(superl.) Having or producing scurf; covered with scurf; resembling scurf.
Example Sentences:
(1) Scurfy lesions characteristically contain a population of large blastlike cells with round to oval nuclei, a vesicular chromatin pattern, and prominent single nucleoli.
(2) The role of the thymus in the development of fatal lymphoreticular disease in the scurfy mouse was investigated.
(3) The X chromosome-linked scurfy (sf) mutant of the mouse is recognized by the scaliness of the skin from which the name is derived and results in death of affected males at about 3-4 weeks of age.
(4) Bone marrow from scurfy mice can reconstitute lethally irradiated, H-2-compatible animals but does not transmit scurfy disease.
(5) Scurfy differs from Wiskott-Aldrich syndrome in that scurfy males are consistently hypogonadal.
(6) We conclude, from these data, that scurfy lesions are mediated by T lymphocytes that mature in an abnormal (sf) thymic environment.
(7) Scurfy (sf), is an X-linked recessive lethal mutation that occurs spontaneously in the C3H mouse.
(8) Characteristic lesions in mice hemi- or homozygous for the X-linked mutation scurfy (sf) include lymphohistiocytic proliferation in the skin and lymphoid organs, Coombs' test-positive anemia, hypergammaglobulinemia, and death by 24 days of age.
(9) Thus, while our findings indicate that scurfy disease may be the result of immune dysfunction, it is not a classic immunodeficiency.
(10) Neonatal thymectomy doubles the life span of scurfy mice, moderates the histologic lesions, and prevents anemia, despite the continued presence of high levels of serum IgG.
(11) The centromere of the X (LGXX) has been tentatively assigned to the end nearest to the scurfy (sf) locus.
(12) Our studies indicate that the phenotype of hemizygous scurfy is not, as has been suggested, a model for human X-linked ichthyosis, but appears to be a disease primarily affecting the lymphoreticular, and possibly the hematopoietic, systems.
(13) Scurfy mice are negative for antinuclear antibodies.
(14) Despite their morphologically aberrant lymphoreticular system, scurfy mice can exist in a conventional environment without evidence of opportunistic infection.
(15) Scurfy (sf) is a spontaneous, sex-linked, recessive mutation that maps to the extreme proximal portion of the X chromosome, about 2 centimorgans from sparse fur (spf).
(16) Raising scurfy mice in a specific-pathogen-free environment does not alter disease expression.
Scurvy
Definition:
(n.) Covered or affected with scurf or scabs; scabby; scurfy; specifically, diseased with the scurvy.
(n.) Vile; mean; low; vulgar; contemptible.
(n.) A disease characterized by livid spots, especially about the thighs and legs, due to extravasation of blood, and by spongy gums, and bleeding from almost all the mucous membranes. It is accompanied by paleness, languor, depression, and general debility. It is occasioned by confinement, innutritious food, and hard labor, but especially by lack of fresh vegetable food, or confinement for a long time to a limited range of food, which is incapable of repairing the waste of the system. It was formerly prevalent among sailors and soldiers.
Example Sentences:
(1) This symptom is connected with high blood levels of cortisol, which are probably also involved in the injuries to connective tissue known in scurvy.
(2) We report three patients who highlight the epidemiology, clinical features, and differential diagnosis of scurvy.
(3) Scurvy developed in a 56-year-old man with poor dietary intake and was associated with knee hemarthroses and synovial thickening.
(4) This was soon accompanied by other “medicinal” drinks such as the gimlet, to avoid scurvy on ship, and pink gin, which was said to help seasickness.
(5) This study shows that guinea pigs fed 100 times the amount of vitamin C needed for growth and for prevention of scurvy have elevated levels of complement component C1q.
(6) Feed samples were submitted to a laboratory for analysis and were confirmed deficient in vitamin C. Follow-up radiographs showed large calcifying subperiosteal hematomas in epiphyseometaphyseal regions, consistent with a diagnosis of scurvy.
(7) A case of scurvy during prolonged stay in hospital is presented.
(8) In either case it implies the accumulation in scurvy of low-molecular-weight peptides enriched in proline and deficient in hydroxyproline and could explain the failure to accumulate a high-molecular-weight collagen deficient in hydroxyproline.
(9) Scurvy, which is caused by a deficiency in vitamin C, is mostly attributed to the decreased synthesis of collagen.
(10) Total IGFBP-3 in the experimental sera was increased about 30%, while there was little effect of scurvy or fasting on the level of BP-3 activity isolated by acid extraction of the high mol wt region of the S200 column.
(11) Familiarity with the risk factors for and clinical manifestation of scurvy can facilitate earlier diagnosis.
(12) Two types of pathologic state are unquestionably the concern of vitaminotherapy: More or less specific and intense vitamin deficiencies: Rickets, scurvy, beri beri, pellagra, vitamin deficiency related to alcohol consumption, polyneuritis, encephalopathy, malabsorption, mucoviscidosis, etc.
(13) The incidental discovery of scurvy in a patient with a symptomatic hiatal hernia has led to the identification of 9 other individuals with chemically proved vitamin C deficiency secondary to an expressed aversion to "acid" food in any form.
(14) The osteogenic disorder Shionogi (ODS) rat is a mutant Wistar rat that is subject to scurvy, because it lacks L-gulono-gamma-lactone oxidase, a key enzyme in L-ascorbic acid biosynthesis.
(15) Old people living alone and in poverty are most at risk for developing scurvy, but the diagnosis may be missed unless the physician is aware of it.
(16) In OD rats, the dietary requirement of ascorbic acid to maintain normal growth and prevent any signs of scurvy is about 300 mg of ascorbic acid per kilogram diet.
(17) Clinical manifestations of scurvy were exhibited, however, when animals receiving no ascorbic acid supplement were treated with the steroid hormones for 7 d. All of these animals died by d 10.
(18) The common cold studies indicate that the amounts of vitamin C which safely protect from scurvy may still be too low to provide an efficient rate for other reactions, possibly antioxidant in nature, in infected people.
(19) Moderate vitamin C deficiency, in the absence of scurvy, results in alteration of antioxidant chemistries and may permit increased oxidative damage.
(20) This is illustrated by some epidemiological examples (ergotism, scurvy, yellow fever, English sweat, diphtheria and malaria).