(superl.) Having a very thin edge or fine point; of a nature to cut or pierce easily; not blunt or dull; keen.
(superl.) Terminating in a point or edge; not obtuse or rounded; somewhat pointed or edged; peaked or ridged; as, a sharp hill; sharp features.
(superl.) Affecting the sense as if pointed or cutting, keen, penetrating, acute: to the taste or smell, pungent, acid, sour, as ammonia has a sharp taste and odor; to the hearing, piercing, shrill, as a sharp sound or voice; to the eye, instantaneously brilliant, dazzling, as a sharp flash.
(superl.) High in pitch; acute; as, a sharp note or tone.
(superl.) Raised a semitone in pitch; as, C sharp (C/), which is a half step, or semitone, higher than C.
(superl.) So high as to be out of tune, or above true pitch; as, the tone is sharp; that instrument is sharp. Opposed in all these senses to flat.
(superl.) Very trying to the feelings; piercing; keen; severe; painful; distressing; as, sharp pain, weather; a sharp and frosty air.
(superl.) Cutting in language or import; biting; sarcastic; cruel; harsh; rigorous; severe; as, a sharp rebuke.
(superl.) Of keen perception; quick to discern or distinguish; having nice discrimination; acute; penetrating; sagacious; clever; as, a sharp eye; sharp sight, hearing, or judgment.
(superl.) Eager in pursuit; keen in quest; impatient for gratification; keen; as, a sharp appetite.
(superl.) Keenly or unduly attentive to one's own interest; close and exact in dealing; shrewd; as, a sharp dealer; a sharp customer.
(superl.) Composed of hard, angular grains; gritty; as, sharp sand.
(superl.) Steep; precipitous; abrupt; as, a sharp ascent or descent; a sharp turn or curve.
(superl.) Uttered in a whisper, or with the breath alone, without voice, as certain consonants, such as p, k, t, f; surd; nonvocal; aspirated.
(adv.) To a point or edge; piercingly; eagerly; sharply.
(adv.) Precisely; exactly; as, we shall start at ten o'clock sharp.
(n.) A sharp tool or weapon.
(n.) The character [/] used to indicate that the note before which it is placed is to be raised a half step, or semitone, in pitch.
(n.) A sharp tone or note.
(n.) A portion of a stream where the water runs very rapidly.
(n.) A sewing needle having a very slender point; a needle of the most pointed of the three grades, blunts, betweens, and sharps.
(n.) Same as Middlings, 1.
(n.) An expert.
(v. t.) To sharpen.
(v. t.) To raise above the proper pitch; to elevate the tone of; especially, to raise a half step, or semitone, above the natural tone.
(v. i.) To play tricks in bargaining; to act the sharper.
(v. i.) To sing above the proper pitch.
Example Sentences:
(1) Basal 20 alpha DHP levels remained low until a sharp rise at mid pro-oestrus.
(2) Whole-virus vaccines prepared by Merck Sharp and Dohme (West Point, Pa.) and Merrell-National Laboratories (Cincinnati, Ohio) and subunit vaccines prepared by Parke, Davis and Company (Detroit, Mich.) and Wyeth Laboratories (Philadelphia, Pa.) were given intramuscularly in concentrations of 800, 400, or 200 chick cell-agglutinating units per dose.
(3) Gonadectomy of females was accompanied by changes in the activity of individual HAS links in different direction--some reduction of ACTH in the hypophysis, a sharp and significant fall of the peripheral blood glucocorticoid level and a marked significant elevation of hydrococortisone production in the adrenal cortex in vitro.
(4) The University of the Arts London and Sunderland, Sheffield Hallam, Manchester Met and Leeds Met university have also experienced sharp declines in applications.
(5) A sharp decrease in oxygen uptake occurred in Neurospora crassa cells that were transferred from 30 degrees C to 45 degrees C, and the respiration that resumed later at 45 degrees C was cyanide-insensitive.
(6) In contrast to findings in the rat and dog, no sharp drop but a gradual fall in CLi was observed at decreasing FENa values down to 0.02%.
(7) A more specific differentiation, as indicated by the sharp increase in GAD levels which was concurrent with an increase in interneuronal contacts, lagged behind the initial growth.
(8) It appears that the decline in plasma IGF-I lags considerably behind the sharp fall in plasma GH levels and expression of hepatic IGF-I mRNA.
(9) Supplementation of Mg resulted in a sharp increase in serum PTH level with a rapid disappearance of the dissociation between the two immunoassays of PTH.
(10) A.CA animals were extremely susceptible, showing a sharp and sustained increase in parasitemia starting on day 12, followed by death no later than day 15 post-inoculation.
(11) There was a sharp transition with actin nearly saturated with S1: when the S1 to actin ratio was low, the kinetics were fast (K1 greater than 300 microM, k2 greater than 40 s-1); when it was high, they were slow (K1 = 14 microM, k2 = 2 s-1).
(12) Low calcium causes an increase in optimum frequency, a decrease in current threshold, and an increase in sharpness of tuning in both real axons and axons computed according to the Hodgkin-Huxley formulation; high calcium causes opposite effects.
(13) The Tea Party movement has turned climate denial into a litmus test of conservative credentials – and that has made climate change one of the most sharp divisions between Obama and Romney.
