(a.) Growing old; decaying with the lapse of time.
Example Sentences:
(1) The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
(2) In senescent rats, however, the proportions of salt-soluble and detergent-soluble AChE may differ from those in young rats.
(3) In addition, we have shown that long-lived, presumably non-senescent, strains do not arise by suppressor mutation, but lose senescence plasmid DNA by another mechanism.
(4) Senescent (26-28 months) Fischer 344 rats were shown to have a lower density of D2 sites (-36%) without any change in affinity in membranes prepared from homogenized caudate-putamen (CPU), as compared to young adult (5-6 months) rats.
(5) The cell cycle-dependent changes in the transglutaminase mRNA levels strongly support the implicated involvement of the enzyme in cell growth, differentiation, and senescence.
(6) The increased levels of HK1 could affect other erythrocyte metabolic pathways slowing down the physiological rate of cellular senescence and result in increased activity levels of other cell-age-dependent enzymes.
(7) Advancing age was associated with a reduction in cell proliferative responses to PHA in both substrains, although the rate of decline was significantly more rapid in the senescence-prone animals.
(8) Instead of degenerative changes, these results show an activation of the vasopressinergic system in senescence and in SDAT patients, similar to earlier observations in the aged rat and in accordance with a rise in human neurophysin and VP levels reported recently.
(9) Thus, constitutive expression of specific cytochrome P450 genes is repressed or activated in senescent rats.
(10) Mild daily exercise, maintained throughout adult life into early senescence, attenuates muscle atrophy and promotes adaptive enzymatic changes in atrophying muscles.
(11) A second set of experiments which involved the injection of E2 into senescent male as well as female rats indicated that there were no sex differences in improvements in inclined screen performance, and that once the E2 injections were discontinued, performance returned to preadministration levels.
(12) Additionally, analysis of the multiple steps occurring in the El cultures, as well as in the emergence of the continuous cell lines, could potentially elucidate the processes occurring during human epithelial cell carcinogenesis and escape from senescence.
(13) Significant anamnestic SIgA responses were shown after oral immunization with DNP-BGG in adult rats, but was not observed in the senescent and midlife (10-12 months) rats.
(14) Modulation of cellular senescence by growth factors, hormones, and genetic manipulation is contrasted, but newer studies in oncogene involvement are omitted.
(15) Under the same conditions, PM from senescent mice generated 62% of the initial O2- produced in response to zymosan, and 45% in response to OZ.
(16) Untreated cells, or cells treated with MCA or TPA only, usually became senescent around 6-8 weeks after plating and died, but those treated with both MCA and TPA became immortalised and underwent transformation to a phenotype capable of growth in soft agar.
(17) Because immune senescence most profoundly affects T lymphocyte functions, we suspected that LIA production would decline with age.
(18) Abnormal granular structures, which stained positively with periodic acid-Schiff (PAS-positive granular structures; PGS), were observed in the brain of senescence accelerated mouse (SAM).
(19) In senescent females the number of small IMPs was decreased in the perikarya and dendritic shafts compared to young females while the number of large particles was increased in the outer leaflet of the membrane of dendritic shafts, reaching values similar to those observed in males.
(20) Our data suggest that the release of u-PA antigen by human macrovascular endothelial cells can be used as an indicator of cell senescence.
Seniority
Definition:
(n.) The quality or state of being senior.
Example Sentences:
(1) Brown's model, which goes far further than those from any other senior Labour figure, and the modest new income tax powers for Holyrood devised when he was prime minister, edge the party much closer to the quasi-federal plans championed by the Liberal Democrats.
(2) Faisal Abu Shahla, a senior official in Fatah, an organisation responsible for a good deal of repression of its own when it was in power, accuses Hamas of holding 700 political prisoners in Gaza as part of a broad campaign to suppress dissent.
(3) Mike Enzi of Wyoming A senior senator from Wyoming, Enzi worked for the Department of Interior and the private Black Hills Corporation before being elected to Congress.
(4) "Especially at a time when they are turning down voluntary requests and securing the positions of senior managers."
(5) A Palestinian delegation was to hold truce talks on Sunday in Cairo with senior US and Egyptian officials, but Israel has said it sees no point in sending its negotiators to the meeting, citing what it says are Hamas breaches of previous agreed truces.
(6) Also, it is often the case that trustees or senior leadership are in said positions because they have personal relationships with the founder.
(7) His senior role in the Popalzai tribe and his chairmanship since 2005 of Kandahar provincial council bolstered his reputation as an Asian version of a mafia don.
(8) It is understood that Cooper rejected pressure from senior Labour figures last week for both her and Liz Kendall to drop out and leave the way clear for Burnham to contest Corbyn alone.
(9) They are saying they have paid with their blood and they do not want to retreat," said Saad el-Hosseini, a senior Brotherhood politician.
(10) "We won't cancel any of our agreements," a senior Israeli diplomatic official told reporters.
(11) A senior shadow minister, who has not been named by the Telegraph in its exposé of MPs' expenses , was yesterday asked by county councillors not to campaign for next month's local elections.
(12) Sir James Crosby, the ITV senior independent non-executive director, explained why the board had opted to retain Grade's services for an extra year: "It was the unanimous view of ITV's independent non-executive directors that it would be in the best interests of the company and its shareholders to ask Michael to extend his time as executive chairman.
(13) Lisette van Vliet, a senior policy adviser to the Health and Environment Alliance, blamed pressure from the UK and German ministries and industry for delaying public protection from chronic diseases and environmental damage.
(14) "Android’s gain came mainly at the expense of BlackBerry, which saw its global smartphone share dip from 4 percent to 1 percent in the past year due to a weak line-up of BB10 devices," said Strategy Analytics' senior analyst Scott Bicheno.
(15) Sajeda Amin is a senior associate at the Population Council .
(16) Tim Moore, senior economist at Markit, said: "Construction is no longer the weakest link in the UK economy.
(17) One hundred cases of histologically proven corneal and conjunctival tumours were extracted from the records at the Princess Alexandra Hospital and from the senior author's private practice in the last ten years.
(18) The Dacre review panel, which included Sir Joseph Pilling, a retired senior civil servant, and the historian Prof Sir David Cannadine, said Britain now had one of the "less liberal" regimes in Europe for access to confidential government papers and that reform was needed to restore some trust between politicians and people.
(19) Senior sources said on Monday that the vacancies had left it in effect rudderless, and unable to introduce any significant reforms.
(20) Top 10 Arpad Cseh Senior investment director, UBS Alice La Trobe Weston Executive director, head of European credit research, MSIM Morgan Stanley Katie Garrett Executive director, senior engineer, Goldman Sachs Alix Ainsley, Charlotte Cherry H R director, group operations (job share), Lloyds Banking Group Matt Dawson Director for business development, The Instant Group Angela Kitching, Hannah Pearce Head of external affairs (job share), Age UK Morwen Williams Head of newsgathering operations, BBC Georgina Faulkner Head of Sky multisports, Sky Maggie Stilwell Managing partner for talent, UK & Ireland, EY Sarah Moore Partner, PwC