(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Shah
Definition:
(n.) The title of the supreme ruler in certain Eastern countries, especially Persia.
Example Sentences:
(1) Two “Belgian journalists” had been in the Panjshir valley of northern Afghanistan for weeks, supposedly waiting to interview Ahmad Shah Massoud, the so-called Lion of the Panjshir, leader of the anti-Taliban Northern Alliance, an al-Qaida adversary.
(2) The Shah's secret police – Savak – became increasingly brutal, ultimately detaining without trial and torturing tens of thousands of Iranian citizens.
(3) But British ambassador Sir Anthony Parsons famously got it wrong, reporting that the shah's position was secure as late as 1978.
(4) Naureen Shah, director of Amnesty International USA’s security and human rights programme, acknowledged the need for governments to assess their approach in the aftermath of major attacks but said: “What we don’t want to see is government using the Paris attacks as a pretext for extending surveillance authorities or pushing back against reforms that even the government acknowledged as necessary.” Some of the hawkish responses to events in Paris “raise a question of whether there’s an exploiting of public fear and anger and anxiety to push legislation through”, she added.
(5) Galloway accused Shah of lying about how old she was when she claimed to have been “emotionally blackmailed” into marrying a cousin in Pakistan.
(6) The 15-page speech on "the limits of law" was delivered by Sumption – once one of Britain's highest-earning barristers – at the 27th Sultan Azlan Shah Lecture in Kuala Lumpur, Malaysia, last week.
(7) Shah Ebrahim, head of the independent Cochrane Collaboration team, whose review of the benefits and side-effects of the drugs led to the Nice recommendation, also thinks the papers should be withdrawn.
(8) Naz Shah, Labour MP for Bradford West since 2015, has described misogynistic attempts to smear her by local party members.
(9) Ahmed Shah Masood, soldier and politician, born c1952; died September 15, 2001.
(10) The UK and Russia invade Iran and jointly occupy the country, forcing King Reza Shah to abdicate.
(11) Dr Umair A Shah, executive director of the Harris County department of public health, said, “It’s probably not a case of if we get Zika in our native mosquitoes, it’s probably a case of when we get Zika in our native mosquitoes.” Zika is a subtropical virus transmitted by the Aedes aegypti and Aedes albopictus mosquitoes, part of a group of diseases known as arboviruses, short for arthropod-borne viruses.
(12) The al-Qatif governorate of Eastern Province, bordering the Gulf, has been the setting for anti-regime agitation since at least 1979, when Saudi Shias demonstrated in support of Ayatollah Ruhollah Khomeini, whose Islamic revolution in Iran that year toppled the shah.
(13) Rustam Shah Mohmand, a former political agent who once administered the same tribal agency where Afridi was tried, said the case would never have succeeded in regular court.
(14) Richard Sewell's diary reveals that he and New Zealand ambassador Chris Beeby were closely involved with the ambitious plot to fly the US diplomats to safety at a time when anti-American rhetoric was at an all-time high following the overthrow of the Shah and Washington's decision to harbour its dying ally.
(15) Thus it was with the Shah of Iran in 1979, Nicolae Ceausescu in Romania in 1989 and Hosni Mubarak in Egypt earlier this year.
(16) The list includes Refaii Hamo, a Syrian refugee who arrived in Detroit in December, and Saudi-American army veteran Naveed Shah, reflections of the president’s effort to resettle 10,000 refugees and his opposition to anti-Muslim sentiment .
(17) They can probably stabilise the market, but it will be a political decision, as they will have to compel government, state agencies, banks, pension funds, insurance companies to buy,” said Ashok Shah, investment director at London & Capital.
(18) It was the early 1970s, our oil revenue had significantly increased and I spoke to His Majesty [the Shah] and [the then prime minister] Mr Amir-Abbas Hoveyda, and told them that it was the best time to buy some of our ancient works both internally and from outside.
(19) Shah Deniz 2 involves 16bn more going to Bulgaria, Greece, and Italy.
(20) They were identified as 61-year-old German doctor Eberhard Schaaf, Nepal-born Canadian Shriya Shah, and South Korean mountaineer Song Won-bin.