(1) These factors are also associated with multiple endocrinological neoplasms type II of Sipple's syndrome.
(2) In a case of familial Sipple disease, follicular lining cells were replaced in areas with ACTH-containing cells.
(3) We recommend the calcium infusion test for: (a) screening for MCT in all Sipple relatives with normal or only slightly elevated basal S-CT, (b) postoperative control in both sporadic and hereditary MCT, (c) investigation of supposed non-MCT tumours with calcitonin production.
(4) Particular attention is drawn to two cases with bilateral sites (one male child, one woman with Sipple's syndrome) and the detection of possible local and distant malignancy.
(5) One hundred and fourteen cases of Sipple's syndrome have been reported in Japan.
(6) MCT would thus appear to be more frequently visualized by MIBG in cases of Sipple's syndrome than in sporadic cases.
(7) Sipple's syndrome (bilateral phaeochromocytoma and medullary thyroid carcinoma) is a multiple endocrinopathy with a familial occurrence.
(8) Approximately twice as often an isolated variant of the familial type of medullary carcinoma is involved, as compared with association with another endocrine affection, in particular pheochromocytoma (Sipple's syndrome), but associated forms will increase in number perspectively (multiple endocrine neoplasia 2A).
(9) Whether this is due to a real geographical variation of incidence, to a larger number of unreported cases in the Northern parts, or to presence of families with Sipple's syndrome in the South is unclear.
(10) Extensive studies revealed that the patient was suffering from a multiple endocrine neoplasia syndrome (type 2A or Sipple's syndrome) with bilateral pheochromocytomas and a medullary thyroid carcinoma.
(11) Of the multiple endocrine syndromes, the association between pheocromochytoma, medullary thyroid carcinoma (MTC) and parathyroid-hyperplasia (Sipple's syndrome, MEN IIa), and the association of MTC, with multiple monocutaneous neuromas and with a characteristic facial appearance (MEN IIb syndrome) are well known.
(12) In our opinion MR may replace both CT and nuclear scans in the work up of Sipple disease.
(13) Twenty-nine patients had the familial form of MTC; they were subclassified, on the basis of the phenotype, into a group of 15 patients with Sipple syndrome (or multiple endocrine neoplasia (MEN) Type 2A) and a group of 14 patients with mucosal-neuroma phenotype (or MEN type 2B).
(14) Although an exact reason for this remained unknown, our data could suggest that the adrenal tumors in Sipple's syndrome are primarily different from other types of pheochromocytoma, and thorough examinations for detecting the thyroid carcinoma should be necessary when the adrenal tumor is rich in epinephrine.
(15) This calcium infusion test was used in a prospective screening for medullary carcinoma of the thyroid (MCT) in 4 families with Sipple's syndrome as well as in 3 sporadic cases of MCT.
(16) Our patient had a strong family history for Sipple syndrome, which is considered to be transmitted as an autosomal dominant.
(17) However, such other symptoms of Sipple syndrome as presence of endocrine tumors are absent.
(18) This case report describes the localization and categorization of tumors using 99mTc(V)-dimercaptosuccinic acid and [131I]metaiodobenzylguanidine scans in a very uncommon case of medullary thyroid carcinoma associated with pheochromocytoma (Sipple's syndrome) and hepatocellular carcinoma.
(19) This study deals with 11 cases of thyroid medullary carcinoma of which 7 were familial cases including 3 cases of Sipple's syndrome and 4 cases of sporadic cases.
(20) A parallel between this situation and Sipple's disease in humans has previously been suggested.
Stipple
Definition:
(v. t.) To engrave by means of dots, in distinction from engraving in lines.
(v. t.) To paint, as in water colors, by small, short touches which together produce an even or softly graded surface.
(n.) Alt. of Stippling
Example Sentences:
(1) There was a 25-year history of normochromic normocytic anaemia with moderate basophilic stippling, mild renal failure, hyperuricaemia and abnormal porphyrins.
(2) Basophilic stippling and circulating nucleated red cells were not common findings in blood films.
(3) All of the cases exibited the classic form of osteopoikilosis with stippling.
(4) Seven of 100 (three bilateral, four unilateral) patients demonstrated rib stippling.
(5) We observed various macular pathologies in the form of macular stippling, retinal pigment epithelial defects, colloids & disciform lesions all in NIDDM patients, 70% of whom were uncontrolled on therapy.
(6) A distinct stippled pattern of vascular fluorescence was found in 87% of lesion biopsies; 75% of these contained deposits of IgA.
(7) We assumed, therefore, that there are two different ultrastructural forms of 3H-tryptophan containing extracellular enamel proteins and suggest that the granular or "stippled" form represents newly secreted precursor enamel protein.
(8) The "experimental" morphologic criteria were the presence of both basophilic stippling and either microcytosis or target cells.
(9) The calcification of the involved joints was more diffuse than the usual linear stippled calcification.
(10) The fish exposed to the highest lead concentration also showed an anemic response and basophilic stippling of erythrocytes.
(11) The second was a 16 months old Arabic boy without typical features but with a cataract and stippled calfications of a limited number of epiphysae.
(12) The neoplastic lymphoid cells consisted of either a monomorphous population or a variable mixture of small, medium-sized, and large cells with stippled chromatin and distinct nucleoli.
(13) In preameloblasts, on the other hand, the precipitates were located in mitochondria, nuclei, and on the inner face of the plasma membrane; however, few reaction products were observed in the intercellular spaces, lysosomelike granules, secretory granules, and stippled materials.
(14) Since the majority of transitional cell neoplasms have a papillary configuration, the stipple sign is highly suggestive of the presence of this lesion.
(15) In all three eyes, characteristic "stippling," or granularity, of the affected macula developed rapidly and vitreal cells were observed.
(16) Upon microscopic examination, any vaginal discharge with epithelial cells stippled with small coccobacilli indicated a possible Gardnerella vaginalis infection.
(17) To evaluate the mechanical or biochemical insult to the cornea induced by overnight rigid gas permeable (RGP) or soft contact lens (SCL) wear, punctate, stipple staining and corneal blotting were evaluated by biomicroscopy in a group of 23 subjects who participated in a single overnight in-laboratory test session.
(18) Fan-shaped stippled burns were produced on the skin when a revolver whose barrel had been modified by the Mag-Na-Port process was fired twice with the side of the muzzle in contact.
(19) The phalangeal anomaly is very important for the diagnosis of chondrodysplasia punctata at an age when epiphyseal stippling is no longer present.
(20) On computed tomographic scanning, an iso-or high-density mass containing stippled calcifications and originating in a posterior cervical neural arch was observed in all three cases.