(1) Chromatographic separation revealed that the bulk (85%) of the mitogenic activity in SSV-transformed NRK cells was not due to p28v-sis but rather two distinct endothelial cell growth factors that eluted off heparin-Sepharose between 1 and 2 M NaCl.
(2) To get an insight into the nature of variant Ph translocations and the process of their formation, we examined the localization of the c-abl and c-sis oncogenes and the breakpoint cluster region (bcr) gene by chromosomal in situ hybridization in ten variant Ph translocations of CML including five simple and five complex ones as initially interpreted.
(3) Loss of a c-sis allele (allele I in all cases) was observed in 6 out of 10 tumors from heterozygous patients.
(4) Cells transformed by v-sis produce a platelet-derived growth factor-related molecule which is able to stimulate the platelet-derived growth factor receptor in an autocrine fashion.
(5) The v-sis oncogene of simian sarcoma virus (SSV) is a retroviral version of the PDGF B chain gene and SSV-transformation is mediated by an autocrine PDGF-like growth factor.
(6) Messenger RNA levels for v-sis were induced by tension in intact but not denuded vessels.
(7) In both loci, similar unique genetic sequences were found upstream of the v-sis homologous region and these hybridized to a 4.2 kbp c-sis transcript in human lung tumor cells.
(8) First, we investigated the expression of c-sis protooncogenes within cultured human glioma cell lines and also fresh glioma specimens by using polymerase chain reaction.
(9) The v-sis gene encodes chain B of platelet-derived growth factor.
(10) However, in tissue adjacent to 5 different tumors, approximately the same level of c-sis mRNA was seen.
(11) c-sis mRNA levels diminished with increased time of infection.
(12) For example, platelet-derived growth factor (PDGF) has been found in many normal tissues including the CNS, while minor changes in one of its forms (PDGF-B) converts it to the v-sis oncogene, capable of inducing sarcomas and astrocytomas in primates.
(13) SIS SVB was performed to a variety of vessel combinations using "Y" graft, continuous, or vein extension techniques achieving early patency in all limbs, despite pedal arch disease.
(14) Radiolabeled recombinant PDGF (c-sis) dissociated from Heparin-Sepharose within a concentration range of NaCl similar to that of RF I.
(15) increased cell size, reduced growth rate, megakaryocytic antigens, and expression of the sis proto-oncogene, the structural gene for the B-chain of platelet-derived growth factor.
(16) In human malignant mesothelioma cell lines elevated expression of the platelet-derived growth factor (PDGF) beta-chain (c-sis) gene was previously reported, while normal mesothelial cells barely express this gene.
(17) The same temporal dissociation was observed when a recombinant v-sis product was used instead of porcine PDGF.
(18) Reduced function of runt results in female-specific lethality and sexual transformation of XX animals that are heterozygous for Sxl or sis loss-of-function mutations.
(19) Several specific related questions are addressed in this discussion: Is the protein encoded by the v-sis gene functionally identical to PDGF?
(20) This suggests that H-ras is less efficient in relieving the insulin requirement than is sis.
Six
Definition:
(a.) One more than five; twice three; as, six yards.
(n.) The number greater by a unit than five; the sum of three and three; six units or objects.
(n.) A symbol representing six units, as 6, vi., or VI.
Example Sentences:
(1) Forty-nine patients (with 83 eyes showing signs of the disease) were followed up for between six months and 12 years.
(2) In 49 cases undergoing systemic lymphadenectomy 32 were found to have glandular involvement, of which both aortic and pelvic nodes were positive in 17 cases (53.1%), aortic nodes positive but pelvic negative in six (18.8%), and pelvic nodes positive but aortic negative in nine (28.1%).
(3) Fifty-six percent of Lac+ transconjugants were resistant to the S. cremoris M12R lytic phage.
(4) These included bringing in the A* grade, reducing the number of modules from six to four, and a greater attempt to assess the whole course at the end.
(5) The rash presented either as a pityriasis rosea-like picture which appeared about three to six months after the onset of treatment in patients taking low doses, or alternatively, as lichenoid plaques which appeared three to six months after commencement of medication in patients taking high doses.
(6) Villagers, including one man who has been left disabled and the relatives of six men who were killed, are suing ABG in the UK high court, represented by British law firm Leigh Day, alleging that Tanzanian police officers shot unarmed locals.
(7) Prior to oral feeding, little or no ELA was detected in stools and endotoxinemia was ascertained in only six of 45 infants (13%).
(8) A group I subset (six animals), for which predominant cultivable microbiota was described, had a mean GI of 2.4.
(9) Biden will meet with representatives from six gun groups on Thursday, including the NRA and the Independent Firearms Owners Association, which are both publicly opposed to stricter gun-control laws.
(10) This time is approximately six months for the neuroleptics given orally, one month for antidepressants, and five and a half half-lives for benzodiazepines.
(11) Six hours later, bronchoalveolar lavage was performed.
(12) In each study, all subjects underwent four replications (over two days) of one of the six permutations of the three experimental conditions; each condition lasted 5 min.
(13) Sixty-six patients were followed for 12 months in an open safety study.
(14) Four delayed going to a medical facility and six did not have hypotension corrected.
(15) All patients were discharged home from two to six days after surgery (mean (SD) 3.7 (1.2) days).
(16) Six of the patients were operated using the McIndoe and Bannister technique while on the other two the Tobin and Day technique was used.
(17) Nine of the 12 long-term survivors showed lymph node metastasis and six of the 12 revealed cancer cells at the surgical margins.
(18) Definite tumor regression, improvement of some clinical symptoms, and continuous remission over 6 mo or more were observed in six, nine, and three patients, respectively.
(19) This method, which permits a more rapid formation of anastomoses, has been used to form Roux-en-Y jejunojejunostomies without extensive complications in six patients.
(20) Six of 7 SAO shock rats treated with U74006F survived for 120 min following reperfusion, while none of 7 SAO shock rats given the vehicle survived for 120 min (P less than .01).