(1) In addition, congenital anemias such as sickle cell disease can impact on the health of the mother and fetus.
(2) Sickle and normal discocytes both showed membrane elasticity with reversion to original cell shape following release of the cell from its aspirated position at the pipette tip.
(3) Fourier transform infrared (FTIR) spectroscopy was used to examine the effect of oxysterol insertion into normal and sickle RBC membranes and the total lipid extracts of the membranes.
(4) The initial screening failed to detect sickle cell anemia in 4 infants, but the hemoglobinopathy in 3 of these infants was diagnosed correctly by routine retesting of those with suspected sickle cell trait.
(5) The sources were two adolescent patients with sickle cell disease and aplastic crisis who had unsuspected parvovirus infection.
(6) Thus, an abnormality of neutrophil oxidative metabolism cannot explain the propensity to bacterial infections in sickle cell disease.
(7) In order to examine sickle cell blood flow during MR imaging in vivo, laser-Doppler velocimetry was performed in normal control subjects and in sickle cell subjects before, during, and after MR imaging at 0.35 and 1.5 T. Mean blood flow and patterns of blood-flow variability were compared by two hematologists.
(8) Calcium-dependent ATPase, adenylate cyclase and phosphorylation of erythrocyte membrane proteins have been found abnormal in various conditions: hereditary spherocytosis, sickle-cell anemia, progressive muscular dystrophies, all of these disorders being associated with a decreased deformability of the erythrocyte.
(9) Sickle cell anemia and other hemoglobinopathies represent a major health problem in the United States.
(10) This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.
(11) We present a boy with sickle cell glomerulopathy and FSGS who is younger than patients with similar findings reported previously.
(12) Disruption of normal blood flow patterns in the medulla with impairment of function of the loop of Henle (functional papillectomy), presumably because of sickling in the hyperosmolar and anoxic environment of the renal medulla, may mediate these abnormalities.
(13) A study was conducted in a sample of 140 children with sickle cell anemia to evaluate the relationship between hematological variables (%HbF, %HbA2, %Hb, and mean cell volume) and disease severity.
(14) These include diseases diagnosed by restriction-site variation, such as Duchenne's muscular dystrophy and sickle cell anemia, those due to a collection of known mutations, such as beta-thalassemia, and those due to gene deletion, such as alpha-thalassemia.
(15) You’d think Michael Foot himself was running, attending debates in a hammer and sickle-print donkey jacket, from the amount we’ve been talking about him.
(16) Although these diseases are routinely screened for at birth, there is no general strategy among district health authorities for sickle cell screening.
(17) When red cells were loaded with Ca2+ using Ionophore A23187, both normal and sickle red cells enhanced their phosphorylation and sickle red cells to a greater extent than normal red cells.
(18) Nearly all sickle cell anemia patients carried the beta S mutation on a chromosome with haplotype 19 (or Benin) and all had severe anemia with sickling complications.
(19) The agent 12C79 which increases the oxygen affinity of sickle cells in vivo and prevent HbS polymerization is in clinical development.
(20) The results indicated that sickle cell patients have significant psychosocial distress in the areas of employment and finances, sleeping and eating, and performance of normal daily activities.
Sickler
Definition:
(n.) One who uses a sickle; a sickleman; a reaper.
Example Sentences:
(1) Clinical implications are discussed and the need for periodic assessment of auditory function in Nigeria sicklers for preventive management of auditory problems is emphasized.
(2) These data suggest a decrease or lack of intravascular volume expansion and evidence of uteroplacental insufficiency in sicklers.
(3) The above findings are discussed in relation to the other complications of sickler cell disease in other organs of the body.
(4) We also found plasma fibrinogen concentration in sicklers to be about twice as high as that of normals.
(5) The probable explanations were the high prevalence of fetal haemoglobin in Arab sicklers, the rarity of sickle cell disease among the Arabs and the possible existence of a different gene.
(6) High rouleaux formation in sicklers could be attributed not only to fibrinogen and other plasma factors but also to cellular factors.
(7) Non-sicklers of similar ages and with similar temperatures were also studied as controls.
(8) The significance of these results are discussed and the need for establishing the sensitivity of the infecting organism in every case and for early surgical exploration in non-sicklers are stressed.
(9) The extent of tissue damage caused by vaso-occlusion in sickle cell disease in those organs rich in acid phosphatase was assessed by measuring serum acid phosphatase in 33 patients with homozygous sickle cell disease Hb-SS (sicklers) and comparing the result with that of 31 persons with normal haemoglobin-AA (non-sicklers) matched for age and sex.
(10) Blood was collected from HbSS-confirmed sicklers (80 males and 75 females, age 2-26 and 1-27 years, respectively) who attended our clinics.
(11) Eighty three of the subjects were sickle-cell anaemia patients (sicklers) with haemoglobin genotype HbSS, and in the steady state; 30 were subjects who had the sickle-cell trait (HbAS), and 55 were subjects with the normal haemoglobin genotype HbAA.
(12) However, a national collaborative randomized study is needed to adequately address the controversy regarding the use of red cell exchange in the pregnant sickler.
(13) The result showed a decrease in the level of total, labile and tartrate-resistant serum acid phosphatase in sicklers compared to non-sicklers, though the decrease is not statistically significant (p greater than 0.1).
(14) The erythrocyte sialic acid concentration was significantly (P less than 0.001) higher in sickle-cell patients than in non-sicklers and although the concentration was higher in AS than AA individuals the difference was not significant (P greater than 0.05).
(15) In view of the aesthetic and medical implications of these abnormalities, it is recommended that sicklers should receive regular dental check-up with a view to ameliorating or preventing these complications by prophylactic measures including the use of orthodontic appliances such as braces, etc.
(16) From a sample of 1,079 male adult Zairians living in regions where falciparum malaria is endemic 212 sicklers and 867 nonsicklers were compared for eight anthropometric variables.
(17) The levels of ELT and FDP were significantly higher in sicklers in steady state than non-sicklers, but significantly lowered in sicklers in crisis than both non-sicklers and sicklers in stable state.
(18) By using a non-invasive Doppler technique, vessel compliance (C) was measured in the aorta, iliac and leg arterial segments of 25 juvenile and adult-onset diabetics of recent diagnosis and also in seven sickle-cell subjects (sicklers) whose conditions were known to have reached crisis state.
(19) The results were compared between those subjects who encountered more frequent vaso-occlusive crisis episodes (frequent sicklers) and those with fewer crisis episodes (infrequent sicklers), along with parameters between crisis and non-crisis states of frequent sicklers.
(20) The sicklers and non-sicklers (control group) did not show any significant differences in the pattern of tympanograms, static middle ear compliance and mean acoustic reflex thresholds, suggesting essentially normal middle ear mechanisms in both groups.