(1) And we welcome the new minister of women's affairs, Doctor Sima Samar.
(2) A mucin preparation from a colonic adenocarcinoma was used to prepare monoclonal antibodies (MAbs) that reacted specifically either with normal adult small-intestine mucin antigen(s) (SIMA), or normal adult large-intestine mucin antigen(s) (LIMA).
(3) Only the SIMA epitope was sensitive to neuraminidase.
(4) In the BIMA group two pleural cavities, the SIMA group one pleural sac and the VS group none of the pleural cavities was entered.
(5) At the subcellular level, both anti-SIMA MAb showed reactivity typical of normal mucin, i.e., goblet cell and extracellular mucin.
(6) SIMA epitopes are thus markers of very early neoplastic change, whose expression correlates with malignant potential and may contribute to the accumulation of changes necessary for tumourigenesis.
(7) Inappropriate SIMA production was detected by either anti-SIMA MAb 4D3 or 4A1, even in 85% of early stage cancers.
(8) Inappropriate expression of SIMA epitopes was first detected in mucosa adjacent to minute microadenomas larger than three glands, and with increase in size, in increasing amounts within adenomas themselves, but not with microadenomas smaller than three glands or regions of flat mucosa free of adenomas.
(9) Comparison of the pre-operative data showed that patients who had a SIMA were similar to those who had a SVG except that they were older, had a more stable presentation and they had a higher incidence of myocardial infarction.
(10) We describe the production, immunochemical and immunohistochemical characterization of monoclonal antibodies (MAbs) raised against the oncofetal small intestinal mucin antigen (SIMA).
(11) A high rate of inappropriate SIMA expression was also detected in the perineoplastic transitional mucosa (88%, c.f.
(12) The previously reported hierarchy of four SIMA epitopes (5C5, 3D4, 4D3, 6C5) was also consistently observed in the adenoma-carcinoma sequence, and applied to (i) the order of epitope detection, (ii) the number of positive adenomas and (iii) extent of staining; (iv) the height in the crypt and (v) distance from the adenoma to which epitopes were expressed in perineoplastic mucosa.
(13) The colorectal adenoma-carcinoma sequence was examined in relation to the ectopic expression of the oncofoetal Small Intestinal Mucin Antigen (SIMA), to the development of morphologic changes in the adenoma and perineoplastic mucosa and to indices of malignant potential.
(14) The percentage of positive adenomas and reactivity scores for each anti-SIMA MAb correlated with increasing adenoma size, degree of dysplasia and growth pattern.
(15) Photograph: Sima Diab for the Guardian This article was amended on 22 June 2015 to change the description of Hungary’s government to “illiberal” to better reflect the regime in place.
(16) Photograph: Sima Diab for the Guardian While they wait for his call, everyone fears an attack from the police.
(17) Photograph: Sima Diab for the Guardian As the sun sets, huddle after huddle of Syrian refugees, travelling together for protection, edge north along the bends of the river.
(18) Small intestine mucin antigen (SIMA) is an oncofoetal antigen for the colon and is distinct from the normal large intestinal mucin antigen (LIMA).
(19) SIMA epitope expressed in mucosa adjacent to adenomas preceded changes in perineoplastic morphology, which progressed with adenoma growth to resemble transitional mucosa (TM) adjacent to cancers.
(20) In the control and gastric carcinoma groups, neither large intestinal mucin antigen (LIMA) nor small intestinal mucin antigen (SIMA) could be detected in the normal epithelium of gastric mucosa.
Simar
Definition:
(n.) A woman's long dress or robe; also light covering; a scarf.