(1) Chromatographic separation revealed that the bulk (85%) of the mitogenic activity in SSV-transformed NRK cells was not due to p28v-sis but rather two distinct endothelial cell growth factors that eluted off heparin-Sepharose between 1 and 2 M NaCl.
(2) To get an insight into the nature of variant Ph translocations and the process of their formation, we examined the localization of the c-abl and c-sis oncogenes and the breakpoint cluster region (bcr) gene by chromosomal in situ hybridization in ten variant Ph translocations of CML including five simple and five complex ones as initially interpreted.
(3) Loss of a c-sis allele (allele I in all cases) was observed in 6 out of 10 tumors from heterozygous patients.
(4) Cells transformed by v-sis produce a platelet-derived growth factor-related molecule which is able to stimulate the platelet-derived growth factor receptor in an autocrine fashion.
(5) The v-sis oncogene of simian sarcoma virus (SSV) is a retroviral version of the PDGF B chain gene and SSV-transformation is mediated by an autocrine PDGF-like growth factor.
(6) Messenger RNA levels for v-sis were induced by tension in intact but not denuded vessels.
(7) In both loci, similar unique genetic sequences were found upstream of the v-sis homologous region and these hybridized to a 4.2 kbp c-sis transcript in human lung tumor cells.
(8) First, we investigated the expression of c-sis protooncogenes within cultured human glioma cell lines and also fresh glioma specimens by using polymerase chain reaction.
(9) The v-sis gene encodes chain B of platelet-derived growth factor.
(10) However, in tissue adjacent to 5 different tumors, approximately the same level of c-sis mRNA was seen.
(11) c-sis mRNA levels diminished with increased time of infection.
(12) For example, platelet-derived growth factor (PDGF) has been found in many normal tissues including the CNS, while minor changes in one of its forms (PDGF-B) converts it to the v-sis oncogene, capable of inducing sarcomas and astrocytomas in primates.
(13) SIS SVB was performed to a variety of vessel combinations using "Y" graft, continuous, or vein extension techniques achieving early patency in all limbs, despite pedal arch disease.
(14) Radiolabeled recombinant PDGF (c-sis) dissociated from Heparin-Sepharose within a concentration range of NaCl similar to that of RF I.
(15) increased cell size, reduced growth rate, megakaryocytic antigens, and expression of the sis proto-oncogene, the structural gene for the B-chain of platelet-derived growth factor.
(16) In human malignant mesothelioma cell lines elevated expression of the platelet-derived growth factor (PDGF) beta-chain (c-sis) gene was previously reported, while normal mesothelial cells barely express this gene.
(17) The same temporal dissociation was observed when a recombinant v-sis product was used instead of porcine PDGF.
(18) Reduced function of runt results in female-specific lethality and sexual transformation of XX animals that are heterozygous for Sxl or sis loss-of-function mutations.
(19) Several specific related questions are addressed in this discussion: Is the protein encoded by the v-sis gene functionally identical to PDGF?
(20) This suggests that H-ras is less efficient in relieving the insulin requirement than is sis.
Sit
Definition:
() obs. 3d pers. sing. pres. of Sit, for sitteth.
(v. t.) To rest upon the haunches, or the lower extremity of the trunk of the body; -- said of human beings, and sometimes of other animals; as, to sit on a sofa, on a chair, or on the ground.
(v. t.) To perch; to rest with the feet drawn up, as birds do on a branch, pole, etc.
(v. t.) To remain in a state of repose; to rest; to abide; to rest in any position or condition.
(v. t.) To lie, rest, or bear; to press or weigh; -- with on; as, a weight or burden sits lightly upon him.
(v. t.) To be adjusted; to fit; as, a coat sts well or ill.
(v. t.) To suit one well or ill, as an act; to become; to befit; -- used impersonally.
(v. t.) To cover and warm eggs for hatching, as a fowl; to brood; to incubate.
(v. t.) To have position, as at the point blown from; to hold a relative position; to have direction.
