typical sporadic Amyotrophic Lateral Sclerosis (ALS) were investigated by the Motor Accuracy and Speed Test (MAST) and 18 healthy age- and-sex-matched volunteers, acted as controls.
(5) The thickness of the media in the groups behaves like the number of nuclei: in hypertension with the highest values, there is no significant decrease as far as the 8th cross-section, while in the coronary sclerosis and third decade groups the values come closer together after the 6th cross-section.
(6) In confirmation and extension of observations by Carp and his associates, brain tissue and sera from patients with multiple sclerosis (MS) were found to harbor an agent which induces a transitory depression in polymorphonuclear leukocytes (PMN) in mice as well as in rats, hamsters, and guinea pigs.
(7) Decreased maximal voluntary squeeze pressures were less severe in continent patients with multiple sclerosis than in incontinent patients with multiple sclerosis.
(8) This paper describes a family in which the first child, a girl born in 1988, has tuberous sclerosis (TS).
(9) Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF.
(10) Copolymer 1 (Cop 1) is a synthetic basic random copolymer of amino acids that has been shown to be effective in suppression of experimental allergic encephalomyelitis and has been proposed as a candidate drug for multiple sclerosis.
(11) Comparing areas of sclerosis on x-ray with MRI changes, the real diameter of osteochondrosis dissecans can only be seen on MRI.
(12) A recent survey revealed 237 cases of multiple sclerosis in Wellington, New Zealand, giving an overall prevalence of 69 cases per 100,000.
(13) Herpes simplex virus type 1 was isolated from the cerebrospinal fluid of a patient during the first attack of multiple sclerosis.
(14) The lesion is most commonly located in the cortex of long bones where it is associated with dense, fusiform, reactive sclerosis.
(15) As experimental findings indicated inhibitory action of aromatic retinoid on microtubule polymerisation and collagen metabolism of mesenchymal cells, we decided to treat 5 patients suffering from progressive systemic sclerosis as well as 3 patients with Sharp's syndrome with aromatic retinoid (Tigason).
(16) Previous research has suggested that patients with amyotrophic lateral sclerosis (ALS) demonstrate similar psychological characteristics that distinguish them from the medically ill populations, and that these findings may bear etiologic and prognostic importance.
(17) A study of colour vision (CV) in 65 patients with multiple sclerosis (MS), (30 patients had had previous optic neuritis) and 51 controls was carried out with Ishihara's pseudoisochromatic plates (I-test), Farnsworth's panel D-15 test (F-test), and Lanthony's desaturated 15-hue test (L-test).
(18) Expression of proteins associated with immune function was investigated immunohistochemically in postmortem brain and spinal cord of patients with amyotrophic lateral sclerosis (ALS).
(19) ‘It’s hard to understand why we have all had to go through this’ – Angelene Wright, 66, from Lincolnshire I’m a carer for my 64-year-old husband who is in the final stages of multiple sclerosis.
(20) In the present study the lesions in MRI imaging were quantified and compared with the clinical and functional abnormalities in 56 patients (27 females and 29 males) with definite multiple sclerosis (MS).
Sclerotic
Definition:
(a.) Hard; firm; indurated; -- applied especially in anatomy to the firm outer coat of the eyeball, which is often cartilaginous and sometimes bony.
(a.) Of or pertaining to the sclerotic coat of the eye; sclerotical.
(a.) Affected with sclerosis; sclerosed.
(n.) The sclerotic coat of the eye. See Illust. of Eye (d).
(a.) Pertaining to, or designating, an acid obtained from ergot or the sclerotium of a fungus growing on rye.
Example Sentences:
(1) In conclusion, increased cell turnover is a significant component of the sclerotic process both at the onset and in the late stages of this model.
(2) A sclerotic border and osteoid seams were noted, two features that seem not to have been previously reported in early lesions.
(3) The centre-left leader saw himself – and was widely regarded – as a dynamic force capable of reforming Italy after two decades of sclerotic politics.
(4) Vascular insufficiency due to sclerotic changes in vessels of various diameters undoubtedly contributes to the pathogenesis of the optic nerve impairments in the involved and clinically healthy eyes.
(5) The observers assessed the panoramic and periapical radiographs of the teeth, which were evenly distributed throughout the jaws with a 50% probability that either an osteolytic or sclerotic lesion was present.
(6) A sclerotic patriarchal social system is also to blame.
(7) Using microscopic sections of the kidney from 153 autopsies (99 SIDS infants and 54 control infants) in the National Institute of Child Health and Human Development (NICHD) Cooperative Epidemiologic Study of Risk Factors for SIDS, we counted relative numbers of sclerotic glomeruli in four fields of renal cortical tissue in two sections from each infant.
(8) In comparison to normal kidneys, a reduction in HLA class II antigens of ICAM-1 and of renal antigens defined by the monoclonal antibodies TN8-TN10 was observed in sclerotic glomeruli.
(9) The roentgenographic appearance of most lesions consisted of a radiolucent central nidus encircled by sclerotic bone.
(10) Sclerosing hemangioma of the lung (SHL) was investigated immunohistochemically, histochemically and ultrastructurally with reference to cellular components associated with the histologic pattern: cuboidal cells in the papillary type, round cells in the solid type, flat cells in the hemorrhagic type and stromal cells in the sclerotic type.
(11) The unusual histologic features were the presence of both sclerotic and cavernous hemangioma variants in the same tumor and extensive areas of calcium deposits in the tumor.
(12) The other change was a diffuse or multifocal hyperplasia of the parafollicular (C) cells that was present in other parts of the thyroid parenchyma--sometimes with gradual development of sclerotic tumors that had been exclusively formed by these cells.
(13) The distribution and configuration of the sclerotic formations in nine such cases were studied and compared by light microscopy and SEM.
(14) At 44 degrees C, LD values were decreased in patients with respect to controls for both sclerotic and and non-sclerotic skin.
(15) Examinations of 202 patients (337 eyes) with different forms of macular dystrophies, such as idiopathic flat detachment of the retina in the macular area, central sclerotic dystrophy of the retina, tapetoretinal macular degeneration, outcome of local inflammation of pigmented epithelium, post-traumatic central chorioretinitis, etc., allowed to receive data confirming high information value of a method based on the phenomenon of dynamic scotoma of disadaptation as compared with examinations on the Amsler's grid and campimetry.
(16) It was also shown that the degree of sclerotic degeneration of the thoracic aorta in group 2 was lower by 55% as compared to group 1 animals.
(17) We used light microscopy to study 87 human temporal bones (from 47 cases) with no known otological disorders, and found that certain cases had sclerotic changes around the endolymphatic duct and sac.
(18) Sclerotic changes, periosteal reaction and sequestration were present in three patients.
(19) This technique is very convenient for adult cholesteatomas developed in a sclerotic mastoid with an extension limited to mesotympanum and attic, to the children cholesteatomas developed in the mesotympanum with a sclerotic mastoid, for the correction of retraction pockets after a closed technique, rehabilitation of radical mastoidectomies, fibroadhesive otitis and some idiopathic glue tympanic membrane with a large cholesterol granuloma.
(20) Lesions in the seminal vesicles were suggestive of diminished testosterone production even though Leydig cells were discernible in the sclerotic testicular intertubular tissue.