(1) These factors are also associated with multiple endocrinological neoplasms type II of Sipple's syndrome.
(2) In a case of familial Sipple disease, follicular lining cells were replaced in areas with ACTH-containing cells.
(3) We recommend the calcium infusion test for: (a) screening for MCT in all Sipple relatives with normal or only slightly elevated basal S-CT, (b) postoperative control in both sporadic and hereditary MCT, (c) investigation of supposed non-MCT tumours with calcitonin production.
(4) Particular attention is drawn to two cases with bilateral sites (one male child, one woman with Sipple's syndrome) and the detection of possible local and distant malignancy.
(5) One hundred and fourteen cases of Sipple's syndrome have been reported in Japan.
(6) MCT would thus appear to be more frequently visualized by MIBG in cases of Sipple's syndrome than in sporadic cases.
(7) Sipple's syndrome (bilateral phaeochromocytoma and medullary thyroid carcinoma) is a multiple endocrinopathy with a familial occurrence.
(8) Approximately twice as often an isolated variant of the familial type of medullary carcinoma is involved, as compared with association with another endocrine affection, in particular pheochromocytoma (Sipple's syndrome), but associated forms will increase in number perspectively (multiple endocrine neoplasia 2A).
(9) Whether this is due to a real geographical variation of incidence, to a larger number of unreported cases in the Northern parts, or to presence of families with Sipple's syndrome in the South is unclear.
(10) Extensive studies revealed that the patient was suffering from a multiple endocrine neoplasia syndrome (type 2A or Sipple's syndrome) with bilateral pheochromocytomas and a medullary thyroid carcinoma.
(11) Of the multiple endocrine syndromes, the association between pheocromochytoma, medullary thyroid carcinoma (MTC) and parathyroid-hyperplasia (Sipple's syndrome, MEN IIa), and the association of MTC, with multiple monocutaneous neuromas and with a characteristic facial appearance (MEN IIb syndrome) are well known.
(12) In our opinion MR may replace both CT and nuclear scans in the work up of Sipple disease.
(13) Twenty-nine patients had the familial form of MTC; they were subclassified, on the basis of the phenotype, into a group of 15 patients with Sipple syndrome (or multiple endocrine neoplasia (MEN) Type 2A) and a group of 14 patients with mucosal-neuroma phenotype (or MEN type 2B).
(14) Although an exact reason for this remained unknown, our data could suggest that the adrenal tumors in Sipple's syndrome are primarily different from other types of pheochromocytoma, and thorough examinations for detecting the thyroid carcinoma should be necessary when the adrenal tumor is rich in epinephrine.
(15) This calcium infusion test was used in a prospective screening for medullary carcinoma of the thyroid (MCT) in 4 families with Sipple's syndrome as well as in 3 sporadic cases of MCT.
(16) Our patient had a strong family history for Sipple syndrome, which is considered to be transmitted as an autosomal dominant.
(17) However, such other symptoms of Sipple syndrome as presence of endocrine tumors are absent.
(18) This case report describes the localization and categorization of tumors using 99mTc(V)-dimercaptosuccinic acid and [131I]metaiodobenzylguanidine scans in a very uncommon case of medullary thyroid carcinoma associated with pheochromocytoma (Sipple's syndrome) and hepatocellular carcinoma.
(19) This study deals with 11 cases of thyroid medullary carcinoma of which 7 were familial cases including 3 cases of Sipple's syndrome and 4 cases of sporadic cases.
(20) A parallel between this situation and Sipple's disease in humans has previously been suggested.
Tipple
Definition:
(v. i.) To drink spirituous or strong liquors habitually; to indulge in the frequent and improper used of spirituous liquors; especially, to drink frequently in small quantities, but without absolute drunkeness.
(v. t.) To drink, as strong liquors, frequently or in excess.
(v. t.) To put up in bundles in order to dry, as hay.
(n.) Liquor taken in tippling; drink.
Example Sentences:
(1) Everyone knows that Father Christmas’s tipple of choice is brandy, so Santa, if you’re reading this, we recommend you pause in The Flask on Highgate West Hill for a quick snifter.
(2) They’re cracking open the baijiu ,” said John Delury, a China expert from Yonsei University in Seoul, referring to China’s throat-scorching national tipple.
(3) Since Chlamydia trachomatis was isolated from middle ear effusions of neonates with natally acquired chlamydial infection (Tipple et al., 1979), there have been several studies to detect chlamydia in older children with chronic secretory otitis media, mainly by tissue culture.
(4) The taoiseach promised that he would open it up and enjoy a tipple on the day Ireland exited the IMF-EU bailout .
(5) The British gin industry had a record-breaking year in 2015 after 49 new distilleries opened their doors and and consumers spent nearly £1bn on their favourite tipple.
(6) A study earlier this year on the wine ingredient resveratrol now suggests the tipple may not hold the secret of why countries such as France have such a low incidence of heart disease.
(7) Mocotó is also a cachaçaria , selling more than 500 cachaças – a tipple often associated with poor people and drunks – from all over the country.
(8) Good news, obviously, but isn't Baileys a bit of a, well, girls' tipple?
(9) Describing the whisky duty freeze as Osborne's "referendum tipple," Swinney said: "The £63m added to the Scottish budget today is small beer compared to the significant cuts Scotland has faced since 2010.
(10) The trend has been attributed to factors including pub prices comparing unfavourably with the cost of alcohol in supermarkets and changing cultural habits, with more people entertaining and sharing a tipple at home.
(11) Photograph: PR The forward galley’s catering facilities have wine glasses for an in-flight tipple while the bathroom includes a shower and a vacuum lavatory.
(12) On the day his death was announced, Hardee's friends and family converged on the Wibbly Wobbly to pour a measure of his favourite tipple, rum and Coke, into the river where he felt so at home.
(13) Order a flight of pisco (from £3.45) or a round of pisco sours (from £3.25 each) and decide for yourself which country’s tipple tickles your fancy.
(14) My tipple was mostly white wine, and I probably drank, on average, a bottle a night – more at the weekends.
(15) Basque wine or cider are the classic tipples, but Atari also mixes killer gin and tonics.
(16) But after word spread about her sake venture, Sasaki quickly found herself running out of stock as old neighbours and new customers indulged their love of her cloudy, slightly fizzy tipple.
(17) Californian online retailer Wines that Rock, responsible for the Rolling Stones' Forty Licks Merlot and Pink Floyd's The Dark Side of the Moon Cabernet Sauvignon, has collaborated with a Bordeaux vineyard to develop a tipple giving a nod to the clarets favoured by the English aristocracy in the Edwardian era.
(18) "No regrets," she asserts haughtily, knocking back a glass of rakija , the local tipple.
(19) But you might want to try another tipple after hearing the case of a 47-year-old woman, published in the New England Journal of Medicine (NEJM), who developed brittle bones and lost all of her teeth after drinking too much tea .
(20) It was the working man’s tipple and in the early 20th century there were more than 1,000 pulquerías in Mexico City.