(n.) The act of substituting or putting one person or thing in the place of another; as, the substitution of an agent, attorney, or representative to act for one in his absense; the substitution of bank notes for gold and silver as a circulating medium.
(n.) The state of being substituted for another.
(n.) The office or authority of one acting for another; delegated authority.
(n.) The designation of a person in a will to take a devise or legacy, either on failure of a former devisee or legatee by incapacity or unwillingness to accept, or after him.
(n.) The doctrine that Christ suffered vicariously, being substituted for the sinner, and that his sufferings were expiatory.
(n.) The act or process of substituting an atom or radical for another atom or radical; metethesis; also, the state of being so substituted. See Metathesis.
Example Sentences:
(1) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(2) In the clinical trials in which there was complete substitution of fat-modified ruminant foods for conventional ruminant products the fall in serum cholesterol was approximately 10%.
(3) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(4) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(5) The resonance Raman spectra of oxy and deoxy cobalt-substituted hemoglobin (CoHb) are reported.
(6) The most important conclusion of both conferences was that oestrogen substitution can significantly reduce the incidence of fractures in postmenopausal women.
(7) S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine.
(8) This implies that the epitope(s) of NNA-PLA2 might comprise some substituted residues in the sequence of PLA2 homologues.
(9) The deletions and substitutions appear to occur in separate molecules.
(10) Combination of domain substitutions to generate the [Glu107,123]bFGF and [Arg19,Lys123,126]bFGF mutants did not show any additivity of the mutations on biological activity.
(11) N-Methoxysulphonamides showed no inhibitory activity, as predicted by the classic work of Krebs on N-substituted inhibitors.
(12) Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N-methyl-D-glucamine HCl.
(13) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(14) Substitutes: Andoni Zubizarreta (Spain), Lajos Detari (Hungary), Dragan Stojkovic (Yugoslavia), Igor Belanov (USSR), Preben Elkjær Larsen (Denmark), Lars Larsson (Sweden), Alexandre Zavarov (USSR).
(15) Lipoprotein concentrations reverted to normal after substitution with thyroxine (T4) until the euthyroid state was reached.
(16) Taken together with our previous studies showing that MDMA substitutes for the phenylisopropylamine stimulant (+)amphetamine, but that neither MDE nor N-OH MDA substitute for (+)amphetamine or for the phenylisopropylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), the present results [i.e., MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine] suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N-OH MDA are MDMA-like agents with even less of an amphetamine-like component of action than MDMA itself.
(17) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
(18) Substitution of DnaK protein with that of the mutant DnaK756 protein blocks lambda P release.
(19) To selectively stain polyanionic macromolecules of growth plate cartilage and to prevent artifacts induced by aqueous fixation, proximal tibial growth plates were excised from rats, slam-frozen, and freeze-substituted in 100% methanol containing the cationic dye Alcian blue.
(20) Plasma drug concentrations, subjective self-ratings, and the digit symbol substitution test (DSST) were evaluated during 24 hours after dosage.
Tertiary
Definition:
(a.) Being of the third formation, order, or rank; third; as, a tertiary use of a word.
(a.) Possessing some quality in the third degree; having been subjected to the substitution of three atoms or radicals; as, a tertiary alcohol, amine, or salt. Cf. Primary, and Secondary.
(a.) Later than, or subsequent to, the Secondary.
(a.) Growing on the innermost joint of a bird's wing; tertial; -- said of quills.
(n.) A member of the Third Order in any monastic system; as, the Franciscan tertiaries; the Dominican tertiaries; the Carmelite tertiaries. See Third Order, under Third.
(n.) The Tertiary era, period, or formation.
(n.) One of the quill feathers which are borne upon the basal joint of the wing of a bird. See Illust. of Bird.
Example Sentences:
(1) The purpose of this study was to define risk factors for nosocomial candidemia in adult patients without leukemia at a tertiary care medical center.
(2) injection of the tertiary amine cholinesterase inhibitor physostigmine (17-70 micrograms kg-1) induced a prompt, sustained and dose-dependent improvement of cardiovascular and respiratory function, with marked increase in the volume of circulating blood and survival of all treated animals, at least for the 2 h of observation.
(3) The measurement procedure should define preanalytical requirements and be based upon traceability from tertiary and secondary reference materials with reference procedure values to primary reference materials.
(4) The expression of such secondary and tertiary syphilis is commonly masked and distorted by the long-term effects of subcurative doses of antibiotics; in fact, late latent and tertiary syphilis produce symptoms and immunosuppression similar to the profile of AIDS.
(5) It is suggested that lung ventilation takes place in the avian embryo in three distinct stages: the major air-ways become aerated, then respiratory movements begin and lastly the tertiary bronchi are slowly aerated.
(6) The disappearance of this band on heating and at high pH was ascribed to the adoption by the telopeptide of a specific tertiary structure.
(7) To demonstrate the feasibility of the approach tRNA was represented as a simple undirected graph containing all relevant information represented in the usual cloverleaf secondary structure and nine base-base tertiary interactions.
(8) The use of Fab fragments in conjunction with Fab-specific secondary and tertiary antisera improved tissue penetration and made it possible to identify a number of the immunoreactive neurons.
(9) At the 200 rad level, the mouse with normal karyotype was compared with the T(1;13)70H translocation heterozygote and the Ts(1(13))7OH tertiary trisomic of normal appearance.
(10) Transmembrane proteins serve important biological functions, yet precise information on their secondary and tertiary structure is very limited.
(11) The participants were divided into seven groups in accordance with their main lines of work: professors, administrative personnel, doctors at the primary, secondary and tertiary care level, residents, and medical students.
(12) With the growing number of dialyzed patients, secondary (sHPT) and tertiary hyperparathyroidism (tHPT) are assuming increasing importance.
(13) Establishing direct lines of communication between the practicing physician and the tertiary center and emphasizing continuing education at all levels seem to be important aspects in the development and maintenance of such a referral system.
(14) A similar transient decrease in 80K mRNA levels was also demonstrated in tertiary cultures of mouse embryo fibroblasts.
(15) These results suggest that the secondary structure of interleukin-2(Ala125) does not require tertiary structure.
(16) The absence of chemical reactivities and cobra venom nuclease sensitivity in the terminal loops of helices 6 and 12 indicate a tertiary interaction unique to HeLa 18S rRNA.
(17) Ultraviolet photocrosslinks seen only in the 30 S particle are likely to be tertiary structure contacts.
(18) As the tertiary test, inhibitors with molecular weights under 1,000 were selected by passage through a Diaflo UM-2 membrane.
(19) The pediatrician is instrumental in identifying potential candidates for epilepsy surgery and referring them to a tertiary-care epilepsy center.
(20) Performance of renal transplants in children frequently necessitates transfer of patients from the care of a local pediatric nephrologist to a regional, tertiary care center that is specially equipped to carry out organ transplantation.