(v. t.) To occupy a place or seat as a member of an official body; as, to sit in Congress.
(v. t.) To hold a session; to be in session for official business; -- said of legislative assemblies, courts, etc.; as, the court sits in January; the aldermen sit to-night.
(v. t.) To take a position for the purpose of having some artistic representation of one's self made, as a picture or a bust; as, to sit to a painter.
(v. t.) To sit upon; to keep one's seat upon; as, he sits a horse well.
(v. t.) To cause to be seated or in a sitting posture; to furnish a seat to; -- used reflexively.
(v. t.) To suit (well / ill); to become.
Example Sentences:
(1) Behind her balcony, decorated with a flourishing pothos plant and a monarch butterfly chrysalis tied to a succulent with dental floss, sits the university’s power plant.
(2) I’m not in charge of it but he’s stood up and presented that, and when Jenny, you know, criticised it, or raised some issues about grandparent carers – 3,700 of them he calculated – he said “Let’s sit down”.
(3) The adaptive filter processor was tested for retrospective identification of artifacts in 20 male volunteers who performed the following specific movements between epochs of quiet, supine breathing: raising arms and legs (slowly, quickly, once, and several times), sitting up, breathing deeply and rapidly, and rolling from a supine to a lateral decubitus position.
(4) Patients had improved sitting balance and endurance after surgery.
(5) They were protecting the sit-in because they believed that, if they left, the police would follow them."
(6) Both former presidents Bush have said they will sit out the 2016 campaign, as has former presidential candidate Jeb Bush.
(7) He missed the start of the season while rehabbing from last season's ankle injury, played exactly six games with the Los Angeles Lakers before getting hurt again and even if he's healthy he may still sit the game out .
(8) Wharton feared that if his bill had not cleared the Commons on this occasion, it would have failed as there are only three sitting Fridays in the Commons next year when the legislation could be heard again should peers in the House of Lords successfully pass amendments.
(9) One is the right not to be impeded when they are going to the House of Commons to vote, which may partly explain why the police decided to arrest Green and raid his offices last week on Thursday, when the Commons was not sitting.
(10) The inverse relation between PGE2 and NE for the difference in hormone concentrations between supine and sitting (r=-0.44, p less than 0.05) may be explained by an inhibitory effect of PGE2 on renal NE release, earlier observed in experiments in vitro.
(11) He won the Labour candidacy for the Scottish seat of Kilmarnock and Loudon in 1997, within weeks of polling day, after the sitting Labour MP, Willie McKelvey, decided to stand down when he suffered a stroke.
(12) If there’s a fire in the house, you don’t sit there saying we’re going to wait until the fire commissioner comes,” she said.
(13) I want to follow the west bank of the river south for some 100 miles to a bluff overlooking the river, where Sitting Bull is buried – and then, in the evening, to return to Bismarck.
(14) The media's image of a "gamer" might still be of a man in his teens or 20s sitting in front of Call of Duty for six-hour stretches, but that stereotype is now more inaccurate than ever.
(15) I could walk around more freely than in North Korea, but it was very apparent I was being watched.” The country consistently sits at the bottom of global freedom rankings, in the company of North Korea and Eritrea.
(16) And it means the Foreign Office dealing with those in the Middle East and North Africa who are on the side of democracy and human rights, not sitting down to tea with torturers.
(17) There can’t be something, someone that could fix this and chooses not to.” Years of agnosticism and an open attitude to religious beliefs thrust under the bus, acknowledging the shame that comes from sitting down with those the world forgot.
(18) Trump might say that is what he wants to happen but for us, that’s deeply upsetting,” says Moore, who sits on the board of the Center Against Sexual and Family Violence and expects the case to have a chilling effect on reports of abuse.
(19) Egypt has been without a sitting lower house of parliament since summer 2012, when it was dissolved by the country's supreme court .
(20) On the 18th I will be sitting down to the university Christmas meal two hours after the results are passed on to me.