(1) Chromatographic separation revealed that the bulk (85%) of the mitogenic activity in SSV-transformed NRK cells was not due to p28v-sis but rather two distinct endothelial cell growth factors that eluted off heparin-Sepharose between 1 and 2 M NaCl.
(2) To get an insight into the nature of variant Ph translocations and the process of their formation, we examined the localization of the c-abl and c-sis oncogenes and the breakpoint cluster region (bcr) gene by chromosomal in situ hybridization in ten variant Ph translocations of CML including five simple and five complex ones as initially interpreted.
(3) Loss of a c-sis allele (allele I in all cases) was observed in 6 out of 10 tumors from heterozygous patients.
(4) Cells transformed by v-sis produce a platelet-derived growth factor-related molecule which is able to stimulate the platelet-derived growth factor receptor in an autocrine fashion.
(5) The v-sis oncogene of simian sarcoma virus (SSV) is a retroviral version of the PDGF B chain gene and SSV-transformation is mediated by an autocrine PDGF-like growth factor.
(6) Messenger RNA levels for v-sis were induced by tension in intact but not denuded vessels.
(7) In both loci, similar unique genetic sequences were found upstream of the v-sis homologous region and these hybridized to a 4.2 kbp c-sis transcript in human lung tumor cells.
(8) First, we investigated the expression of c-sis protooncogenes within cultured human glioma cell lines and also fresh glioma specimens by using polymerase chain reaction.
(9) The v-sis gene encodes chain B of platelet-derived growth factor.
(10) However, in tissue adjacent to 5 different tumors, approximately the same level of c-sis mRNA was seen.
(11) c-sis mRNA levels diminished with increased time of infection.
(12) For example, platelet-derived growth factor (PDGF) has been found in many normal tissues including the CNS, while minor changes in one of its forms (PDGF-B) converts it to the v-sis oncogene, capable of inducing sarcomas and astrocytomas in primates.
(13) SIS SVB was performed to a variety of vessel combinations using "Y" graft, continuous, or vein extension techniques achieving early patency in all limbs, despite pedal arch disease.
(14) Radiolabeled recombinant PDGF (c-sis) dissociated from Heparin-Sepharose within a concentration range of NaCl similar to that of RF I.
(15) increased cell size, reduced growth rate, megakaryocytic antigens, and expression of the sis proto-oncogene, the structural gene for the B-chain of platelet-derived growth factor.
(16) In human malignant mesothelioma cell lines elevated expression of the platelet-derived growth factor (PDGF) beta-chain (c-sis) gene was previously reported, while normal mesothelial cells barely express this gene.
(17) The same temporal dissociation was observed when a recombinant v-sis product was used instead of porcine PDGF.
(18) Reduced function of runt results in female-specific lethality and sexual transformation of XX animals that are heterozygous for Sxl or sis loss-of-function mutations.
(19) Several specific related questions are addressed in this discussion: Is the protein encoded by the v-sis gene functionally identical to PDGF?
(20) This suggests that H-ras is less efficient in relieving the insulin requirement than is sis.
Vis
Definition:
(n.) Force; power.
(n.) Physical force.
(n.) Moral power.
Example Sentences:
(1) Our data do not support the possibility of hydrogen bonding between the 16 beta-hydroxyl of gitoxigenin and the lactone ring, previously suggested to account for the decreased activity of gitoxigenin vis à vis digitoxigenin, but, rather, suggest that the decreased activity may be due to an intramolecular hydrogen bond between the hydroxyls on C-14 and C-16 and an unusual D-ring conformation which combine to alter the carbonyl oxygen of the lactone ring away from the putative active position.
(2) So last week's news that, for the first time in decades, America's middle class is in relative decline vis à vis its international rivals, is more than just a statistic.
(3) The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis.
(4) In all cases the dog's level of confidence must be increased vis a vis people.
(5) The competencies expected of students upon completing their professional programs are presented in the form of 'training modules' vis-a-vis basic science, medical educational, hearing conservation, aural rehabilitation and clinical practicum.
(6) (1991) Invest Opthalmol Vis Sci 32: 1619-1629; Fain GL, Farahbakhsh (1989) J Physiol (Lond) 417: 83-103] and human lens epithelium [Cooper K et al.
(7) By using Palmore's Facts on Ageing Quiz, it was determined that client selection did in fact make a difference vis-à-vis learning outcomes about ageing and the aged.
(8) The implication of this observation is discussed vis-a-vis the determination of Ra body burden.
(9) The reaction product trans-3-indoleacryloyl-CoA (IACoA) exhibits a characteristic UV-vis absorption spectrum with lambda max = 367 nm and epsilon 367 = 26,500 M-1 cm-1.
(10) In choroid plexus thyronines effects are well pronounced and there is modulation vis a vis plasma hormone concentrations.
(11) The RI detection can be especially valuable for the determination of compounds that have low ultraviolet-visible (UV-VIS) absorptions or absorb only at low UV wavelengths.
(12) Clinical research and opinion in this area have elicited both clinical euphoria and polarization vis-a-vis newer possibilities for resolving the predicaments of partial or complete edentulism.
(13) A dual detection system utilizing uv-vis absorption and radioactive (beta-particle) detector was used to quantify total and radio-iron-bound species.
(14) A mutagenic effect was indicated either by the appearance of localized clusters of revertant colonies or by an increase in total revertant growth vis-à-vis control plates.
(15) Factors influencing ethanol elimination rate and blood acetaldehyde concentration with regard to age, blood ethanol concentration, and degrees of alcoholic liver disorder were studied in alcoholic patients vis-à-vis healthy subjects.
(16) New directions include the importance of identifying a discrepancy between what the practice is doing vis-à-vis what it should be doing as the first stage in the adoption process; the identification of the particular stage within the overall adoption process which best characterizes the practice and tailoring specific interventions to the requirements of that stage; emphasizing the reshaping of work actually performed within the practice beyond simply changing knowledge and attitudes of physicians and support personnel; recognition that there is a changing set of expectations to which the practice is at risk to be held accountable in any litigation; and finally that the interventions have realistic time expectations.
(17) And, for what it's worth, helmets and hi-vis have never been included in any Italian's definition of bella figura .
(18) To gain insight into factors associated with the excessive accumulation of beta-amyloid in the Alzheimer disease (AD) brain, the present studies were initiated to distinguish between a unique primary structure of the AD-specific amyloid precursor mRNA vis a vis other determinants that may affect amyloid levels.
(19) In contrast, all but one were restricted by angina during bycycle exercise without treatment, at a level that produced the same increase in heart rate as the handgrip test, vis.
(20) Over the 4 years of medical school, students' perception of the physician's role vis-à-vis the patient and the health care team became more specific, while their perception of the nurse's role became more vague and diffuse.