(a.) Filled with, or showing, spite; having a desire to vex, annoy, or injure; malignant; malicious; as, a spiteful person or act.
Example Sentences:
(1) In spite of dense lymphocytic infiltration only 3% of the tumor infiltrating lymphocytes exhibit the activation marker CD 25.
(2) When labelled long-chain fatty acids or glycerol were infused into the lactating goat, there was extensive transfer of radioactivity into milk in spite of the absence of net uptake of substrate by the mammary gland.
(3) In spite of important differences in size, chemical composition, polymer density, and configuration, biological macromolecules indeed manifest some of the essential physical-chemical properties of gels.
(4) Mastitis in its complexity has managed to forestall all efforts of eradication in spite of years of research, antibiotics and practical control measures.
(5) In spite of antimalaria treatment, with cortisone and then with immuno-depressants, the outcome was fatal with a picture of acute reticulosis and neurological disorders.
(6) In spite of the presence of scar tissue following rhytidectomy, this procedure has been quite successful because of the rich blood supply in that area.
(7) By the GN of non-streptococcal etiology, AA's to the BLSE apparently of other specificity are obtained in some cases, in spite of the absence of antibodies to A-PS.
(8) In spite of the formation of the epoxide intermediate, no binding of [14C]d-limonene equivalents to mouse kidney proteins was observed.
(9) No cases of rheumatic fever and no acute nephritis appeared in spite of the vigorous immune response to both cellular and extracellular antigens of group A streptococci documented in 50% to 80% of patients, suggesting that strain variation may be a feature of rheumatogenicity as well as nephritogenicity of group A streptococcal pharyngitis.
(10) Clinical and inflammatory activity improved in both groups, but consistently more so in the auranofin group, in spite of the greater consumption of local steroids and NSAIDs in the placebo group.
(11) The reported case of fetal infection in spite of previous rubella vaccination of the mother does not discourage the use of rubella vaccine.
(12) Although operative mortality was significantly greater for women during most of this review period, mortality was similar during 1983 (2.6% for men versus 2.4% for women), in spite of a significantly higher incidence of unstable angina in the female group (54% for women versus 35% for men).
(13) The shapes of the curves for soleus and tibialis anterior are similar in spite of the different mechanical conditions of the two muscles.
(14) In spite of the limitations arising from the complex geometry of the right ventricule, echocardiography may be the most important non-invasive technique in the evaluation of the structural and functional repercussion of hypertension on the right ventricle.
(15) Thus, in spite of its excellent activity and unquestionable effectiveness, rifampicin should be used with caution in severe staphylococcal infections.
(16) My son was born healthy, strong and very handsome, in spite of his dangerous start.
(17) The great clinical value of the procedure is shown by the following findings:X-ray-negative lesions--including 2 cases of carcinoma--were found in 35 percent of the cases, radiologically demonstrated lesions could be defined more precisely in 18 percent, and the presence of colonic lesions could be ruled out in 11 percent in spite of equivocal X-ray findings.
(18) In spite of low fluoride content in their water supply, the findings revealed a generally low prevalence of caries experience (DMFT 1.26).
(19) In anesthetized cats, the enhancement of sympathetic activity and increase of the blood pressure in exclusion of afferents (section of vagosympathetic trunks and clamping of common carotid arteries) as well as the disappearance of the activity in enhanced afferentation, were shown to be transient and to disappear within a few minutes-scores of minutes in spite of the going on deafferentation or enhancement of afferentation.
(20) By modifying the spatial distribution of afferents to the network, we demonstrate that the same basic model functions properly in spite of afferents with nonuniform background firing rates.
Wicked
Definition:
(a.) Having a wick; -- used chiefly in composition; as, a two-wicked lamp.
(a.) Evil in principle or practice; deviating from morality; contrary to the moral or divine law; addicted to vice or sin; sinful; immoral; profligate; -- said of persons and things; as, a wicked king; a wicked woman; a wicked deed; wicked designs.
(a.) Ludicrously or sportively mischievous; disposed to mischief; roguish.
Example Sentences:
(1) "I had a not altogether satisfactory talk with Mark this morning" begins a typical confidential memo from Nigel Wicks, Mrs Thatcher's principal private secretary, to the British ambassador in Washington.
(2) It’s a wicked thing to do.” Thomson said the federal government had not notified him about approaching boats since 2009.
(3) It blamed "confrontation maniacs" for "[making their] servants of conservative media let loose a whole string of sophism intended to hatch all sorts of dastardly wicked plots and float misinformation".
(4) Fluid pressure changes and digital load measurements were simultaneously detected and recorded by use of, respectively, modified wick-in-needle and force plate transducers coupled to a microcomputer.
(5) In cats, brain tissue pressure (BTP) was measured by the wick-catheter method.
(6) The lack of knowledge about proper feeding and the use of bottles, fingers, and cotton wicks, which contribute to infection, diarrhea, and malnutrition, indicates a need for better health education.
(7) The light stimuli are provided by a Ganzfeld stimulator and the potentials are recorded with a disposable corneal wick electrode.
(8) IFP was measured in squamous cell carcinomas of the head and neck region in humans using the wick-in-needle technique.
(9) Our results on Ap4A are in contrast with those reported previously (C. Weinmann-Dorsch, G. Pierron, R. Wick, H. Sauer, and F. Grummt, Exp.
(10) Resembling a billhook, with Foule Crag its wickedly curved tip, this final flourish looks daunting but can be skirted to one side, up awkward slabs.
(11) titration with wicks pre-loaded with serial dilutions of rat plasma implanted post mortem for 15-20 min.
(12) Dance, perform, party in Hackney Wick One of my favourite venues in London is The Yard Theatre.
(13) Less conventional still is Muff Cafe, a custom-motorbike-workshop-cum-really-rather-good-organic-restaurant in Hackney Wick that a friend recommends on condition that "you don't fill it with Guardian readers".
(14) The wick catheter technique was developed in 1968 for measurement of subcutaneous pressure and has been modified for easy intramuscular insertion and continuous recording of interstitial fluid pressure in animals and humans.
(15) The corneal wick electrode is employed for bright flash electroretinogram (ERG) recordings and for research measurements of the early receptor potential.
(16) In the longer term, there is a risk that local government will be seen as being wicked or incompetent as it struggles to meet George Osborne's new spending figures.
(17) His next book was The Great Crash 1929 (1955), a wickedly entertaining account of what happened on Wall Street in that year.
(18) The mistake in most international crises is to over-personalise the issue by making a pariah of the wicked man and his corrupt family at the top and thinking that, once they go, all problems will easily be solved.
(19) Come the bell, the upstart nervelessly played it cool, almost a laughingly gay matador, his speed of hand and foot totally nullifying Liston’s wicked jab, the key to his armoury.
(20) Tissue pressures were recorded using saline-filled cotton-wool wicks.