(a.) Belonging to substance; actually existing; real; as, substantial life.
(a.) Not seeming or imaginary; not illusive; real; solid; true; veritable.
(a.) Corporeal; material; firm.
(a.) Having good substance; strong; stout; solid; firm; as, substantial cloth; a substantial fence or wall.
(a.) Possessed of goods or an estate; moderately wealthy; responsible; as, a substantial freeholder.
Example Sentences:
(1) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(2) 10D1 mAb induced a substantial proliferation of peripheral blood T cells when cross-linked with goat anti-mouse Ig antibody.
(3) Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency.
(4) Previous studies in this laboratory with particulate Mn3O4 have shown that preweanling rats have substantially higher tissue Mn concentrations than similarly treated adults, indicating possible differences in uptake or elimination or both.
(5) A more substantial decrease was found in Aberdeen and the larger towns near to Aberdeen than in the smaller towns further from the city.
(6) In contrast, human breast milk contained substantially increased levels of immunoreactive PTHrP.
(7) It was found that there was a substantial increase in mortality rates in the area under the jets where there was large noise radiation.
(8) But the amount of time spent above SPA has differed substantially between men and women due to women both living longer, and reaching state pension age earlier.
(9) Although statistical analysis did not show dramatic changes in all these parameters, some individual extreme values were substantially altered.
(10) Cholestyramine resin was beneficial in reducing stool bulk but had no substantial effect on fat absorption.
(11) Accordingly, LPA proved an extremely stable characteristic which did not show any substantial variations in the course of five years.
(12) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(13) Mitogen-stimulated cells always contain substantially higher levels of LDL receptor messenger RNA than corresponding resting cells.
(14) Considerable glucose 6-phosphatase activity survived 240min of treatment with phospholipase C at 5 degrees C, but in the absence of substrate or at physiological glucose 6-phosphate concentrations the delipidated enzyme was completely inactivated within 10min at 37 degrees C. However, 80mM-glucose 6-phosphate stabilized it and phospholipid dispersions substantially restored thermal stability.
(15) Amine metabolites, 5-hydroxyindoleacetic acid (5HIAA), and homovanillic acid (HVA) were not substantially affected by sleep deprivation, although there was a significant interaction of clinical response and direction of 3-methoxy-4-hydroxyphenylglycol (MHPG) change.
(16) The department of dietetics at a large teaching hospital has substantially reduced its food and labor costs through use of computerized systems that ensure efficient inventory management, recipe standardization, ingredient control, quantity and quality control, and identification of productive man-hours and appropriate staffing levels.
(17) Substantial percentages of both physicians and medical students reported access to drugs, family histories of substance abuse, stress at work and home, emotional problems, and sensation seeking.
(18) For further education, this would be my priority: a substantial increase in funding and an end to tinkering with the form of qualifications and bland repetition of the “parity of esteem” trope.
(19) The family members of depressed patients with six or more groups of DSM-III symptoms of major depression exhibited substantially higher rates of mood disorders than the family members of depressed patients with fewer than six groups of symptoms and the family members of patients with nonaffective disorders.
(20) The results presented here substantiate the hypothesis that in S. cerevisiae trehalose supplies energy during dormancy of the spores and not during the germination process.
Weighty
Definition:
(superl.) Having weight; heavy; ponderous; as, a weighty body.
(superl.) Adapted to turn the balance in the mind, or to convince; important; forcible; serious; momentous.
(superl.) Rigorous; severe; afflictive.
Example Sentences:
(1) It is appropriate that AIDS be responded to as a crisis, but we also have a weighty, preexisting set of long-standing and equally lethal health and social ills.
(2) Weighty stuff, but critics hailed the show as the neurotic standup’s best in years.
(3) They imply that it is a matter of weighty regret that things have now reached a pass where their only conscionable option is to declare "thus far and no further".
(4) 4S, 5S, AND 18S + 28S RNA from the newt Taricha granulosa granulosa were iodinated in vitro with carrier-free 125I and hybridized to the denatured chromosomes of Taricha granulosa and Batrachoseps weighti.
(5) We'll be here until then and beyond, sharing every rumour nugget, insightful news line and weighty analysis we can muster.
(6) Little ones might freak out a bit at the wax characters and the gloomy dark but this is a fun way to bring a fairly weighty school text to life.
(7) In contrast, D changed from left weightiness to symmetry, coinciding with improvement but not with deterioration, With reference to the latter findings we discuss the possibility of a particular mode of cerebral lateralization predisposing to endogenous depression.
(8) The DPA is a weighty US drug policy reform NGO that can boast tycoons such as George Soros and Richard Branson and celebrities including Sting on its board of directors.
(9) Then there were the imported dramas broadcast because they were weighty, such as 1984's Heimat , an enthralling dramatisation of ordinary lives in 20th-century Germany.
(10) At the time of his resignation he had far more weighty matters filling his in-tray than the NRB case, not least a probe into alleged corruption among some of Boris Yeltsin's close relatives.
(11) Brennan bridles at that, saying it would be "a very weighty decision in terms of declassifying that report."
(12) In the Nederlandsch Tijdschrift voor Geneeskunde the last-mentioned aspect appears to have been very weighty, especially in the beginning.
(13) Weighty, expensive impact reports sit hidden deep within websites (or worse, annual reports), while the public remains oblivious to what happens to donations.
(14) They're running almost entirely on biscuits and cans of Red Bull, kept awake by a mix of jokes, weighty debate, and general good humour.
(15) It's an extra nerdy and intelligent version too, with tactical jedi Jonathan Wilson and his young apprentic Zonal Marking's Michael Cox there to provide the yuks and giggles as myself and James Richardson analyse the weighty football issues of the day to within an inch of their lives.
(16) The world will long remember their son Edward as the heir to a weighty legacy; a champion for those who had none; the soul of the Democratic party; and the lion of the US Senate – a man whose name graces nearly one thousand laws, and who penned more than 300 himself.
(17) It was the world of John Smith, razor-sharp debating, forensic examination of weighty issues and Gaitskellite intrigues.
(18) A comparison between the activity of the two hands yielded a pronounced left-weightiness of object-focused, continuous body-focused and discrete body-focused movements in contrast to findings on normal persons.
(19) The chancellor demanded that officials develop weighty evidence about whether or not the new 50p rate was working.
(20) The science report is the first of three major IPCC reports this year; similarly weighty analysis of the impact and possible solutions will follow in April and May respectively.