(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Shad
Definition:
(n. sing. & pl.) Any one of several species of food fishes of the Herring family. The American species (Clupea sapidissima), which is abundant on the Atlantic coast and ascends the larger rivers in spring to spawn, is an important market fish. The European allice shad, or alose (C. alosa), and the twaite shad. (C. finta), are less important species.
Example Sentences:
(1) New Jaguars owner Shad Khan said when he bought the team that he wanted to make a "splash" in free agency.
(2) So part of what Shad will be tasked for at Arsenal, and what we were tasked for with the DFB, is to integrate.
(3) Shad genuinely cares and will work extremely hard player by player, peer to peer, to help execute the vision Mr Wenger has laid out.
(4) In the present study, a cytostatic tumor growth inhibitory peptide and a tumor growth promoting peptide with molecular weights of 20,000-30,000 Da have been identified in the supernatant fraction of unfertilized ova from Shad.
(5) From Denis MacShane: Bumped into 2 shad cab Tories in Indian rest.
(6) The dead twaite shad, small whitish gray fish, were discovered Tuesday by inspectors conducting routine water testing in Rio’s sewage and rubbish-filled Guanabara Bay.
(7) Same old Arsenal in that sense and something that was meant to become less so following the summer appointment of the fitness expert Shad Forsythe , a key component of Germany’s World Cup-winning triumph in Brazil .
(8) By blocking the rivers and silting up the spawning beds, they helped bring to an end the gigantic runs of migratory fish that were once among our great natural spectacles and which fed much of Britain – wiping out sturgeon , lampreys and shad , as well as most sea trout and salmon.
(9) PCB residues exceeding the tolerance level of Health and Welfare Canada were found in the following: from Lake Saint Clair, smallmouth bass (Micropterus dolomieui) in 1975 and channel catfish (Ictalurus punctatus) in 1971; from Lake Erie, coho salmon (Oncorhynchus kisutch) in 1970, smallmouth bass, alewife (Alosa pseudoharengus), freshwater drum (Aplodinotus grunniens), and gizzard shad (Dorosoma cepedianum) in 1971, and white bass in 1971 and 1976.
(10) 20 Fenchurch Street has DESTROYED the view through Tower Bridge from Shad Thames area.
(11) Tower 42 featured in the BBC’s Sherlock TV series, as Shad Shanderson, the financial institution used in the Blind Banker episode.
(12) We are now going to invest, in this case with Shad.
(13) Two subjects each were exposed to pressure equivalents of 50 (SHAD I) and 60 (SHAD II) feet of sea water gauge (FSWG) for 30 and 28 d, respectively.
(14) Unfertilized ova from Shad, a North Atlantic herring, contains a cytostatic inhibitor of T lymphocyte blastogenesis.
(15) Shad Forsythe Has held many roles in training, including at the US Olympic Training Centre in San Diego.
(16) "For dinner I order the shad-roe ravioli with apple compote as an appetiser and the meat loaf with chèvre and quail-stock sauce for an entrée".
(17) It is found in certain series where primary tumors and pulmonary metastase shad been seperately studied.
(18) At least 30,000 salmon and tens of thousands of shads, lampreys and sea trout use the estuary to reach spawning grounds in the Usk and Wye rivers.
(19) Shad Forsythe, a new fitness coach at Arsenal – headhunted to invigorate their training regime – was one of four specialists who were embedded with Joachim Löw’s team every step, every stretch, every session of the way at the World Cup.
(20) Significantly higher levels of six organochlorine residues were found in the gonad tissue of striped bass; however, similar studies on gonad tissue of American Shad, harvested from the same region, show no such enhancement.