(n.) The act of substituting or putting one person or thing in the place of another; as, the substitution of an agent, attorney, or representative to act for one in his absense; the substitution of bank notes for gold and silver as a circulating medium.
(n.) The state of being substituted for another.
(n.) The office or authority of one acting for another; delegated authority.
(n.) The designation of a person in a will to take a devise or legacy, either on failure of a former devisee or legatee by incapacity or unwillingness to accept, or after him.
(n.) The doctrine that Christ suffered vicariously, being substituted for the sinner, and that his sufferings were expiatory.
(n.) The act or process of substituting an atom or radical for another atom or radical; metethesis; also, the state of being so substituted. See Metathesis.
Example Sentences:
(1) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(2) In the clinical trials in which there was complete substitution of fat-modified ruminant foods for conventional ruminant products the fall in serum cholesterol was approximately 10%.
(3) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(4) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(5) The resonance Raman spectra of oxy and deoxy cobalt-substituted hemoglobin (CoHb) are reported.
(6) The most important conclusion of both conferences was that oestrogen substitution can significantly reduce the incidence of fractures in postmenopausal women.
(7) S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine.
(8) This implies that the epitope(s) of NNA-PLA2 might comprise some substituted residues in the sequence of PLA2 homologues.
(9) The deletions and substitutions appear to occur in separate molecules.
(10) Combination of domain substitutions to generate the [Glu107,123]bFGF and [Arg19,Lys123,126]bFGF mutants did not show any additivity of the mutations on biological activity.
(11) N-Methoxysulphonamides showed no inhibitory activity, as predicted by the classic work of Krebs on N-substituted inhibitors.
(12) Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N-methyl-D-glucamine HCl.
(13) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(14) Substitutes: Andoni Zubizarreta (Spain), Lajos Detari (Hungary), Dragan Stojkovic (Yugoslavia), Igor Belanov (USSR), Preben Elkjær Larsen (Denmark), Lars Larsson (Sweden), Alexandre Zavarov (USSR).
(15) Lipoprotein concentrations reverted to normal after substitution with thyroxine (T4) until the euthyroid state was reached.
(16) Taken together with our previous studies showing that MDMA substitutes for the phenylisopropylamine stimulant (+)amphetamine, but that neither MDE nor N-OH MDA substitute for (+)amphetamine or for the phenylisopropylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), the present results [i.e., MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine] suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N-OH MDA are MDMA-like agents with even less of an amphetamine-like component of action than MDMA itself.
(17) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
(18) Substitution of DnaK protein with that of the mutant DnaK756 protein blocks lambda P release.
(19) To selectively stain polyanionic macromolecules of growth plate cartilage and to prevent artifacts induced by aqueous fixation, proximal tibial growth plates were excised from rats, slam-frozen, and freeze-substituted in 100% methanol containing the cationic dye Alcian blue.
(20) Plasma drug concentrations, subjective self-ratings, and the digit symbol substitution test (DSST) were evaluated during 24 hours after dosage.
Translocation
Definition:
(n.) removal of things from one place to another; substitution of one thing for another.
Example Sentences:
(1) It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by nuclear translocation.
(2) The original X or the Y, respectively, have been translocated on to an autosome.
(3) Inhibition of fast axonal transport by an antibody specific for kinesin provides direct evidence that kinesin is involved in the translocation of membrane-bounded organelles in axons.
(4) All treatments cause equal translocation of receptor of the nuclear compartment.
(5) A reciprocal translocation, identified as t(6p+; 14q-), is described in a 38,XX intersex pig.
(6) Comparison of germline and translocation clones demonstrated that breakage of chromosome 1 had occurred at the border of a tandem repeat of Alu sequences.
(7) The translocation t(4;11)(q21;q23) is considered a chromosomal marker of acute lymphoid leukemia.
(8) Reciprocal translocations involving the short arm of acrocentric chromosomes can segregate to produce partial duplications without associated deletions.
(9) The risk of the chromosomal translocation should be increased by increasing the number of new B cells generated per time.
(10) Cellular energy production was found to be essential for intracellular translocation of phospholipids, but neither a membrane potential nor an intact cytoskeleton are required for this process.
(11) The translocation of nascent PtdSer to the mitochondria was unaffected by 45-fold dilution of the standard reaction thus indicating that the translocation intermediate was unlikely to be a freely diffusible complex.
(12) The protein was abundant in all t(14;18)-carrying cell lines and lymphomas and was also found at lower levels in pre-B-cell lines and nonmalignant lymphoid tissues that do not carry t(14;18) translocations.
(13) The biochemical properties of the following proteins are considered: i) kinesin, the protein translocating particles to the distal end of microtubules and, ii) dynein which promotes translocation in the opposite direction.
(14) PMA and bryostatin-1 translocated protein kinase-C activity from the soluble to particulate fractions of cell homogenates.
(15) Translocation occurred after behavioral training of the animal and after application to isolated ganglia of serotonin or phorbol esters.
(16) This correlation suggests that dominant lethal mutations in embryos and translocations in germ cells both result from similar radiation-induced chromosome damage.
(17) In the progeny of the surviving males, neither translocations nor independent fragments are found; indirect evidence indicated the occasional presence of inversions.
(18) In a direct test of the hypothesis that the M2 coat protein of influenza A can function as a proton translocator, we incorporated a synthetic peptide containing its putative transmembrane domain into voltage-clamped planar lipid bilayers.
(19) This study also demonstrates that pulsed-field gel electrophoresis is a powerful new tool for the analysis of human chromosomal translocations.
(20) It is concluded that the insulinotropic action of cAMP could be due to a glucose-independent translocation of calcium within the beta cell, from an organelle-bound pool to a cytoplasmic pool of ionized calcium readily available for transport across the cell membrane.