(n.) One who, or that which, is substituted or put in the place of another; one who acts for another; that which stands in lieu of something else
(n.) a person who enlists for military service in the place of a conscript or drafted man.
(n.) To put in the place of another person or thing; to exchange.
Example Sentences:
(1) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(2) In the clinical trials in which there was complete substitution of fat-modified ruminant foods for conventional ruminant products the fall in serum cholesterol was approximately 10%.
(3) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(4) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(5) The resonance Raman spectra of oxy and deoxy cobalt-substituted hemoglobin (CoHb) are reported.
(6) The most important conclusion of both conferences was that oestrogen substitution can significantly reduce the incidence of fractures in postmenopausal women.
(7) S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine.
(8) This implies that the epitope(s) of NNA-PLA2 might comprise some substituted residues in the sequence of PLA2 homologues.
(9) The deletions and substitutions appear to occur in separate molecules.
(10) Combination of domain substitutions to generate the [Glu107,123]bFGF and [Arg19,Lys123,126]bFGF mutants did not show any additivity of the mutations on biological activity.
(11) N-Methoxysulphonamides showed no inhibitory activity, as predicted by the classic work of Krebs on N-substituted inhibitors.
(12) Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N-methyl-D-glucamine HCl.
(13) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(14) Substitutes: Andoni Zubizarreta (Spain), Lajos Detari (Hungary), Dragan Stojkovic (Yugoslavia), Igor Belanov (USSR), Preben Elkjær Larsen (Denmark), Lars Larsson (Sweden), Alexandre Zavarov (USSR).
(15) Lipoprotein concentrations reverted to normal after substitution with thyroxine (T4) until the euthyroid state was reached.
(16) Taken together with our previous studies showing that MDMA substitutes for the phenylisopropylamine stimulant (+)amphetamine, but that neither MDE nor N-OH MDA substitute for (+)amphetamine or for the phenylisopropylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), the present results [i.e., MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine] suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N-OH MDA are MDMA-like agents with even less of an amphetamine-like component of action than MDMA itself.
(17) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
(18) Substitution of DnaK protein with that of the mutant DnaK756 protein blocks lambda P release.
(19) To selectively stain polyanionic macromolecules of growth plate cartilage and to prevent artifacts induced by aqueous fixation, proximal tibial growth plates were excised from rats, slam-frozen, and freeze-substituted in 100% methanol containing the cationic dye Alcian blue.
(20) Plasma drug concentrations, subjective self-ratings, and the digit symbol substitution test (DSST) were evaluated during 24 hours after dosage.
Vaccine
Definition:
(a.) Of or pertaining to cows; pertaining to, derived from, or caused by, vaccinia; as, vaccine virus; the vaccine disease.
(n.) The virus of vaccinia used in vaccination.
(n.) any preparation used to render an organism immune to some disease, by inducing or increasing the natural immunity mechanisms. Prior to 1995, such preparations usually contained killed organisms of the type for which immunity was desired, and sometimes used live organisms having attenuated virulence. since that date, preparations containing only specific antigenic portions of the pathogenic organism are also used, some of which are prepared by genetic engineering techniques.
Example Sentences:
(1) We were able to detect genetic recombination between vaccine strains of PRV following in vitro or in vivo coinoculation of 2 strains of PRV.
(2) Attempts are now being made to use this increased understanding to produce effective killed vaccines that produce immune responses in the lung.
(3) We have measured the antibody specificities to the two polysaccharides in sera from asymptomatic group C meningococcal carriers and vaccinated adults by a new enzyme-linked immunosorbent assay (ELISA) procedure using methylated human serum albumin for coating the group C polysaccharide onto microtiter plates.
(4) The simultaneous administration of the yellow fever vaccine did not influence the titre of agglutinins induced by the classic cholera vaccine.
(5) Before carrier vaccines are applied, these risks must be thoroughly evaluated case-by-case.
(6) Whole-virus vaccines prepared by Merck Sharp and Dohme (West Point, Pa.) and Merrell-National Laboratories (Cincinnati, Ohio) and subunit vaccines prepared by Parke, Davis and Company (Detroit, Mich.) and Wyeth Laboratories (Philadelphia, Pa.) were given intramuscularly in concentrations of 800, 400, or 200 chick cell-agglutinating units per dose.
(7) The prophylactic effect of immunization with P. aeruginosa polyvalent corpuscular vaccine has been shown on the model of P. aeruginosa generalized chronic infection in mice with leukopenia induced by the intraperitoneal injection of cyclophosphamids.
(8) The data support inclusion of these residues in future CS protein vaccines.
(9) By vaccinating adult dogs in boarding kennels the morbidity rate dropped from 83.5% to 6.5% and the mortality rate from 4.1% to 0.5%.
(10) It is clear that before general release of a new living feline infectious enteritis vaccine, there must be satisfactory evidence that concurrent infection will not affect the safety of the modified antigen.In cats infected with feline infectious enteritis there appears to be a short period, coinciding with the onset of leucopaenia, during which they are highly infectious.
(11) The combination vaccine consisted of 12 Lf tetanus toxoid and 10 TCID50 vaccinia virus "MVA" preserved with gelatine and glucosamine.
(12) We evaluated the safety and efficacy of a conjugate vaccine that links the H. influenzae type b capsular polysaccharide to the outer-membrane protein complex (OMPC) of Neisseria meningitidis serogroup B.
(13) The litter size of vaccinated gilts was larger than that of the control gilts.
(14) The SNT and the I-ELISA indicated that the pigs responded to vaccination and challenge.
(15) The value of benefit-risk, benefit-cost, and cost-effectiveness analyses lies not in providing the definitive basis for a decision on vaccine use or evaluation.
(16) Injection of about four ImD 50 of vaccine intracerebrally produced a local immunity, resulting in an immediate kill of challenge organisms given 14 days later.
(17) For the purpose of studying the role of elastase and protease of Pseudomonas aeruginosa in bacterial infection in burns, the effects of the vaccines made from each enzyme, their toxoids and OEP on protection against infection in burned mice were studied.
(18) No vaccination reactions were noted, although most birds involved in the trials were carrying Mycoplasma spp.
(19) Serum from piglets of vaccinated sows had no more bactericidal activity than did sera from non-vaccinated sows.
(20) The purpose of this study was to investigate a tumor cell vaccine delivered via peripheral lymphatics as maintenance therapy after induction of remission with chemotherapy.