(a.) Filled with, or showing, spite; having a desire to vex, annoy, or injure; malignant; malicious; as, a spiteful person or act.
Example Sentences:
(1) In spite of dense lymphocytic infiltration only 3% of the tumor infiltrating lymphocytes exhibit the activation marker CD 25.
(2) When labelled long-chain fatty acids or glycerol were infused into the lactating goat, there was extensive transfer of radioactivity into milk in spite of the absence of net uptake of substrate by the mammary gland.
(3) In spite of important differences in size, chemical composition, polymer density, and configuration, biological macromolecules indeed manifest some of the essential physical-chemical properties of gels.
(4) Mastitis in its complexity has managed to forestall all efforts of eradication in spite of years of research, antibiotics and practical control measures.
(5) In spite of antimalaria treatment, with cortisone and then with immuno-depressants, the outcome was fatal with a picture of acute reticulosis and neurological disorders.
(6) In spite of the presence of scar tissue following rhytidectomy, this procedure has been quite successful because of the rich blood supply in that area.
(7) By the GN of non-streptococcal etiology, AA's to the BLSE apparently of other specificity are obtained in some cases, in spite of the absence of antibodies to A-PS.
(8) In spite of the formation of the epoxide intermediate, no binding of [14C]d-limonene equivalents to mouse kidney proteins was observed.
(9) No cases of rheumatic fever and no acute nephritis appeared in spite of the vigorous immune response to both cellular and extracellular antigens of group A streptococci documented in 50% to 80% of patients, suggesting that strain variation may be a feature of rheumatogenicity as well as nephritogenicity of group A streptococcal pharyngitis.
(10) Clinical and inflammatory activity improved in both groups, but consistently more so in the auranofin group, in spite of the greater consumption of local steroids and NSAIDs in the placebo group.
(11) The reported case of fetal infection in spite of previous rubella vaccination of the mother does not discourage the use of rubella vaccine.
(12) Although operative mortality was significantly greater for women during most of this review period, mortality was similar during 1983 (2.6% for men versus 2.4% for women), in spite of a significantly higher incidence of unstable angina in the female group (54% for women versus 35% for men).
(13) The shapes of the curves for soleus and tibialis anterior are similar in spite of the different mechanical conditions of the two muscles.
(14) In spite of the limitations arising from the complex geometry of the right ventricule, echocardiography may be the most important non-invasive technique in the evaluation of the structural and functional repercussion of hypertension on the right ventricle.
(15) Thus, in spite of its excellent activity and unquestionable effectiveness, rifampicin should be used with caution in severe staphylococcal infections.
(16) My son was born healthy, strong and very handsome, in spite of his dangerous start.
(17) The great clinical value of the procedure is shown by the following findings:X-ray-negative lesions--including 2 cases of carcinoma--were found in 35 percent of the cases, radiologically demonstrated lesions could be defined more precisely in 18 percent, and the presence of colonic lesions could be ruled out in 11 percent in spite of equivocal X-ray findings.
(18) In spite of low fluoride content in their water supply, the findings revealed a generally low prevalence of caries experience (DMFT 1.26).
(19) In anesthetized cats, the enhancement of sympathetic activity and increase of the blood pressure in exclusion of afferents (section of vagosympathetic trunks and clamping of common carotid arteries) as well as the disappearance of the activity in enhanced afferentation, were shown to be transient and to disappear within a few minutes-scores of minutes in spite of the going on deafferentation or enhancement of afferentation.
(20) By modifying the spatial distribution of afferents to the network, we demonstrate that the same basic model functions properly in spite of afferents with nonuniform background firing rates.
Spleenful
Definition:
(a.) Displaying, or affected with, spleen; angry; fretful; melancholy.
Example Sentences:
(1) At the early phase of the sensitization a T-cell response was seen in vitro, characterized by an increased spleen but no peripheral blood lymphocyte reactivity to T-cell mitogens at the same time as increased reactivity to the sensitizing antigen was detected.
(2) Most of the radioactivity in spleen cells from these rats were associated with antigen-reactive cells which formed rosettes specifically with HO erythrocytes.
(3) Reactive metabolites which suppress splenic humoral immune responses are thought to be generated within the spleen rather than in distant tissues.
(4) Pokeweed mitogen-stimulated rat spleen cells were identified as a reliable source of rat burst-promoting activity (PBA), which permitted development of a reproducible assay for rat bone marrow erythroid burst-forming units (BFU-E).
(5) Release of 51Cr was apparently a function of immune thymus-derived lymphocytes (T cells) because it was abrogated by prior incubation of spleen cells with anti-thymus antiserum and complement but was undiminished by passage of spleen cells through nylon-wool columns.
(6) Moreover, the data showed for the first time that DNA synthesis in the bone marrow and spleen and colon were markedly statistically significantly stimulated at specific times after treatment.
(7) High radioactivities were observed in the digestive organs, mesenteric lymphnodes, liver, pancreas, urinary bladder, fat tissue, kidney and spleen after oral administration to rats.
(8) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(9) Proliferation of quiescent hematopoietic stem cells, purified by cell sorting and evaluated by spleen colony assay (CFU-S), was investigated by measuring the total cell number and CFU-S content and the DNA histogram at 20 and 48 hours of liquid culture.
(10) In investigation of AMLR composed of peripheral blood cells and spleen cells of gastric cancer patient, AMLR on splenic non-T cells as a stimulator was significantly suppressed compared with peripheral blood non-T cells as a stimulator.
(11) During the development of Shvets' leukosis, the weight of spleen and lymph glands and their lymphocyte content change enormously while the number of plasmocytes rises exponentially.
(12) A constellation of histologic lesions was identified in brain (diffuse meningoencephalitis with bilaterally symmetrical thalamic necrosis), liver (pericholangiohepatitis), lung (pneumonitis), and spleen (lymphoid hyperplasia); this tetrad is apparently unique to this model system.
(13) The bursa of Fabricius, thymus glands and spleen of chickens were also shown to express mRNA coding for ANP.
(14) For routine use, 50 mul of 12% BTV SRBC, 0.1 ml of a spleen cell suspension, and 0.5 ml of 0.5% agarose in a balanced salt solution were mixed and plated on a microscope slide precoated with 0.1% aqueous agarose.
(15) Polyadenylic-polyuridylic acid complexes (poly A:U) at the 1-5 mu g level, were mitogenic for spleen cells when given intravenously to normal Balb or cortisone-treated mice.
(16) Mixing experiments were performed to test the putative inhibitory effects of allotype-suppressed spleen cells from the first adoptive transfer (stage I) on the antibody response of normal spleen cells in a second adoptive transfer (stage II).
(17) After birth, it was in the liver and spleen up to 6 weeks af age, and thereafter it was present only in the bone marrow.
(18) Only the group that received 3R spleen cells treated with anti I-Jb monoclonal antibody and C' had no suppressed PFC.
(19) Prior incubation of these antigens with test spleen cells in the agar gel effictively inhibited development of the vibriolytic plaques, regardless of antibody class.
(20) Four hours after injection radioactivity was identified in the spleen, liver, and bone marrow.