(1) The results indicate that OA-bearing macrophages primed T cells and generated helper T cells, whereas the culture of normal lymphocytes with soluble OA in the absence of macrophages generated suppressor T cells.
(2) Cop rats, however, possess a single 'suppressor' gene which confers complete resistance to mammary cancer.
(3) Pedigree studies have suggested that there may be an inherited predisposition to many apparently nonfamilial colorectal cancers and a genetic model of tumorigenesis in common colorectal cancer has been proposed that includes the activation of dominantly acting oncogenes and the inactivation of growth suppressor genes.
(4) The NM23-Hl gene is a putative tumor suppressor gene that may be important in the metastasic process.
(5) Tumorigenesis is a multistep process involving mutations of dominantly acting proto-oncogenes and mutations and loss-of-function mutations of tumor suppressor genes.
(6) To assess the role of amniotic fluid (AMF) in the maintenance of pregnancy, immunosuppressive effects of AMF were studied in vivo, and the mechanisms of suppressor activity were analyzed immunologically in vitro in the rat.
(7) Allelic complementation was not observed, despite testing of a large number of allele pairs, and alleles suppressible by the ochre suppressor SUP11 were absent from a sample of 48 spontaneous mutants and occurred infrequently (7%) among a sample of ultraviolet-induced mutants.
(8) To this end, a meiosis-defective mating-type mutation was used as a marker for the plus segment, by taking advantage of its suppressibility by a nonsense suppressor.
(9) Conversely, rat galanin increased unstimulated glucagon output (approximately 20%, P less than 0.05), potentiated the glucagon response to arginine (approximately 50%, P less than 0.05) and VIP (approximately 90%, P less than 0.05), and counteracted the suppressor effect of glucose on alpha-cell secretion.
(10) Newborn suppressor T cells were characterized as being non-adherent to Ig-anti-Ig affinity columns, soybean agglutinin receptor negative (SBA-), and susceptible to lysis by anti-T-cell specific antiserum plus complement.
(11) The spontaneous v alleles that are suppressed by the suppressor of sable [su(s)] are apparently identical insertions of 412, a copia-like transposable element.
(12) Transforming activity is closely linked with the presence of a region designated conserved domain 2 and the ability of this region to bind the product of the cellular retinoblastoma tumor suppressor gene.
(13) In addition, we have shown that long-lived, presumably non-senescent, strains do not arise by suppressor mutation, but lose senescence plasmid DNA by another mechanism.
(14) Because haptenated cells can induce immunity if injected subcutaneously or into cyclophosphamide-pretreated recipients (thereby avoiding the induction of suppressor cells), we suggest that the activation of contrasuppressor cells by antigen-antibody complexes overrides suppressive influences in the host, allowing immunity to become dominant.
(15) This strain does not suppress phage phi 29 mutant susB47, selected on a B. subtilis strain containing the su+3 suppressor isolated by Georgopoulos.
(16) The suppressor cell is radioresistant; requires 24 hr to suppress optimally; is inactivated by heating at 56 degrees C for 15 min, and is enriched in the non-T interface after SRBC rosette depletion over a discontinuous Ficoll-Hypaque gradient.
(17) The decline in DTH response was found to be associated with suppressor cells generated by intraperitoneal immunization and could be prevented by cyclophosphamide treatment prior to immunization.
(18) To test for the presence of suppressor cells in peripheral blood, we have modified the standard, one-way mixed lymphocyte culture by adding mitomycin C-treated mononuclear cells from the responder.
(19) A yeast protein, Sui3, isolated as an extragenic suppressor of his4 initiation codon mutations, exhibits extensive sequence identity with human eIF-2 beta, especially in the polylysine and zinc finger domains, thereby reinforcing the view that these elements are important for function.
(20) These regions seem to be important in the activity of gpE, since amber mutations in these regions are suppressed on the average by less species of suppressors than those outside these regions.
Tyrant
Definition:
(n.) An absolute ruler; a sovereign unrestrained by law or constitution; a usurper of sovereignty.
