(n.) A contagious, constitutional, febrile disease characterized by a peculiar eruption; variola. The cutaneous eruption is at first a collection of papules which become vesicles (first flat, subsequently umbilicated) and then pustules, and finally thick crusts which slough after a certain time, often leaving a pit, or scar.
Example Sentences:
(1) A direct fluorescent-antibody test for smallpox is described which utilizes a conjugated antivaccinia serum that was purified by diethylaminoethyl fractionation.
(2) A notable example is percutaneous smallpox vaccination together with the intradermal injection of BCG.
(3) A young girl, vaccinated against smallpox 6 years before suffered from a persistent vaccinia virus infection and a congenital skin disease, i.e.
(4) This would prove the early reactions to be allergic responses of organisms sensitized against smallpox vaccine, capable of stimulating antibody formation.
(5) On the basis of the data obtained PHAT could be recommended as a test for the assessment of the immunological efficacy of the smallpox vaccinations.
(6) Vaccinia-specific antibodies were found in 4 human sera collected 6 weeks after smallpox vaccination.The serological results provide the first laboratory evidence of a monkeypox reservoir in wild monkeys.
(7) The last case of virulent smallpox occurred in Bangladesh in October 1975, and of mild smallpox in Ethiopia in August 1976.
(8) Since May 1980 when the 33rd World Health Assembly declared the global eradication of smallpox, WHO has been developing a comprehensive system of surveillance aimed at maintaining the world permanently free from this disease.
(9) Smallpox victims were estimated at 10-15 million each year, of whom 1.5-2.0 million died.
(10) Five instances of side-effects after oral smallpox immunisation (out of 2568 persons orally immunised) are reported.
(11) In 1796, Edward Jenner developed the first effective vaccine against an infectious disease by using cowpox virus to prevent subsequent infection with smallpox.
(12) Subcutaneous sensitization of guinea pigs with -vaccine, and also an intracardiac injection of smallpox or measles vaccine induced production of brain autoantibodies, whereas subcutaneous or intradermal immunization of the animals with liver viral vaccines was not accompanied by the formation of autoantibodies and development of the pathological processes in the nervous system tissue.
(13) If this is verified, we may say farewell to routine smallpox vaccination.
(14) Useful lessons may be drawn from the successful global Smallpox Eradication Program and applied to the current campaign in the areas of surveillance, strategy, operations, and evaluation.
(15) With this immunization schedule it was possible to obtain smallpox antisera containing precipitins (in a titer of 1:32), hemagglutinins (1:1280), and antibody detectable by the indirect immunofluorescence technique (1:2560).
(16) In sequential serum specimens, the radioimmunoassay test indicated fourfold or greater increases in all of the smallpox patients and in six of eight vaccinated persons.
(17) The obstetric outcome (abortions, stillbirths, prematurity, mature births, and congenital abnormalities) in a group of 1522 consecutive pregnant patients who had smallpox vaccinations during recent pregnancies was compared to that in a similar control group of 2024 consecutive pregnant patients who did not receive any antenatal vaccination.
(18) In this pilot study clinical, electrocardiographic, chemical and immunological findings have been studied during a six weeks' follow-up after routine immunisation (mumps, polio, tetanus, smallpox, diphtheria and type A meningococcal disease) among 234 Finnish conscripts at the beginning of their military service.
(19) The history of smallpox is recounted through the eyes of those who bore witness to its terrors.
(20) All were tuberculin-tested and all had received primary smallpox vaccination but had not been vaccinated with BCG.
Virus
Definition:
(v. i.) Contagious or poisonous matter, as of specific ulcers, the bite of snakes, etc.; -- applied to organic poisons.
(v. i.) The special contagion, inappreciable to the senses and acting in exceedingly minute quantities, by which a disease is introduced into the organism and maintained there.
(v. i.) Fig.: Any morbid corrupting quality in intellectual or moral conditions; something that poisons the mind or the soul; as, the virus of obscene books.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) These results show that the pathogenic phenotypes of MCF viruses are dissociable from the thymotropic phenotype and depend, at least in part, upon the enhancer sequences.
(3) It is quite interesting to analyse which gene of the virus determines the characteristics of the virus.
(4) The extent of the infectious process was limited, however, because the life span of the cultures was not significantly shortened, the yields of infectious virus per immunofluorescent cell were at all times low, and most infected cells contained only a few well-delineated small masses of antigen, suggestive of an abortive infection.
(5) The promoters of the adenovirus 2 major late gene, the mouse beta-globin gene, the mouse immunoglobulin VH gene and the LTR of the human T-lymphotropic retrovirus type I were tested for their transcription activities in cell-free extracts of four cell lines; HeLa, CESS (Epstein-Barr virus-transformed human B cell line), MT-1 (HTLV-I-infected human T cell line without viral protein synthesis), and MT-2 (HTLV-I-infected human T cell line producing viral proteins).
(6) It was also able to inhibit the binding both of alpha-bungarotoxin and rabies virus glycoprotein to the acetylcholine receptor.
(7) Subtypes of HBs Ag are already of great use in the epidemiology of hepatitis B virus infections; yet they may have additional significance.
(8) PMN were found to be nonpermissive for HSV replication and were unable to bind virus in the absence of antibody.
(9) Analysis revealed some significant differences in the false-positive rate, depending on the test method used or virus samples evaluated.
(10) The transported pIgA was functional, as evidenced by its ability to bind to virus in an ELISA assay and to protect nonimmune mice against intranasal infection with H1N1 but not H3N2 influenza virus.
(11) The p60v-src protein encoded by Prague Rous sarcoma virus was found to contain two sites of tyrosine phosphorylation.
(12) Other research has indicated that placing gossypol in the vagina does inhibit the effect of herpes simplex virus type 2 infection, however.
(13) The causative organisms included viruses, fungi, and bacteria of both high and low pathogenicity.
(14) The antiproliferative activity of IFN was studied using the parental L cell line, a tk- derivative, and a tk- (tk+) subline into which the tk gene of herpes simplex virus was introduced.
(15) It could be demonstrated by radioimmune precipitation of virus labeled with[35S]methionine that all three polypeptides are specific for hog cholera virions.
(16) Hyperimmunization with the tick encephalitis and Western horse encephalomyelitis viruses reproduced in the brain of albino mice, intensified the protein synthesis in the splenic tissue during the productive phase of the immunogenesis (the 7th day).
(17) No cross reactions were found between bluetongue and epizootic haemorrhagic disease of deer viruses.
(18) Cytolytic T lymphocytes lysing virus-infected and uninfected myocytes and heart-reactive autoantibodies occur in both myocarditis-susceptible strains.
(19) Whole-virus vaccines prepared by Merck Sharp and Dohme (West Point, Pa.) and Merrell-National Laboratories (Cincinnati, Ohio) and subunit vaccines prepared by Parke, Davis and Company (Detroit, Mich.) and Wyeth Laboratories (Philadelphia, Pa.) were given intramuscularly in concentrations of 800, 400, or 200 chick cell-agglutinating units per dose.
(20) We have recently described a nonnucleoside compound that specifically inhibits the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS.