(1) These factors are also associated with multiple endocrinological neoplasms type II of Sipple's syndrome.
(2) In a case of familial Sipple disease, follicular lining cells were replaced in areas with ACTH-containing cells.
(3) We recommend the calcium infusion test for: (a) screening for MCT in all Sipple relatives with normal or only slightly elevated basal S-CT, (b) postoperative control in both sporadic and hereditary MCT, (c) investigation of supposed non-MCT tumours with calcitonin production.
(4) Particular attention is drawn to two cases with bilateral sites (one male child, one woman with Sipple's syndrome) and the detection of possible local and distant malignancy.
(5) One hundred and fourteen cases of Sipple's syndrome have been reported in Japan.
(6) MCT would thus appear to be more frequently visualized by MIBG in cases of Sipple's syndrome than in sporadic cases.
(7) Sipple's syndrome (bilateral phaeochromocytoma and medullary thyroid carcinoma) is a multiple endocrinopathy with a familial occurrence.
(8) Approximately twice as often an isolated variant of the familial type of medullary carcinoma is involved, as compared with association with another endocrine affection, in particular pheochromocytoma (Sipple's syndrome), but associated forms will increase in number perspectively (multiple endocrine neoplasia 2A).
(9) Whether this is due to a real geographical variation of incidence, to a larger number of unreported cases in the Northern parts, or to presence of families with Sipple's syndrome in the South is unclear.
(10) Extensive studies revealed that the patient was suffering from a multiple endocrine neoplasia syndrome (type 2A or Sipple's syndrome) with bilateral pheochromocytomas and a medullary thyroid carcinoma.
(11) Of the multiple endocrine syndromes, the association between pheocromochytoma, medullary thyroid carcinoma (MTC) and parathyroid-hyperplasia (Sipple's syndrome, MEN IIa), and the association of MTC, with multiple monocutaneous neuromas and with a characteristic facial appearance (MEN IIb syndrome) are well known.
(12) In our opinion MR may replace both CT and nuclear scans in the work up of Sipple disease.
(13) Twenty-nine patients had the familial form of MTC; they were subclassified, on the basis of the phenotype, into a group of 15 patients with Sipple syndrome (or multiple endocrine neoplasia (MEN) Type 2A) and a group of 14 patients with mucosal-neuroma phenotype (or MEN type 2B).
(14) Although an exact reason for this remained unknown, our data could suggest that the adrenal tumors in Sipple's syndrome are primarily different from other types of pheochromocytoma, and thorough examinations for detecting the thyroid carcinoma should be necessary when the adrenal tumor is rich in epinephrine.
(15) This calcium infusion test was used in a prospective screening for medullary carcinoma of the thyroid (MCT) in 4 families with Sipple's syndrome as well as in 3 sporadic cases of MCT.
(16) Our patient had a strong family history for Sipple syndrome, which is considered to be transmitted as an autosomal dominant.
(17) However, such other symptoms of Sipple syndrome as presence of endocrine tumors are absent.
(18) This case report describes the localization and categorization of tumors using 99mTc(V)-dimercaptosuccinic acid and [131I]metaiodobenzylguanidine scans in a very uncommon case of medullary thyroid carcinoma associated with pheochromocytoma (Sipple's syndrome) and hepatocellular carcinoma.
(19) This study deals with 11 cases of thyroid medullary carcinoma of which 7 were familial cases including 3 cases of Sipple's syndrome and 4 cases of sporadic cases.
(20) A parallel between this situation and Sipple's disease in humans has previously been suggested.
(a.) Yielding compliant; not obstinate; submissive to guidance; as, a supple horse.
(a.) Bending to the humor of others; flattering; fawning; obsequious.
(v. t.) To make soft and pliant; to render flexible; as, to supple leather.
(v. t.) To make compliant, submissive, or obedient.
(v. i.) To become soft and pliant.
Example Sentences:
(1) (Acta Chir Scand [Suppl] 346:1-12, 1965) was determined.
(2) Children as young as 18 months start by sliding on tiny skis in soft supple boots, while over-threes have more formal lessons in the snow playground.
(3) Ultrastructural studies of Aeromonas hydrophila strain AH26 revealed two distinctive pilus types: "straight" pili appear as brittle, rod-like filaments, whereas "flexible" pili are supple and curvilinear.
(4) Priestman (Eur J Cancer Clin Oncol 25:529-533, 1989 [Suppl]) reported on a pilot and randomized study with ondansetron after single doses of 8 to 10 Gy to the upper abdomen.
(5) 11 (suppl 14) 331 (abstract)] [14] also indicates that sensitivity to 4-HC can be used to distinguish primitive progenitor cells from committed progenitor cells.
(6) Large-scale clinical trials have established that lowering blood pressure in patients with mild to moderate diastolic hypertension results in a decreased incidence of stroke and, to a lesser extent, a reduction in incidence of coronary heart disease [MacMahon SW, Cutler JA, Furberg CD, et al: Prog Cardiovasc Dis 1986; 29 (suppl 1): 99-118].
(7) We have used either superior or inferior flaps but over the last 25 years we have preferred the latter type of flap (Rosenthal) which produces better results because: 1) it is retracted laterally to a lesser degree, 2) it is more supple, 3) it is attached below and posteriorly to the soft palate (which permits the pharyngeal constrictor muscles, during contraction, to apply pressure against the lateral borders of the flap, and thus avoid any nasal regurgitation).
(8) "When you're inside an idea it's hard to think of it as ambitious, but yes it is a huge mountain we are climbing, it's a huge sea we are crossing," said Supple.
(9) Wide subperiosteal undermining in primary surgical correction of labio-maxillary clefts not only enhances the osteogenic activity of the periosteum but in addition, if the exposure is extended from the superior limit of the ascending maxillary process and the nasal bone to the inferior orbital rim above the infra-orbital foramen and the malar eminence, good suppleness of the overlying muscles can be achieved.
(10) The authors observed an abnormal frequency of laryngo-tracheal stenosis over a period of three months, corresponding to the use of a defective lot of supple catheters for single use and made of polyvinyl chloride.
(11) Muscarine has been iso lared in a yield of 0.013 percent from mycelia of Clitocybe rivulosa grown in the laboratory on a medium supple mented with beer wort.
(12) One may thus carry out by an extremely benign operation without any mortality, a surgical cure not only of supple stenoses, but also of certain tight fibrous stenoses, considered insuperable.
(13) The second stage of the reeducation concerns the tongue moving tonicity and suppleness.
(14) This flap provides thin, supple skin for reconstruction of moderately sized vaginal defects leaving a minimal donor defect.
(15) Preoperative requirements include a well-motivated patient with a supple digit and an established wide discrepancy between the active and passive ranges of digital motion.
(16) Microscopic normalization of the actinically damaged epidermis and papillary dermis was manifested clinically by the replacement of dermatoheliosis with supple, smooth-textured facial skin that remained clinically evident well beyond 8 years after dermabrasion.
(17) Speedy postpartum weight loss isn't just for celebs In Karnataka, southern India, older women in the community who care for new mothers urge them to become thinner than they were before pregnancy, "like the tip of a mantani leaf – thin, slender, fresh and supple," says Dr Saraswathy Ganapathy of the Belaku Trust , which works to improve the lives of women in the area.
(18) Suppl 2 decreased plasma triglycerides, further increased the RBC alpha-tocopherol, moderately increased the RBC double-bond index, but decreased the RBC total fatty acid-cholesterol ratio.
(19) He tests the suppleness of his editing muscles by running a clip of film, noting where the actor blinks, then re-playing and halting at exactly that frame (there's 24 of them a second).
(20) LBA was done using a supple balloon catheter (LBA-c) which was placed blind down the intubation tube, until a distal bronchus was blocked (under radiographic control).