(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Sham
Definition:
(n.) That which deceives expectation; any trick, fraud, or device that deludes and disappoint; a make-believe; delusion; imposture, humbug.
(n.) A false front, or removable ornamental covering.
(a.) False; counterfeit; pretended; feigned; unreal; as, a sham fight.
(v. t.) To trick; to cheat; to deceive or delude with false pretenses.
(v. t.) To obtrude by fraud or imposition.
(v. t.) To assume the manner and character of; to imitate; to ape; to feign.
(v. i.) To make false pretenses; to deceive; to feign; to impose.
Example Sentences:
(1) The results indicated that smoke, as opposed to sham puffs, significantly reduced reports of cigarette craving, and local anesthesia significantly blocked this immediate reduction in craving produced by smoke inhalation.
(2) Five days later, the animals were randomly assigned to one of four treatment groups: Group 1 received intracranial implantation of controlled-release polymers containing dexamethasone; Group 2 received intraperitoneal implantation of controlled-release polymers containing dexamethasone; Group 3 received serial intraperitoneal injections of dexamethasone; and Group 4 received sham treatment.
(3) In contrast sham-hemodialysis in group CA and group PS, respectively, did not result in significant increases in amino acid efflux from the leg implying that the protein catabolic effect of blood membrane contact depends on the chemical properties of dialysis membranes.
(4) Meanwhile Ed Miliband, the Labour leader, waiting anxiously for news of the scale of the Labour advance in his first nationwide electoral test, will urge the electorate not to be duped by the promise of a coalition mark 2, predicting sham concessions by the Conservatives .
(5) The plasma renin activity of the 1 day post-stenosis rats showed 65% higher activity than the sham controls with no significant change in the 30-60 days post-stenosis.
(6) The results indicate that, regardless of the photoperiod, no clear functional relationship can be found between the avian pineal gland and thyroid function, although a transitory increase in T4 levels was seen in both pinealectomized and sham-operated birds shortly after the operations.
(7) The amounts of erythropoietin produced in animals subjected to hepatectomy are significantly higher than those observed in sham-operated animals.
(8) However, stimulation of the release of NTLI by intraduodenal administration of oleic acid (0.2 ml) resulted in significantly higher p-NTLI levels in the nephrectomized rats than in the sham operated rats.
(9) Three groups of male rats received lesions of AP and another 3 groups received sham lesion.
(10) Pretreatment with CV6209 had no significant influence on these parameters in sham-operated animals.
(11) We found that kidney extracts from 6 h and 24 h uninephrectomized rats increased [3H]thymidine incorporation into tubular cell DNA, dose-dependently, compared to those from sham-operated rats.
(12) The sizes of adrenaline (A) and noradrenaline (N) cells in the adrenal medulla of nonoperated (NO), sham-operated (SPX), and pinealectomized (PX) male rats (n = 126) were investigated by quantitative light microscopy.
(13) The concentrations and total content of the nicotinamide nucleotides were measured in the livers of rats at various times after partial hepatectomy and laparotomy (sham hepatectomy) and correlated with other events in the regeneration process.
(14) The volume densities of the differing strial components from steroid-administered animals were determined to approximate those of sham-adrenalectomized animals in general.
(15) With five daily 1-hr occlusions of the hepatic artery, rats benefited from significantly reduced tumor growth rates compared with controls that underwent sham operation (P less than 0.05).
(16) In the dynamic phase the weight of interscapular brown adipose tissue was significantly increased in the VMH-lesioned rats, but the specific GDP binding was depressed both in the morning and afternoon when compared with either the sham-operated or PVN-lesioned groups.
(17) There were no changes in the joints which had sham operations.
(18) In contrast, in Px-SUC both masses were comparable to the sham groups.
(19) Only at 3 days did total plasma volume of SAD rats show a modest reduction of about 16% (P less than 0.05 vs. sham-operated plus unoperated controls).
(20) The binding of 125I-labeled epidermal growth factor (EGF) was compared in acini isolated from the regenerating remnant following 90% partial pancreatectomy (ppx) and from the pancreas of sham-pancreatectomized (sham-ppx) rats.