(14) The presence in lamprey kidney of a loop which is similar to Henle's loop in mammals and birds indicates that the development of the system of osmotic concentration conditioned by the formation in the kidney of the medulla and from a sharp increase in renal arterial blood supply.
(15) There is no longer a sharp dividing line between working and rentiering.
(16) We are going to see a sharp fall unless sellers hold the sector up by making aggressive offers.
(17) A sharp increase in the intensity of lipids biochemiluminiscence and decrease in the tissue homogenates biochemiluminiscence were observed during the period of progressive tumour growth on the 6-8 days following introduction of the virus.
(18) By no means is this a new theme, but it has taken on an added sharpness and urgency after the conferences.
(19) The blood lymphocytes were small with scanty cytoplasm, densely condensed nuclear chromatin, and deep clefts originating in sharp angles from the nuclear surface.
(20) In sharp contrast, the coverage provided by the various mainstream news channels and newspapers not only seems – with some exceptions – unresponsive and stilted, but often non-existent.
Thick
Definition:
(superl.) Measuring in the third dimension other than length and breadth, or in general dimension other than length; -- said of a solid body; as, a timber seven inches thick.
(superl.) Having more depth or extent from one surface to its opposite than usual; not thin or slender; as, a thick plank; thick cloth; thick paper; thick neck.
(superl.) Dense; not thin; inspissated; as, thick vapors. Also used figuratively; as, thick darkness.
(superl.) Not transparent or clear; hence, turbid, muddy, or misty; as, the water of a river is apt to be thick after a rain.
(superl.) Abundant, close, or crowded in space; closely set; following in quick succession; frequently recurring.
(superl.) Not having due distinction of syllables, or good articulation; indistinct; as, a thick utterance.
(superl.) Deep; profound; as, thick sleep.
(superl.) Dull; not quick; as, thick of fearing.
(superl.) Intimate; very friendly; familiar.
(n.) The thickest part, or the time when anything is thickest.
(n.) A thicket; as, gloomy thicks.
(adv.) Frequently; fast; quick.
(adv.) Closely; as, a plat of ground thick sown.
(adv.) To a great depth, or to a greater depth than usual; as, land covered thick with manure.
(v. t. & i.) To thicken.
Example Sentences:
(1) The variation in thickness of the LLFL may modulate the species causing damage to the cells below it.
(2) An increase in membrane thickness was observed on phosphorylation.
(3) All patients with localized subaortic hypertrophy had left ventricular hypertrophy (left ventricular mass or posterior wall thickness greater than 2 SD from normal) with a normal size cavity due to aortic valve disease (2 patients were also hypertensive).
(4) Milk yield and litter weights were similar but backfat thickness (BF) was greater in 22 C sows (P less than .05) compared to 30 C sows.
(5) The enzyme was quantitated by incubation of 16-micron-thick brain sections with 0.07-2 nM of the converting enzyme inhibitor 125I-351A and comparison to 125I-standards.
(6) Grafts of intermediate thickness (M III) showed excellent clinical healing of the donor and the recipient site.
(7) At 7 days axonal swellings were infrequently observed and the main structural feature was a reduction in myelin thickness in affected nerve fibers.
(8) Suspensions of isolated insect flight muscle thick filaments were embedded in layers of vitreous ice and visualized in the electron microscope under liquid nitrogen conditions.
(9) The NAD-dependent enzymes (except alpha-GPDH) showed a stronger reactivity in the proximal tubules, while the NADP-dependent ones were more reactive in the thick limb of Henle's loop and distal convoluted tubules.
(10) In clinical situations on donor sites and grafted full-thickness burn wounds, the PEU film indeed prevented fluid accumulation and induced the formation of a "red" coagulum underneath.
(11) These early hyperplastic lesions revealed stellate-shaped dilated bile canaliculi lined by blebs and abnormally thick elongated microvilli, a decreased number of microvilli on the sinusoidal surface, a marked increase in smooth endoplasmic reticulum, large nucleoli, and bundles of pericanalicular microfilaments.
(12) The degree of overlap varies with the thickness of the arborization and is in the order of 1-2 mu.
(13) The spatial resolution of a NaI(T1), 25 mm thick bar detector designed for use in positron emission tomography has been studied.
(14) In the longitudinal direction, however, spatial resolution of under slice thickness could not be obtained.
(15) Thus, multiparae had very thick border zones composed predominantly of large nodules and, additionally, of vacuolated cells and fibrous tissue.
(16) The thickness of the media in the groups behaves like the number of nuclei: in hypertension with the highest values, there is no significant decrease as far as the 8th cross-section, while in the coronary sclerosis and third decade groups the values come closer together after the 6th cross-section.
(17) A model for left ventricular diastolic mechanics is formulated that takes into account noneligible wall thickness, incompressibility, finite deformation, nonlinear elastic effects, and the known fiber architecture of the ventricular wall.
(18) These force-generators are identified with projections (cross-bridges) on the thick filament, each consisting of part of a myosin molecule.
(19) Piretanide blocks the Na+ 2Cl- K+ cotransporter protein in the thick ascending limb (TAL) of the loop of Henle reversibly.
(20) Dioptric aniseikonia was calculated between 1 month and 24 months after surgery (with Gruber's and Huber's computer program) on the basis of most recently obtained values (bulb axis length, depth of the anterior chamber, lens thickness, necessary refraction), and compared with subjective measurements taken with the phase difference haploscope.