(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Shan
Definition:
Example Sentences:
(1) The results showed that the drug "Shan-Dou-Gen" used in different regions in China at present are the roots or rhizomes derived from 9 species: Sophora tonkinensis Gagnep.
(2) The world's greatest snow-capped peaks, which run in a chain from the Himalayas to Tian Shan on the border of China and Kyrgyzstan, have lost no ice over the last decade, new research shows.
(3) "Since the elections there have been three broken ceasefires, with the Kachin, Karen and Shan minorities, a massive increase in army attacks on ethnic groups, and a sharp rise in gang rapes involving women and children.
(4) The survey of a population including 40-59-old males, dwellers from the rural areas of the Tien Shan and Pamirs low- and highlands, has demonstrated that atherogenic dyslipoproteinemias are significantly more infrequently encountered among high-altitude dwellers than among low-altitude ones.
(5) Ion-pairing extraction and high-performance liquid chromatography (HPLC) were employed for assaying moniliformin (a fungal toxin) content in the corn (Shaanxi) and rice (Yunnan) samples collected from families suffering from Ke-shan disease.
(6) Later, Shanly told the group in a posting: “Sorry for being expressive, apologise for any offence.” Shanly told the Times on Tuesday that he regretted the comments he made, adding: “I completely reject the accusation of bullying and I am sure those who know me from my many years of activity in the movement would know that such a label is absurd.” Momentum is open to people who are not Labour members, and some MPs who do not support Corbyn are alarmed by its rise because they fear it will enable people previously involved in far-left groups outside Labour to exercise influence in the party.
(7) In lowland (760 m above sea level) and highland (3200 m above sea level) of Tien Shan, the measurements of blood pressure and blood flow in the large vessels as well as the mass of heart ventricles of 75 rabbits have been made.
(8) It was found that at 760 m and 2800 m (Tien-Shan) a chemoreflex mechanism maintains 13 to 18% of the total volume of eupnoic ventilation regardless of the age of the subject studied.
(9) were found in the land mollusks Bradybaena duplocincta and Jaminia potaniniana asiatica collected on the slopes of Tien-Shan.
(10) It was shown that the high-altitude conditions of the Pamirs and Tien Shan (2800-3600 m above the sea-level) modified the clinicofunctional signs and a course of the cor pulmonale (CP) in chronic bronchitis.
(11) Tai Shan's arrival brought 500,000 new visitors to the zoo in 2005, the director, Dennis Kelly, said.
(12) An epidemiologic study of 40- to 59-year-old males was carried out in order to assess the effect of ethnic characteristics and migration from high-altitude (2,000-3,500 m above sea-level) Tien Shan areas to Frunze (760 m above sea-level) and vice versa on the prevalence of coronary heart disease (CHD) and coronary risk factors.
(13) As the drug "Shan-Dou-Gen" derived from different species has different actions and dosages, it is necessary to give different names to different species and use them correctly.
(14) Hemoacupuncture also was applied to Shan-gen, bilateral ear tip, and bulb points.
(15) He ventures out at night to spend time with his boy, telling Constance: "I shan't be back till late.
(16) Owing to security reasons, the Union Election Commission has cancelled voting in several hundred villages across the states of Kachin, Karen, Mon and Shan, and the Bago region.
(17) As many as 132 patients with bronchial asthma were examined for the clinical, functional and laboratory parameters before and during alpine climatotherapy at a height of 3200 m above the sea level (the Tyuya-Ashu pass, the northern Tien Shan).
(18) To demonstrate the progress made in the family medicine clinic at the Chung Shan Medical College Hospital and to evaluate the appropriateness of this kind of family practice setting, our patient population of 616 was investigated.
(19) An outbreak of Legionnaires' Disease (LD) in a college in Tang Shan in the winter of 1987 was reported.
(20) The epidemic levels of CVD in Ning-Xia and Shan-Xi were the highest, Its epidemic levels in the urban areas were higher than those in the rural areas.