(n.) A man of social authority and dignity; a lord; a master; a gentleman; -- in this sense usually spelled sire.
(n.) A title prefixed to the Christian name of a knight or a baronet.
(n.) An English rendering of the LAtin Dominus, the academical title of a bachelor of arts; -- formerly colloquially, and sometimes contemptuously, applied to the clergy.
(n.) A respectful title, used in addressing a man, without being prefixed to his name; -- used especially in speaking to elders or superiors; sometimes, also, used in the way of emphatic formality.
(1) Businesses fleeing Brexit will head to New York not EU, warns LSE chief Read more Amid attempts by Frankfurt, Paris and Dublin to catch possible fallout from London, Sir Jon Cunliffe said it was highly unlikely that any EU centre could replicate the services offered by the UK’s financial services industry.
(2) However the imagery is more complex, because scholars believe it also relates to another cherished pre-Raphaelite Arthurian legend, Sir Degrevaunt who married his mortal enemy's daughter.
(3) At the moment the MPA makes the appointments in consultation with the Met commissioner, Sir Paul Stephenson.
(4) It has also been given to Sir Andrew Large, a former deputy governor of the Bank of England, whose report on lending failures by RBS will also be released on Monday.
(5) There on the street is Young Jo whose last words were, "I am wery symbolic, sir."
(6) It will form part of an investigation launched by the cabinet secretary, Sir Jeremy Heywood, on the orders of David Cameron to determine the British government's actions over the raid on Sikhism's holiest site in Amritsar.
(7) Sir James Crosby, the ITV senior independent non-executive director, explained why the board had opted to retain Grade's services for an extra year: "It was the unanimous view of ITV's independent non-executive directors that it would be in the best interests of the company and its shareholders to ask Michael to extend his time as executive chairman.
(8) Updated at 1.58pm BST 12.43pm BST Sir Malcolm Bruce, MP for Gordon, says there has been "a degree of intransigence" on both sides at Grangemouth, leading to today's closure.
(9) At a private meeting last Tuesday, Hunt assured Cameron and the cabinet secretary, Sir Jeremy Heywood, that he had not been aware that his special adviser, Adam Smith, was systematically leaking information and advice to News Corp about its bid for BSkyB.
(10) Yesterday streams of worshippers and tourists entered Sir Christopher Wren's building for Sunday services, apparently unconcerned by events outside.
(11) With respect to Sir Jimmy, those who proclaim the age of the train rarely get it right.
(12) The Dacre review panel, which included Sir Joseph Pilling, a retired senior civil servant, and the historian Prof Sir David Cannadine, said Britain now had one of the "less liberal" regimes in Europe for access to confidential government papers and that reform was needed to restore some trust between politicians and people.
(13) Facebook Twitter Pinterest Whether Sia, Jason Derulo, Coldplay’s Chris Martin or Sir Elton John is in the passenger seat, Corden plays the part of a real fan with a deep knowledge of their discography.
(14) We have the president of the tribunal, Sir Michael Burton, arguing that his work needs to be done in secret to secure the trust and co-operation of the intelligence services – but what about the trust of the British people and the confidence of the lawyers who seek to establish the rights of ordinary members of the public?
(15) The four members of the committee are all masters of wine, and the chairman is a retired diplomat, Sir David Wright.
(16) The validity of the response of this probe to Y-90 and its clinical application were assessed with a phantom containing varying activities and with biopsy samples obtained from patients being treated with SIR therapy.
(17) Sir James Crosby, the chief executive until 2006, was forced to resign as deputy chairman of the Financial Services Authority after the Treasury select committee produced allegations by a whistleblower that the bank was "going too fast".
(18) Leading figures including the musician Sting, business tycoon Sir Richard Branson and comedian Russell Brand have called for the possession of drugs to be decriminalised.
(19) Sir Philip Green has interesting tax arrangements but far from being labelled morally repugnant in a Mexico TV studio, he has got a government review to head up," she said.
(20) When last week’s scandal broke, Tesco chair Sir Richard Broadbent airily opined: “Things are always unnoticed until they are noticed.” He forgot to mention that that goes double if people are paid to turn a blind eye.
(n.) A colloquial abbreviation of Sister.
(n.) Six. See Sise.
(1) Chromatographic separation revealed that the bulk (85%) of the mitogenic activity in SSV-transformed NRK cells was not due to p28v-sis but rather two distinct endothelial cell growth factors that eluted off heparin-Sepharose between 1 and 2 M NaCl.
(2) To get an insight into the nature of variant Ph translocations and the process of their formation, we examined the localization of the c-abl and c-sis oncogenes and the breakpoint cluster region (bcr) gene by chromosomal in situ hybridization in ten variant Ph translocations of CML including five simple and five complex ones as initially interpreted.
(3) Loss of a c-sis allele (allele I in all cases) was observed in 6 out of 10 tumors from heterozygous patients.
(4) Cells transformed by v-sis produce a platelet-derived growth factor-related molecule which is able to stimulate the platelet-derived growth factor receptor in an autocrine fashion.
(5) The v-sis oncogene of simian sarcoma virus (SSV) is a retroviral version of the PDGF B chain gene and SSV-transformation is mediated by an autocrine PDGF-like growth factor.
(6) Messenger RNA levels for v-sis were induced by tension in intact but not denuded vessels.
(7) In both loci, similar unique genetic sequences were found upstream of the v-sis homologous region and these hybridized to a 4.2 kbp c-sis transcript in human lung tumor cells.
(8) First, we investigated the expression of c-sis protooncogenes within cultured human glioma cell lines and also fresh glioma specimens by using polymerase chain reaction.
(9) The v-sis gene encodes chain B of platelet-derived growth factor.
(10) However, in tissue adjacent to 5 different tumors, approximately the same level of c-sis mRNA was seen.
(11) c-sis mRNA levels diminished with increased time of infection.
(12) For example, platelet-derived growth factor (PDGF) has been found in many normal tissues including the CNS, while minor changes in one of its forms (PDGF-B) converts it to the v-sis oncogene, capable of inducing sarcomas and astrocytomas in primates.
(13) SIS SVB was performed to a variety of vessel combinations using "Y" graft, continuous, or vein extension techniques achieving early patency in all limbs, despite pedal arch disease.
(14) Radiolabeled recombinant PDGF (c-sis) dissociated from Heparin-Sepharose within a concentration range of NaCl similar to that of RF I.
(15) increased cell size, reduced growth rate, megakaryocytic antigens, and expression of the sis proto-oncogene, the structural gene for the B-chain of platelet-derived growth factor.
(16) In human malignant mesothelioma cell lines elevated expression of the platelet-derived growth factor (PDGF) beta-chain (c-sis) gene was previously reported, while normal mesothelial cells barely express this gene.
(17) The same temporal dissociation was observed when a recombinant v-sis product was used instead of porcine PDGF.
(18) Reduced function of runt results in female-specific lethality and sexual transformation of XX animals that are heterozygous for Sxl or sis loss-of-function mutations.
(19) Several specific related questions are addressed in this discussion: Is the protein encoded by the v-sis gene functionally identical to PDGF?
(20) This suggests that H-ras is less efficient in relieving the insulin requirement than is sis.