(1) The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1.
(2) The cloning of RK5 confirms the presence in mammals of all four Drosophila K+ channel families: Shaker, Shab, Shaw, and Shal.
(3) This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well evolved in the parent species ancestral to both invertebrate and vertebrate life.
(4) The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes.
(5) This organization precludes the generation of multiple forms of the protein by alternative RNA splicing, a mechanism known to characterize the Drosophila potassium channel genes Shaker and Shab.
(6) Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.
(7) In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.
(8) In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel.
(9) Mouse and Drosophila Shab K+ channels (mShab and fShab, respectively) represent an instance of K+ channels and structurally related species that are both functionally and structurally conserved; most kinetic, voltage-sensitive, and pharmacological properties are similar for the 2 channels.
(10) We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present.
(11) One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product.
(12) The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively.
(13) Structurally, drk1 encodes an amino-acid sequence which is more closely related to the Drosophila Shab gene than to the Shaker gene.
(14) Shaker, Shal, Shab, and Shaw K+ channels have similar structures, but appear to be independent channel systems: when co-expressed in Xenopus oocytes, all four function independently.
(15) The deduced proteins of Shab, Shaw, and Shal have high homology to the Shaker protein; the sequence identity of the integral membrane portions is greater than 50 percent.
(16) By using a Shaker complementary DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal.
(17) We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel.
Shay
Definition:
(n.) A chaise.
Example Sentences:
(1) A series of alkylazulene-1-sodium sulfonate derivatives which has an isopropyl group at 6-position were synthesized, and their anti-ulcer activities were examined in Shay pylorus-ligated rats.
(2) Joe Cole made his full debut for Villa and Shay Given made his first appearance since January 2013, while Darren Bent started a game for the first time since the final day of the 2012-13 season.
(3) Shay Given could have been mistaken for just another Irish tourist on the Algarve until he was forced to work just after the half-hour, saving a couple of long-range strikes by Liam Walker.
(4) Shay Given and Craig Bellamy (a player he did sign for Blackburn) have been excellent, with pinching Gareth Barry from under Liverpool's nose one of the manager's best bits of business.
(5) The Obama administration must back international efforts to achieve zero carbon emissions by 2050,” said Shaye Wolf, the climate science director with the Center for Biological Diversity.
(6) Mucosa damage, these appear in the Shay ulcer model before the macroscopic ulceration, can be prevented by the selective proximal vagotomy.
(7) The results illustrate that gastric diversion is accurate and suitable for basal acid output estimation and it is suggested as a valuable substitute for the classical Shay rat procedure, allowing gastric secretion collection over 6 h without gastric mucosal injury.
(8) When Yemeni journalist Abdulelah Haider Shaye receives a coveted Human Rights Defenders award in Geneva , his role as a fearless chronicler of his country's US-led drone war will have come full circle.
(9) President Abed Rabbo Mansour Hadi reversed that decision in May, issuing an order to release Shaye "soon", according to the London Times correspondent Iona Craig, who covered the case extensively.
(10) Benzimidazole and some of its derivatives as 4-nitro and 5-nitro-benzimidazoles, 2-amino-, 4-amino- and 5-aminobenzimidazoles have been tested on gastric acid secretion in Shay-rats.
(11) Captain Kristen Griest, 26, and first lieutenant Shaye Haver, 25, graduated from the prestigious school in Fort Benning, Georgia , with 94 male classmates who successfully finished three arduous phases of training, lasting months in total.
(12) Shay ulceration and gastric lesions induced by cold-restraint stress and ulcerogenic agents, such as acetylsalicylic acid (ASA), reserpine, or epinephrine, in rats were significantly aggravated by pregnancy (day 20 of pregnancy).
(13) delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test).
(14) Up the road in Halifax, however, they hit upon an enterprising idea: why not use the Shay for ice-skating?
(15) Shaye's coverage shed more light than any other individual on the scope of the US drone warfare programme and kept him in the cross hairs of both governments.
(16) In Shay-rats a dose dependent inhibitory effect of salmon calcitonin on ulcer formation and gastric secretion is demonstrated.
(17) In the present study the effects of these substances were examined using the Shay-model.
(18) The alpha-cell cycle was very significantly depressed and the beta + gamma-cell cycle was increased in three different rat leukemias (L5222, Shay, BNML), growing on three different rat strains (BDIX, Holtzmann, Brown Norway).
(19) Speed's former Newcastle United teammate Shay Given, who attended a charity fundraising event with him in May, broke down in tears on television as a minute's silence was held at the start of Swansea City's match against Aston Villa.
(20) Bowing to the pressure, then-president Ali Abdullah Saleh pardoned Shaye weeks after his sentencing.