(n.) Specifically, a monarch, or other ruler or master, who uses power to oppress his subjects; a person who exercises unlawful authority, or lawful authority in an unlawful manner; one who by taxation, injustice, or cruel punishment, or the demand of unreasonable services, imposes burdens and hardships on those under his control, which law and humanity do not authorize, or which the purposes of government do not require; a cruel master; an oppressor.
(n.) Any one of numerous species of American clamatorial birds belonging to the family Tyrannidae; -- called also tyrant bird.
(v. i.) To act like a tyrant; to play the tyrant; to tyrannical.
Example Sentences:
(1) The fall of a tyrant is usually the cause of popular rejoicing followed by public vengeance.
(2) While the Spielberg of popular myth is Mr Nice Guy, Lean was known as an obsessive, cantankerous tyrant who didn't much like actors and was only truly happy locked away in the editing suite.
(3) "Sometimes a handshake is just a handshake, but when the leader of the free world shakes the bloody hand of a ruthless dictator like Raúl Castro , it becomes a propaganda coup for the tyrant," said Ileana Ros-Lehtinen, the Republican Congress member in Florida, told the US secretary of state, John Kerry.
(4) One of the two last strongholds of Gaddafi loyalists, the town of Bani Walid, has finally been contained, Libya's interim government has claimed, leaving only parts of the ousted tyrant's birthplace out of rebel reach.
(5) So long as tyrants and terrorists chase innocents around the globe, we must offer them refuge.
(6) Thinking the fatwa was little more than the empty threat of a faraway tyrant, Theroux called out to Rushdie: "Next week we'll be back here for you!"
(7) The phrase "time to water the tree of liberty" - a reference to a famous quotation from Thomas Jefferson, "The tree of liberty must be refreshed from time to time with the blood of patriots and tyrants" - is also frequently used by a right wing group called Stormfront , motto White Pride World Wide.
(8) Its words are an attack on tyrants and despots, and a call for liberty.
(9) He is a tyrant and he needs to be expelled from the newspaper."
(10) Other tyrants, including, Muammar Gaddafi and Saddam Hussein, appeared equally unconcerned about the ICC.
(11) Fearful of an imminent military breakthrough by Iran, the agency passed on Iranian troop positions to the Iraqi tyrant, " fully aware that Hussein's military would attack with chemical weapons, including sarin ".
(12) "The Tyrant's In His Pants," said the Sun's headline, while the Post opted for "Butcher of Sagdad" against an image of Hussein wearing nothing more than a pair of white Y-fronts.
(13) A toy autocracy may easily invite a real one; it was recently revealed that nuclear war would have made the monarch a genuine tyrant with the power to appoint a prime minister without an election, although it is hard to imagine Elizabeth II – with her rugs bearing a knitted royal crest, and her tiny dogs – as Gaius Julius Caesar.
(14) On the face of it, algorithms – "step-by-step procedures for calculations" – seem unlikely candidates for the role of tyrant.
(15) He might, according to people who know him, be a nerdy academic, but he was also a tyrant, according to Blanchflower , a “my way or the highway” boss who ran the place with an iron fist.
(16) If we’re supposed to become nails in the coffin of a tyrant, I’d like to become one of those nails.
(17) Devout Muslims consider it a sacrilege for infidels to depose a Muslim tyrant and occupy Muslim lands — no matter how well intentioned the infidels or malevolent the tyrant.
(18) Mobutu Nzanga said he is proud of his father, despite the commonly held view that he was a kleptocratic tyrant.
(19) The letter says : “As rabbis and cantors we regularly read the story of a band of refugees who escaped from a tyrant with only the clothes on their backs and a bit of flat bread.
(20) In a video posted on social media on Sunday, a man purporting to be Shekau addresses the “tyrants of Nigeria in particular and the west of Africa in general,” saying: “You broadcast the news and published it in your media outlets that you injured me and killed me, and here I am.” The speaker says: “I will not be killed until my time comes.” Last month, Nigeria’s air force said it had killed senior members of Boko Haram and that Shekau had been injured .