(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Shag
Definition:
(n.) Coarse hair or nap; rough, woolly hair.
(n.) A kind of cloth having a long, coarse nap.
(n.) A kind of prepared tobacco cut fine.
(n.) Any species of cormorant.
(a.) Hairy; shaggy.
(v. t.) To make hairy or shaggy; hence, to make rough.
Example Sentences:
(1) "Because people didn't see me falling out of clubs or shagging in the alleys with different girls every week, they thought something was wrong with me.
(2) This is a guy whose last feature, Trash Humpers , was 80 minutes of old people shagging foliage.
(3) Voteman aims to get young people voting by slapping them around the chops, decapitating them, or simply hurling them into the voting booth like the shagging, lazy slackers they are.
(4) It's the difference between a quick shag and an all-night lovemaking session!"
(5) The movie was shot last year during a real spring break in St Petersburg, Florida, amid the kind of week-long teen chaos – motels on fire, pools filled with furniture, kids shagging in the street – that it takes a resort town a year to recover from.
(6) During Friday's hearing, White referred to an email she sent to a newspaper providing a tip about Nick Clegg's sex life, known as the "18 shags story" and said "it suggests something about her attitude".
(7) The relatively low activity of these enzymes is probably the main reason why the shag has been found to contain relatively high levels of dieldrin in ecological studies.
(8) "A shag", Ferdinand explained when asked what the gesture meant.
(9) I didn't look like I was supposed to because I'd been Barbarella and now I had this short, brown shag that became famous in Klute.
(10) You shagged your team-mate's missus, you're a cunt."
(11) A sports commentator was cut loose from his radio station this week for sending a tweet that read: "To all fellow women journalists: shag wisely, you could become the next first lady of France."
(12) We shouldn’t beat ourselves up about one-night stands or walks of shame.” The idea of your 20s as a carefree period before a woman starts her “real” life of monogamy and child-bearing is not a new one: see the end of John Cleland’s Memoirs of A Woman of Pleasure , published in 1748, where 300 pages of masturbation, orgies and lesbianism are followed by a “tail-piece of morality”, and protagonist Fanny Hill explains that she is much happier now she’s put all that filthy shagging behind her.
(13) Scattering out around the goals and small pitches informal games are played in mixed groups as pretty much every kid here takes a turn to demonstrate their range of tricks, traps and flicks on that wondrous green shag.
(14) She also caused some offence in 2005 when she suggested on air, in the wake of revelations about John Prescott's extra-marital activities, that his nickname should be changed from "two jags" to "two shags".
(15) Women comedians are probably not looking for shags in any case; if they were, they probably couldn't say so.
(16) Avon: "If your mate just gives us the bird he was shagging - was she a bird in Buckingham Palace?"
(17) "You shagged your team-mate's missus, you're the cunt."
(18) However, "continuing dramas" can't all be about shagging and hotpot (brilliant though that sounds).
(19) Hatchet was subjected to virulent internet abuse, some fans at United games sang songs naming and abusing his victim and declaring that Evans would “shag who he wants”.
(20) Liver microsomes of the shag showed smaller than 8% of the epoxide hydrase activity and smaller than 14% of the hydroxylating capacity of liver microsomes from the rat.