(1) The results support the speculation that the product of SELD is a phosphoselenoate with the phosphate moiety derived phosphoselenoate from the gamma-phosphate group of ATP.
(2) The biological activities of the wild type and mutant proteins were studied using E. coli MB08 (selD-) transformed with plasmids containing the selD genes.
(3) Purified SELD protein is a monomer of 37 kDa in its native state and catalyses a selenium-dependent ATP-cleavage reaction delivering AMP and releasing the beta-phosphate as orthophosphate.
(4) Moreover, synthesis of enzymically active protein in a transformed E. coli selD mutant strain indicated that there is a nonspecific mechanism of selenocysteine incorporation.
(5) Transformation of the mutant Salmonella strain with a plasmid bearing the E. coli selD gene restored formate dehydrogenase activity, 75Se incorporation into formate dehydrogenase seleno-polypeptides and [75Se]seleno-tRNA synthesis.
(6) Mutation of a single gene, referred to as selA1 in Salmonella typhimurium and as selD in Escherichia coli, results in the inability of these organisms to insert selenium specifically into the selenopolypeptides of formate dehydrogenase and into the 2-selenouridine residues of tRNAs.
(7) The formation of selenocysteine depended on the presence of functional products of the selA and selD genes but not of the selB gene.
(8) 4) SELD however, was accompanied by the longer duration of surgery with more blood loss and by higher incidence of complications, than conventional R2, R3 dissection.
(9) This fact seems to warrant SELD for advanced gastric cancer.
(10) Complementation of the mutation in S. typhimurium with the selD gene from E. coli indicates functional identity of the selA1 and selD genes.
(11) For male Ss, verbal reinforcement increased self-disclosure relative to the interviewer seld-disclosure condition.
(12) In the absence of the complementary enzyme(s), the SELD protein catalyzes the synthesis of a labile selenium donor compound from selenide and ATP.
(13) The longer initiated just upstream of the orf183 gene, whereas the 5' end of the other mapped in a 116-bp nontranslated region between orf183 and selD.
(14) Four genes have been identified so far: selA and selB (at the fdhA locus), selC (previously fdhC), and selD (previously fdhB).
(15) It was precluded that any putative covalent or non-covalent ligand of SELD not removed during purification participated in the reaction.
(16) However, supplementation of the deficient enzyme preparation with the purified selD gene product (SELD protein) restored synthesis of seleno-tRNAs.
(17) Transformation with an additional plasmid carrying an E. coli formate dehydrogenase selenopolypeptide-lacZ gene fusion showed that the selD gene allowed readthrough of the UGA codon and synthesis of beta-galactosidase in the Salmonella mutant.
(18) The selD gene from Escherichia coli, whose product is involved in selenium metabolism, has been cloned and sequenced.
(19) Gene disruption experiments demonstrated that the SelD protein is required both for the incorporation of selenium into the modified nucleoside 5-methylaminomethyl-2-selenouridine of tRNA and for the biosynthesis of selenocysteine from an L-serine residue esterbonded to tRNA(Ser)(UCA).
(20) One hundred and sixty three cases of gastric cancer, treated with SELD is reviewed.
Uncommon
Definition:
(a.) Not common; unusual; infrequent; rare; hence, remarkable; strange; as, an uncommon season; an uncommon degree of cold or heat; uncommon courage.
Example Sentences:
(1) Periosteal chondroma is an uncommon benign cartilagenous lesion, and its importance lies primarily in its characteristic radiographic and pathologic appearance which should be of assistance in the differential diagnosis of eccentric lesions of bones.
(2) Patients with sarcoidosis that present only cutaneous lesions are uncommon but have been described.
(3) Leprosy is an uncommon disease in Saudi population.
(4) Three diagnoses or less per patient were not uncommon; more than three diagnoses per patient were uncommon.
(5) Aneurysmal bone cyst is an uncommon benign lesion that rarely presents in the craniofacial region.
(6) We conclude that inflammatory lesions at these sites are not uncommon and that CT scans are diagnostic in the great majority.
(7) It is uncommon in children and usually associated with disease not localised to the gallbladder.
(8) The peculiar aspects of uncommon causes of IVH are discussed on the basis of a review of the literature.
(9) Although uncommon, the occurrence of seizures and elevated aminotransferase values are potentially serious side effects of clomipramine.
(10) ST-segment elevation is an uncommon finding in these patients and does not reliably differentiate those with and without fixed CAD.
(11) Substantial variations were identified in the point of origin of 6 of 41 arterial branches; extra vessels and absence of vessels were uncommon.
(12) When arterial lines are maintained for even a few days, it is not uncommon that some form of complication develops at the arterial site, such as redness, inflammation, positional problems, or even infection.
(13) Efferent units with spontaneous activity were uncommon at the start of the recording sessions but were more frequently encountered later in the experiments.
(14) While acromioclavicular joint injury is not uncommon, a complete posterior dislocation in which the distal clavicle penetrates and is entrapped by the trapezius muscle is among the most rare.
(15) D. latum infection has been an uncommon intestinal parasitosis, but it tends to increase nowadays.
(16) Sudden death in healthy athletes is uncommon but, when it occurs, the primary mechanism is cardiovascular.
(17) The literature on this uncommon syndrome was reviewed and it was found that there are an open prevalence of this entity in children younger than 15 years, as well as severe respiratory complications in affected patients.
(18) It is not uncommon for thyrotoxicosis to appear in an atypical manner in older patients.
(19) Foregut cysts are uncommon congenital defects of the developing airway and gut.
(20) Strains of this phage type were uncommon among patients attending the casualty department, and those found were usually either fully sensitive to antibiotics or resistant to benzylpenicillin only.