(n.) The act of substituting or putting one person or thing in the place of another; as, the substitution of an agent, attorney, or representative to act for one in his absense; the substitution of bank notes for gold and silver as a circulating medium.
(n.) The state of being substituted for another.
(n.) The office or authority of one acting for another; delegated authority.
(n.) The designation of a person in a will to take a devise or legacy, either on failure of a former devisee or legatee by incapacity or unwillingness to accept, or after him.
(n.) The doctrine that Christ suffered vicariously, being substituted for the sinner, and that his sufferings were expiatory.
(n.) The act or process of substituting an atom or radical for another atom or radical; metethesis; also, the state of being so substituted. See Metathesis.
Example Sentences:
(1) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(2) In the clinical trials in which there was complete substitution of fat-modified ruminant foods for conventional ruminant products the fall in serum cholesterol was approximately 10%.
(3) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(4) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(5) The resonance Raman spectra of oxy and deoxy cobalt-substituted hemoglobin (CoHb) are reported.
(6) The most important conclusion of both conferences was that oestrogen substitution can significantly reduce the incidence of fractures in postmenopausal women.
(7) S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine.
(8) This implies that the epitope(s) of NNA-PLA2 might comprise some substituted residues in the sequence of PLA2 homologues.
(9) The deletions and substitutions appear to occur in separate molecules.
(10) Combination of domain substitutions to generate the [Glu107,123]bFGF and [Arg19,Lys123,126]bFGF mutants did not show any additivity of the mutations on biological activity.
(11) N-Methoxysulphonamides showed no inhibitory activity, as predicted by the classic work of Krebs on N-substituted inhibitors.
(12) Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N-methyl-D-glucamine HCl.
(13) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(14) Substitutes: Andoni Zubizarreta (Spain), Lajos Detari (Hungary), Dragan Stojkovic (Yugoslavia), Igor Belanov (USSR), Preben Elkjær Larsen (Denmark), Lars Larsson (Sweden), Alexandre Zavarov (USSR).
(15) Lipoprotein concentrations reverted to normal after substitution with thyroxine (T4) until the euthyroid state was reached.
(16) Taken together with our previous studies showing that MDMA substitutes for the phenylisopropylamine stimulant (+)amphetamine, but that neither MDE nor N-OH MDA substitute for (+)amphetamine or for the phenylisopropylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), the present results [i.e., MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine] suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N-OH MDA are MDMA-like agents with even less of an amphetamine-like component of action than MDMA itself.
(17) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
(18) Substitution of DnaK protein with that of the mutant DnaK756 protein blocks lambda P release.
(19) To selectively stain polyanionic macromolecules of growth plate cartilage and to prevent artifacts induced by aqueous fixation, proximal tibial growth plates were excised from rats, slam-frozen, and freeze-substituted in 100% methanol containing the cationic dye Alcian blue.
(20) Plasma drug concentrations, subjective self-ratings, and the digit symbol substitution test (DSST) were evaluated during 24 hours after dosage.
Successor
Definition:
(n.) One who succeeds or follows; one who takes the place which another has left, and sustains the like part or character; -- correlative to predecessor; as, the successor of a deceased king.
Example Sentences:
(1) Environmental campaigners had been apprehensive about the chances of the Senate ratifying a new international treaty – a successor to the Kyoto protocol – to combat global warming unless a consensus had already been reached on Capitol Hill.
(2) As luck would have it, the outgoing Bartlet and his successor, Matt Santos, are currently dealing with a foreign crisis, too.
(3) With Everton heading for a sixth-placed finish in the Premier League, the additional television revenue and prospect of further funds from Fellaini, the club are confident of appointing an "equally significant" successor to Moyes, according to the chairman, Bill Kenwright.
(4) The chances of Sam Allardyce becoming the next England manager have been enhanced by his willingness to help the Football Association to mentor a young assistant who would be groomed as his successor.
(5) Academisation and a school system on the brink | Letters Read more Perry Beeches has been a favourite of Cameron, as well as former education secretary Michael Gove and his successor Nicky Morgan .
(6) The current president of the supreme court, Lord Phillips, who steps down at the end of September, welcomed his successor, praising his "wealth of judicial experience" and "ability to lead a collegiate court".
(7) Others believe that, despite the fact that some of his closest lieutenants are among those indicted by US authorities, he planned to use the time until the new election to ease a favoured successor into the post.
(8) With the White House backing away and fellow Republicans openly considering successors, Mr Lott's hard-fought campaign to sit out the controversy appeared doomed.
(9) Arapahovius seems to have had no phylogenetic successors.
(10) He considers himself more of a tracksuit coach, despite seeing his influence with the younger age groups at St George’s Park diminished since Matt Crocker swapped Southampton for the FA to become head of player and coach development, but would be more than happy to be part of the body’s consultation process as they seek to identify Hodgson’s successor.
(11) 'Have a thick skin' – sex discrimination commissioner's advice to her successor Read more Labor said it was “a disgrace for women everywhere” that the government was delaying appointing a replacement for Elizabeth Broderick, the long-serving commissioner whose term expired four months ago.
(12) But the damage from the whole affair and inevitable scrutiny of her successor might just mean they take a more even-handed approach to the job.
(13) The constitution states that he will remain president until his successor is elected,” Kikaya said.
(14) The two reformists Mr Mousavi and Mehdi Karroubi have sought to portray themselves as the true heirs of the Islamic revolution's spiritual leader, the late Ayatollah Khomeini, but this tactic has since worn thin and Khomeini's successor Ayatollah Ali Khamenei has stepped up his drive to paint Mousavi and Karroubi as western-run heretics.
(15) Spain goes to the polls at the weekend to find a successor to the administration of José Luis Rodríguez Zapatero.
(16) Also note chatter of Bernanke stepping down next week (6-weeks early), if successor Yellen gained full Senate approval, allowing her to chair the December FOMC meeting.
(17) The process to select his successor will be independent of government, but we will be keeping a close eye on the situation.
(18) It was in that period that Ronald Reagan lent official US recognition to the Palestine Liberation Organisation, making a move that would have been too costly for his successor, Bush the elder.
(19) Political conflict stemming from parliamentary disputes should be resolved within the legislative council.” Earlier this month, and just one day after Leung’s successor was elected in a controversial election, police announced they would charge nine people involved in the 2014 democracy protests.
(20) De Boer's successor's first tasks will be to keep the US aboard the negotiations and to clear up the vexed question of the legal status of the Copenhagen accord , the deal struck at Copenhagen by a small group but not endorsed by a majority of countries.