(1) The two structures are mirror images and the central C--C--N--C--C chain adopts the anti-periplanar-synclinal conformation.
(2) In both monomeric and aggregated states the phosphocholine function of 1 adopts the synclinal conformation (alpha 5 torsional angle), in analogy with phosphatidylcholine (Hauser, H., Guyer, W., Pascher, I., Skrabal, P. and Sundell, S. (1980) Biochemistry 19, 366-373).
(3) The requirements of compounds in the cyclamate series for sweet taste stimulation are: synclinal conformation between NH and SO in the aminosulphonate group, length less than 0.7 nm of the group on the nitrogen, and hydrophobic character of the latter group.
(4) The alpha-methyl group is fully extended (antiplanar) whereas the amino group is orientated back towards the ring (synclinal).
(5) The compound is a potential antiarrhythmic and the molecule has the typical synclinal conformation for the -NH-CH-CH2-OH fragment of the side chain [tau CC = 56.5 (8) degrees] exhibited by these compounds.
(6) A comparison with the native crystal structure, where SO-4(2) is bound, revealed five changes: (a) a 0.10-nm shift of the anion-binding site; (b) a further closing of the flexible loop of the enzyme; (c) a 'swinging in' of the side chain of the catalytic Glu, that is chi 1 changes from (+) to (-) synclinal; (d) an altered water structure; (e) a disappearance of the conformational heterogeneity at the C-terminus of strand beta 7.
(7) One of these (rotamer A) is characterized by torsion angles theta 3 = antiperiplanar, theta 4 = +synclinal, and the other (rotamer B) by theta 3 = +synclinal, theta 4 = -synclinal.
(8) In both rotamers A and B the ester oxygens on the glycerol carbon atoms C(2) and C(3) are synclinal, and hence both types of rotamers readily allow the parallel alignment of the two hydrocarbon chains.
(9) The two fatty acid substituted glycerol oxygens have mutually a - synclinal rather than the more common + synclinal conformation.
(10) The X-ray crystal structure conformation for compound 22 (2-[2-(1H-indol-3-yl)ethyl]-3-]-3-(1-methylethoxy) phenyl]-4(3H)-quinazolinone, IC50 = 0.026 microM) is extended with the two heteroaromatic rings adopting an antiperiplanar arrangement around the central sigma bond of the ethane linker, whereas the solid-state conformation for a less active analogue 19 (2-[2-(1H-indol-3-yl)-1-methylethyl]-3-[3-(1- methylethoxy)phenyl]-4(3H)-quinazolinone, IC50 = 9.1 microM) is folded with the two heteroaromatic systems adopting a synclinal orientation.
(11) Whereas both solid-state (+-)-orphenadrine hydrochloride and diphenhydramine hydrochloride [(CH3)2NCH2CH2OCH(Ph)2.HCl] have synclinal N-C-C-O and antiperiplanar NC-C-O-CAr2 torsion angles, the former has a helical arrangement for Ar2CH, as expected, and the phenyl rings in the latter are disposed in a nonhelical, "open-book" arrangement.
(12) The conformation about the C1-C2 bond (theta 1 angle) of the sphingosine backbone is predominantly -synclinal, analogously to the conformation of the crystalline galactosyl cerebroside (Pascher, I. and Sundell, S. (1977) Chem.
Upward
Definition:
(adv.) Alt. of Upwards
(a.) Directed toward a higher place; as, with upward eye; with upward course.
(n.) The upper part; the top.
Example Sentences:
(1) However, a highly significant upward shift of the proliferating cell compartment was observed in the cancer group, resulting in a specific modification of the [3H]TDR labeling pattern in 6 of 17 specimens.
(2) Moments later, Strauss introduces the bold human character with an energetic, upwards melody which he titles "the climb" in the score.
(3) They also questioned why George Osborne and the Treasury failed to realise there was a potential issue earlier in the calculation process – pointing to recent upwards revisions of post-1995 gross national income by the UK’s own statistics watchdog.
(4) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(5) The authors decided to keep in this series only hips presenting with a very considerable upward displacement of the femoral head of type IV in Crowe, Maini and Ranawat's classification.
(6) In this study downward gaze was more severely disturbed than upward gaze.
(7) on, whereas palpation is only possible upward of 15 mm.
(8) Past measurements have shown that the intensity range is reduced at the extremes of the F0 range, that there is a gradual upward tilt of the high- and low-intensity boundaries with increasing F0, and that a ripple exists at the boundaries.
(9) We have the nuclear-related wealth, which captures the highly skilled and the affluent and the upwardly mobile.
(10) In the absence of glutamine the aggregate is readily dissociated following dilution of the extract; that is, velocity concaves upward as a function of increasing protein concentration.
(11) This contralateral defect involved the foot and extended upwards to end in a sensory level.
(12) Isolated frog retinas kept receptor side-upward in a moist chamber without perfusion showed the well-known slow PIII generated by the potassium decrease around receptors.
(13) Levels of alpha 1-antitrypsin (A 1-AT) showed marked season-related fluctuation patterns in Co children, the curves in E group children turned steeply upward from the third examination series on.
(14) The first eigenvector, when represented by grey scale maps depicting a pair of eyes, reveals that, as average threshold increases, the visual field rises and flattens, like an umbrella that, initially closed, is simultaneously opened and thrust upwards.
(15) UMLBs (n = 14) had no spontaneous activity and emitted bursts of action potentials that preceded rapid eye movements by approximately 6 ms. Parameters of the burst (duration and number of spikes) were highly correlated with parameters of the rapid eye movement (duration and amplitude of the upward displacement of the eyes).
(16) Put simply, there would have to be evidence that ultra-low oil prices are having only a temporary downward impact on inflation and have helped disguise upward pressure on wages caused by falling unemployment.
(17) With systole there is downward (caudal) flow of CSF in the aqueduct of Sylvius, the foramen of Magendie, the basal cisterns and the dorsal and ventral subarachnoid spaces while during diastole, upward (cranial) flow of CSF in these same structures is seen.
(18) During the operation an upward looping PICA was found crossing and tightly compressing the exit zone of the right facial nerve.
(19) After upward transposition of the anterior lamella, the excised skin is very suitable for covering the free tarsal surface.
(20) Assuming no future environmental or lifestyle changes, the upward trend in age-adjusted mortality rates, which averaged 2 to 3% per annum since 1950, is projected to discontinue and bend downward by the second decade of the 21st century.