(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Shaw
Definition:
(n.) A thicket; a small wood or grove.
(n.) The leaves and tops of vegetables, as of potatoes, turnips, etc.
Example Sentences:
(1) Philip Shaw, chief economist at broker Investec, expects CPI to hit 5.1%, just shy of the 5.2% reached in September 2008, as the utility hikes alone add 0.4% to inflation.
(2) Philip Shaw, chief economist at Investec, said: “Clearly, there is a much greater chance that the euro hits parity with the US dollar once again, as it first did in 1999.” Stock markets climbed and bond yields fell as the markets digested the full implications of the massive QE project that will involve the ECB buying €60bn (£45bn) of bonds a month until September 2016 or when eurozone inflation nears the central bank’s 2% target.
(3) We have to improve our playing style and beat our opponents more easily.” Van Gaal was also careful to provide an exact statement on the England full-back Luke Shaw, who suffered an ankle injury against Arsenal.
(4) Extreme Republicans in North Carolina have been trying to figure out how to restrict voting by black people ever since 2008.” He said that Shaw students who hadn’t voted at all had to think hard about their decision.
(5) Michael Holroyd, in his biography of George Bernard Shaw , gives an illuminating example of myopic hostility to Russia by the right even when we desperately needed allies.
(6) When I decided Baines might be my No1, I decided the next one would be Luke Shaw.
(7) Other high-profile absentees include Danny Welbeck, Jack Wilshere, Luke Shaw and Jordan Henderson.
(8) After removing the bulk of tissue with the Shaw scalpel, the carbon dioxide laser and dermabrader are used to refine nasal contours.
(9) Adam Lallana, Rickie Lambert and Dejan Lovren have all moved to Liverpool while Luke Shaw has signed for Manchester United and Arsenal have taken Calum Chambers to the Emirates Stadium, with Southampton raking in more than £88m for the combined deals.
(10) Lance Sergeant Darren Shaw, whose daughter was two weeks old when he left for Afghanistan, said the parade would bring closure to the Afghan tour "then we can get ready and move on to what our next tasks are".
(11) And like Warhol, he saw his own philosophy and his belief not within himself but in the world around him.” Barely drawing breath, Shaw cites a painful image of Ruskin “as a wounded animal searching for cover in a re-created world”.
(12) It would have been fantastic for Goodesy to be up there with me, but he wanted to do it his own way,” Shaw said.
(13) Responding to Shaw’s comments on possible privatisation, a Department for Transport spokesman said it awaited her recommendations on how the government should “approach the longer-term future shape and financing of Network Rail”.
(14) Elsewhere in London, at the National Theatre on the South Bank, there is another dramatic performance, of Bernard Shaw's The Doctor's Dilemma , depicting what healthcare was like a hundred years ago.
(15) The £100,000 a-week, five-year contract, on offer to Shaw is far greater than Chelsea are willing to pay and they have decided to pull out.
(16) 5.56pm GMT 26 min: Shaw whistles a low ball into the Liverpool area from the left.
(17) So I think he’s been aware of it.” Shaw’s injury explains why Danny Rose of Tottenham Hotspur has been called up as an understudy for Leighton Baines in the left-back role , at a time when Kieran Gibbs is also unavailable because of his own hamstring injury.
(18) The number of injuries he has had: Phil Jones has played only seven games this season, Ashley Young, [Antonio] Valencia, [Luke] Shaw, these are big losses.
(19) Jamie Jackson Manchester United’s Ashley Young out for ‘long time’ with serious groin injury Read more Kick-off Saturday 3pm Venue Old Trafford Last season Manchester United 0 Southampton 1 Referee Mike Jones This season G 15, Y 49, R 1, 3.40 cards per game Odds H 5-6 A 7-2 D 5-2 Manchester United Subs from Romero, Pereira, Powell, Rashford, Tuanzebem, Goss, McNair, Varela, Depay, Januzaj, Mata Doubtful None Injured Shaw (broken leg, May), Valencia (ankle, Mar), Rojo (shoulder, unknown), Carrick (unknown), Young (groin, unknown), Schweinsteiger (knee), Jones (match fitness) Suspended None Form LLDWDW Discipline Y37 R0 Leading scorer Rooney 6 Premier League: 10 things to look out for this weekend Read more Southampton Subs from Stekelenburg, K Davis, Martina, Yoshida, Clasie, Romeu, Tadic, Austin, Pelle, Juanmi Doubtful Stekelenburg (knock) Injured Rodriguez (knee, Mar), Gardos (knee, unknown) Suspended None Form LWLLWW Discipline Y38 R3 Leading scorer Pellè 6
(20) 2.44am BST Kings 3-3 Blackhawks, 2:42, 2nd period A two-on one break for the Hawks - Shaw is skating with the puck across the blue line, passes to Niklas Hjalmarsson, who gives it back, cross ice to Shaw who fires and is denied!